{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T08:23:49Z","timestamp":1773044629356,"version":"3.50.1"},"reference-count":0,"publisher":"Sociedad Chilena de Pediatria","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Chil Pediatr"],"abstract":"<jats:p>El Sangrado Menstrual Excesivo (SME) es un problema frecuente en la adolescencia. La prevalencia de trastornos hereditarios de la coagulaci\u00f3n (THC) como causa del SME no est\u00e1 bien establecida y la participaci\u00f3n de defectos de la v\u00eda fibrinol\u00edtica\u00a0\u00a0 ha sido poco explorada.Objetivo: determinar la prevalencia de THC y defectos de la fibrin\u00f3lisis en adolescentes con SME.Pacientes y M\u00e9todo: Se incluyeron 93 adolescentes, edad 11 a 18 a\u00f1os. Los antecedentes personales y familiares de sangrado se obtuvieron con un cuestionario estandarizado. Se control\u00f3 ex\u00e1menes: tiempo de protrombina (TP), tiempo de tromboplastina parcial activada (TTPa), estudio del factor Von Willebrand, recuento y funci\u00f3n plaquetaria. Los pacientes que no fueron diagnosticados como THC, se evaluaron adicionalmente con el tiempo de lisis del co\u00e1gulo.Resultados: 41 pacientes (44%) fueron diagnosticados como THC: Enfermedad de Von Willebrand n=28, defectos de la funci\u00f3n plaquetaria n=8, hemofilia leve n=5. Se confirm\u00f3 disminuci\u00f3n del tiempo de lisis del co\u00e1gulo en 31 pacientes. El 54% de pacientes diagnosticado como THC,\u00a0 tuvo SME como la primera manifestaci\u00f3n hemorr\u00e1gica.\u00a0Conclusi\u00f3n: Estos resultados apoyan la necesidad de evaluaci\u00f3n de la coagulaci\u00f3n, incluyendo la v\u00eda fibrinol\u00edtica, en el estudio de adolescentes con SME.<\/jats:p>","DOI":"10.32641\/rchped.v91i3.1571","type":"journal-article","created":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T14:44:42Z","timestamp":1592577882000},"page":"385","source":"Crossref","is-referenced-by-count":3,"title":["Trastornos hereditarios de la coagulaci\u00f3n en adolescentes con sangrado menstrual excesivo, \u00bfDebemos evaluar la v\u00eda fibrinol\u00edtica?"],"prefix":"10.32641","volume":"91","author":[{"given":"Aguirre","family":"N.","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pereira","family":"J.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barriga","family":"F.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wietstruck","family":"MA.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panes","family":"O.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sepulveda","family":"P.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salgado","family":"A.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zu\u00f1iga","family":"P.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"17639","published-online":{"date-parts":[[2020,6,19]]},"container-title":["Revista Chilena de Pediatr\u00eda"],"original-title":[],"link":[{"URL":"http:\/\/www.revistachilenadepediatria.cl\/index.php\/rchped\/article\/viewFile\/1571\/2213","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.revistachilenadepediatria.cl\/index.php\/rchped\/article\/viewFile\/1571\/2213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T18:28:32Z","timestamp":1618252112000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.revistachilenadepediatria.cl\/index.php\/rchped\/article\/view\/1571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,19]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,6,19]]}},"URL":"https:\/\/doi.org\/10.32641\/rchped.v91i3.1571","relation":{},"ISSN":["0370-4106","0370-4106"],"issn-type":[{"value":"0370-4106","type":"electronic"},{"value":"0370-4106","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6,19]]}}}