{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:29:09Z","timestamp":1791030549554,"version":"4.1.0"},"reference-count":37,"publisher":"Polish Society of Microbiologists","issue":"2","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    To explore the role of gut microbiota in Graves\u2019 disease (GD) and Hashimoto\u2019s thyroiditis (HT). Seventy fecal samples were collected, including 27 patients with GD, 27 with HT, and 16 samples from healthy volunteers. Chemiluminescence was used to detect thyroid function and autoantibodies (FT3, FT4, TSH, TRAb, TGAb, and TPOAb); thyroid ultrasound and 16S sequencing were used to analyze the bacteria in fecal samples; KEGG (Kyoto Encyclopedia of Genes and Genomes) and COG (Clusters of Orthologous Groups) were used to analyze the functional prediction and pathogenesis. The overall structure of gut microbiota in the GD and HT groups was significantly different from the healthy control group. Proteobacteria and Actinobacteria contents were the highest in the HT group. Compared to the control group, the GD and HT groups had a higher abundance of Erysipelotrichia, Cyanobacteria, and\n                    <jats:italic>Ruminococcus<\/jats:italic>\n                    _2 and lower levels of\n                    <jats:italic>Bacillaceae<\/jats:italic>\n                    and\n                    <jats:italic>Megamonas<\/jats:italic>\n                    . Further analysis of KEGG found that the \u201cABC transporter\u201d metabolic pathway was highly correlated with the occurrence of GD and HT. COG analysis showed that the GD and HT groups were enriched in carbohydrate transport and metabolism compared to the healthy control group but not in amino acid transport and metabolism. Our data suggested that\n                    <jats:italic>Bacillus<\/jats:italic>\n                    ,\n                    <jats:italic>Blautia<\/jats:italic>\n                    , and\n                    <jats:italic>Ornithinimicrobium<\/jats:italic>\n                    could be used as potential markers to distinguish GD and HT from the healthy population and that \u201cABC transporter\u201d metabolic pathway may be involved in the pathogenesis of GD and HT.\n                  <\/jats:p>","DOI":"10.33073\/pjm-2022-016","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T19:11:52Z","timestamp":1654715512000},"page":"173-189","source":"Crossref","is-referenced-by-count":40,"title":["Alterations and Mechanism of Gut Microbiota in Graves\u2019 Disease and Hashimoto\u2019s Thyroiditis"],"prefix":"10.33073","volume":"71","author":[{"given":"Hong","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Endocrine, Xiang\u2019an Hospital of Xiamen University , Xiamen , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijie","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Technology, Xiamen Medical College , Xiamen , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongli","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Endocrine, Daqing Oilfield Hospital , Daqing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banghao","family":"Sun","sequence":"additional","affiliation":[{"name":"Basic Medical College, Xinjiang Medical University , Wulumuqi , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Zhuhai People\u2019s Hospital , Zhuhai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Xiang\u2019an Hospital of Xiamen University , Xiamen , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18083","published-online":{"date-parts":[[2022,6,9]]},"reference":[{"key":"2026042905494976290_j_pjm-2022-016_ref_001","doi-asserted-by":"crossref","unstructured":"Ajjan RA, Weetman AP. 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