{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:43:06Z","timestamp":1753890186791,"version":"3.41.2"},"reference-count":36,"publisher":"Revista Cientifica Multidisciplinar Nucleo Do Conhecimento","license":[{"start":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:00:00Z","timestamp":1698710400000},"content-version":"vor","delay-in-days":84,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.pt_BR"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Revista Cient\u00edfica Multidisciplinar N\u00facleo do Conhecimento"],"abstract":"<jats:p>L\u2019alta affinit\u00e0 tra la proteina Spike del virus SARS-CoV-2 e il recettore dell\u2019enzima di conversione dell\u2019angiotensina 2 \u00e8 postulata come una delle principali ragioni per l\u2019alta taxa di trasmissione virale, che ha portato l\u2019OMS a dichiarare la COVID-19 come Emergenza Sanitaria Pubblica di Interesse Internazionale, nonch\u00e9 ad adottare misure di contenimento della diffusione virale. Inoltre, grazie al meccanismo fisiopatologico del virus, si osservano sintomi non specifici, evoluzione atipica, soprattutto negli anziani e nei pazienti immunodepressi, nonch\u00e9 una progressione pi\u00f9 rapida e letale. Allo stesso modo, con l\u2019avanzare della conoscenza sulla storia naturale dell\u2019infezione virale, sono state riscontrate sintomi persistenti e\/o conseguenze che causano disfunzioni organiche e impattano negativamente sulla qualit\u00e0 della vita dei pazienti. Di fronte a ci\u00f2, lo scopo dell\u2019articolo \u00e8 stato presentare una revisione integrativa sulle principali conseguenze della COVID-19 negli anni 2021 e 2022. A tal fine, sono stati cercati articoli completi nelle basi di dati di ricerca Scientific Electronic Library Online, Biblioteca Virtual em Sa\u00fade e PubMed, nelle lingue portoghese e inglese, ed \u00e8 stata impiegata la metodologia PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses), selezionando 14 articoli. Tra i risultati si evidenziano: la fisiopatogenesi della COVID-19 persistente si basa sulla teoria di fenomeni immuni secondari all\u2019infezione, risposta immunitaria anormale e presenza del virus in siti immunologicamente privilegiati; la fatica, la dispnea, il compromesso cognitivo soggettivo, le conseguenze neurologiche, le malattie infiammatorie del sistema nervoso centrale e la disfunzione olfattiva post-virale sono complicazioni prevalenti; sono state presentate prove di una relazione causale tra la COVID-19 e la tireoidite subacuta; \u00e8 stato dimostrato un maggior numero di complicazioni e ricoveri nei pazienti con carenza di vitamina D; cos\u00ec come la presenza di sintomi neuropsichiatrici nella popolazione di professionisti della salute. In conclusione, \u00e8 stata riscontrata la scarsit\u00e0 di lavori direttamente correlati alle conseguenze della COVID-19, rendendo necessario l\u2019approfondimento di tali ricerche al fine di sviluppare protocolli pi\u00f9 specifici per le diagnosi.<\/jats:p>","DOI":"10.32749\/nucleodoconhecimento.com.br\/salute\/squilibri-da-covid-19","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T17:01:24Z","timestamp":1698771684000},"page":"68-87","update-policy":"https:\/\/doi.org\/10.13003\/0pyd3js","source":"Crossref","is-referenced-by-count":0,"title":["Squilibri da COVID-19: revisione integrativa della letteratura"],"prefix":"10.32749","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3070-4823","authenticated-orcid":false,"given":"Luiz Thiago Oliveira","family":"Lopes","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9251-1263","authenticated-orcid":false,"given":"Marcelus de Andrade","family":"Oliveira","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2383-7695","authenticated-orcid":false,"given":"Willian Guilherme Lobato","family":"Gon\u00e7alves","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6249-0808","authenticated-orcid":false,"given":"Donizete Vago","family":"Daher","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8825-4923","authenticated-orcid":false,"given":"Irma da Silva","family":"Brito","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2952-4337","authenticated-orcid":false,"given":"Carla Viana","family":"Dendasck","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0840-6307","authenticated-orcid":false,"given":"Cl\u00e1udio Alberto Gellis de Mattos","family":"Dias","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5128-8903","authenticated-orcid":false,"given":"Amanda Alves","family":"Fecury","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7742-144X","authenticated-orcid":false,"given":"Maria Helena Mendon\u00e7a de","family":"Ara\u00fajo","sequence":"additional","affiliation":[]}],"member":"18045","published-online":{"date-parts":[[2023,8,8]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"AFAGHI, Siamak et al. 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