{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:06:03Z","timestamp":1787025963713,"version":"build-2736575974"},"reference-count":0,"publisher":"Sociedad Chilena de Pediatria","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Chil Pediatr"],"abstract":"<jats:p>Introducci\u00f3n: El s\u00edndrome de Marf\u00e1n es un trastorno multisist\u00e9mico del tejido conectivo de herencia autos\u00f3mica dominante, de expresi\u00f3n variable. La ectasia dural es un compromiso frecuente, pero poco conocido, que puede asociarse a s\u00edndrome de hipotensi\u00f3n endocraneana (SHE).Objetivo: Presentar un caso de cefalea invalidante secundario a SHE, para advertir de esta rara complicaci\u00f3n, que debe tenerse presente en ni\u00f1os portadores de conectivopat\u00edas, en especial s\u00edndrome de Marf\u00e1n.Caso Cl\u00ednico: Adolescente femenina de 13 a\u00f1os, portadora de sindrome de Marf\u00e1n, de diagn\u00f3stico cl\u00ednico seg\u00fan criterios de Ghent 2010, que consult\u00f3 por cefalea ortostatica invalidante de 6 meses de evoluci\u00f3n. La Resonancia Magnetica (RM) de cerebro mostr\u00f3 m\u00faltiples signos de hipotensi\u00f3n endocraneana, mientras que la RM de columna total mostr\u00f3 una ectasia dural que determin\u00f3 la dilataci\u00f3n del saco tecal y remodelaci\u00f3n posterior de los cuerpos vertebrales, especialmente a nivel del sacro. Se realiz\u00f3 tratamiento con parche sangu\u00edneo aut\u00f3logo epidural con buena respuesta cl\u00ednica.Conclusiones: La ectasia dural, frecuente en el sindrome de Marf\u00e1n, es una causa predisponente a fuga de l\u00edquido cefaloraquideo (LCR), que podr\u00eda causar cefalea ortost\u00e1tica segundaria al SHE.<\/jats:p>","DOI":"10.32641\/rchped.v91i4.1233","type":"journal-article","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T18:45:18Z","timestamp":1597430718000},"source":"Crossref","is-referenced-by-count":9,"title":["Ectasia dural e hipotensi\u00f3n endocraneal en s\u00edndrome de Marf\u00e1n"],"prefix":"10.32641","volume":"91","author":[{"given":"Andrea","family":"Pichott","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Bernstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Guzm\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Fari\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Aguirre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An\u00edbal","family":"Espinoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"17639","published-online":{"date-parts":[[2020,8,14]]},"container-title":["Revista Chilena de Pediatr\u00eda"],"original-title":[],"link":[{"URL":"http:\/\/revistachilenadepediatria.cl\/index.php\/rchped\/article\/viewFile\/1233\/2323","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/revistachilenadepediatria.cl\/index.php\/rchped\/article\/viewFile\/1233\/2323","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T14:28:38Z","timestamp":1618237718000},"score":1,"resource":{"primary":{"URL":"http:\/\/revistachilenadepediatria.cl\/index.php\/rchped\/article\/view\/1233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,14]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,8,14]]}},"URL":"https:\/\/doi.org\/10.32641\/rchped.v91i4.1233","relation":{},"ISSN":["0370-4106","0370-4106"],"issn-type":[{"value":"0370-4106","type":"electronic"},{"value":"0370-4106","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8,14]]}}}