{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:46:42Z","timestamp":1753890402590,"version":"3.41.2"},"reference-count":36,"publisher":"Revista Cientifica Multidisciplinar Nucleo Do Conhecimento","license":[{"start":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:00:00Z","timestamp":1698710400000},"content-version":"vor","delay-in-days":84,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.pt_BR"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Revista Cient\u00edfica Multidisciplinar N\u00facleo do Conhecimento"],"abstract":"<jats:p>Die hohe Affinit\u00e4t zwischen dem Spike-Protein des SARS-CoV-2-Virus und dem Rezeptor f\u00fcr die Angiotensin-Converting-Enzym 2 wird als einer der Hauptgr\u00fcnde f\u00fcr die hohe \u00dcbertragungsrate des Virus angesehen. Dies f\u00fchrte dazu, dass die WHO COVID-19 als eine gesundheitliche Notlage von internationaler Tragweite erkl\u00e4rte und Ma\u00dfnahmen zur Eind\u00e4mmung der Virusausbreitung ergriff. Dar\u00fcber hinaus werden aufgrund des pathophysiologischen Mechanismus des Virus im Allgemeinen unspezifische Symptome, atypischer Verlauf, insbesondere bei \u00e4lteren Menschen und immungeschw\u00e4chten Personen, sowie ein schnellerer und t\u00f6dlicherer Verlauf beobachtet. Ebenso wurden im Laufe des Wissensfortschritts \u00fcber den nat\u00fcrlichen Verlauf der Virusinfektion anhaltende Symptome und\/oder Folgen festgestellt, die Organfunktionsst\u00f6rungen verursachen und die Lebensqualit\u00e4t der Patienten negativ beeinflussen. Angesichts dessen lautete das Ziel des Artikels, eine integrative \u00dcbersicht \u00fcber die wichtigsten Folgen von COVID-19 in den Jahren 2021 und 2022 zu geben. Zu diesem Zweck wurden Volltextartikel in den Forschungsdatenbanken Scientific Electronic Library Online, Biblioteca Virtual em Sa\u00fade und PubMed in den Sprachen Portugiesisch und Englisch gesucht und die PRISMA-Methodik (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) angewendet, wobei 14 Artikel ausgew\u00e4hlt wurden. Zu den Ergebnissen geh\u00f6ren: Die Pathogenese von anhaltendem COVID-19 basiert auf der Theorie von Immunph\u00e4nomenen, die auf die Infektion folgen, einer abnormen Immunantwort und dem Vorhandensein des Virus an immunologisch privilegierten Stellen; Fatigue, Atemnot, subjektive kognitive Beeintr\u00e4chtigung, neurologische Folgen, entz\u00fcndliche Erkrankungen des zentralen Nervensystems und postvirale Riechst\u00f6rungen sind h\u00e4ufige Komplikationen; Es wurden Hinweise auf einen kausalen Zusammenhang zwischen COVID-19 und subakuter Schilddr\u00fcsenentz\u00fcndung pr\u00e4sentiert; Es wurde eine h\u00f6here Anzahl von Komplikationen und Krankenhausaufenthalten bei Patienten mit Vitamin-D-Mangel nachgewiesen; sowie das Vorhandensein neuropsychiatrischer Symptome in der Bev\u00f6lkerung von Gesundheitsfachkr\u00e4ften. Zusammenfassend wurde ein Mangel an Arbeiten zu den Folgen von COVID-19 festgestellt, was eine Vertiefung dieser Forschungen erforderlich macht, um spezifischere Diagnoseprotokolle zu erstellen.<\/jats:p>","DOI":"10.32749\/nucleodoconhecimento.com.br\/gesundheit\/langzeitfolgen-von-covid-19","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T18:52:23Z","timestamp":1698778343000},"page":"68-87","update-policy":"https:\/\/doi.org\/10.13003\/0pyd3js","source":"Crossref","is-referenced-by-count":0,"title":["Langzeitfolgen von COVID-19: Eine integrative Literatur\u00fcbersicht"],"prefix":"10.32749","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3070-4823","authenticated-orcid":false,"given":"Luiz Thiago Oliveira","family":"Lopes","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9251-1263","authenticated-orcid":false,"given":"Marcelus de Andrade","family":"Oliveira","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2383-7695","authenticated-orcid":false,"given":"Willian Guilherme Lobato","family":"Gon\u00e7alves","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6249-0808","authenticated-orcid":false,"given":"Donizete Vago","family":"Daher","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8825-4923","authenticated-orcid":false,"given":"Irma da Silva","family":"Brito","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2952-4337","authenticated-orcid":false,"given":"Carla Viana","family":"Dendasck","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0840-6307","authenticated-orcid":false,"given":"Cl\u00e1udio Alberto Gellis de Mattos","family":"Dias","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5128-8903","authenticated-orcid":false,"given":"Amanda Alves","family":"Fecury","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7742-144X","authenticated-orcid":false,"given":"Maria Helena Mendon\u00e7a de","family":"Ara\u00fajo","sequence":"additional","affiliation":[]}],"member":"18045","published-online":{"date-parts":[[2023,8,8]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"AFAGHI, Siamak et al. 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