{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T13:29:01Z","timestamp":1787146141091,"version":"build-2736575974"},"reference-count":52,"publisher":"Polish Society of Microbiologists","issue":"3","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Whole-genome sequencing and genome mining are recently considered an efficient approach to shine more light on the underlying secondary metabolites of\n                    <jats:italic>Streptomyces<\/jats:italic>\n                    . The present study unearths the biosynthetic potential of endophytic SX6 as a promising source of biologically active substances and plant-derived compounds for the first time. Out of 38 isolates associated with\n                    <jats:italic>Aegiceras corniculatum<\/jats:italic>\n                    (L.) Blanco,\n                    <jats:italic>Streptomyces parvulus<\/jats:italic>\n                    SX6 was highly active against\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    ATCC\u00ae 9027\u2122 and methicillin-resistant\n                    <jats:italic>Staphylococcus epidermidis<\/jats:italic>\n                    (MRSE) ATCC\u00ae 35984\u2122. Additionally,\n                    <jats:italic>S. parvulus<\/jats:italic>\n                    SX6 culture extract showed strong cytotoxicity against Hep3B, MCF-7, and A549 cell lines at a concentration of 30 \u03bcg\/ml, but not in non-cancerous HEK-293 cells. The genome contained 7.69 Mb in size with an average G + C content of 72.8% and consisted of 6,779 protein-coding genes. AntiSMASH analysis resulted in the identification of 29 biosynthetic gene clusters (BGCs) for secondary metabolites. Among them, 4 BGCs showed low similarity (28\u201367% of genes show similarity) to actinomycin, streptovaricin, and polyoxypeptin gene clusters, possibly attributed to antibacterial and anticancer activities observed. In addition, the complete biosynthetic pathways of plant-derived compounds, including daidzein and genistein were identified using genome mining and HPLC-DAD-MS analysis. These findings portray an exciting avenue for future characterization of promising secondary metabolites from mangrove endophytic\n                    <jats:italic>S. parvulus<\/jats:italic>\n                    .\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/j_pjm-2022-034_eq_002.png\"\/>\n                  <\/jats:p>","DOI":"10.33073\/pjm-2022-034","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T05:07:22Z","timestamp":1664773642000},"page":"381-394","source":"Crossref","is-referenced-by-count":7,"title":["Genome-Guided Investigation Provides New Insights into Secondary Metabolites of\n                    <i>Streptomyces parvulus<\/i>\n                    SX6 from\n                    <i>Aegiceras corniculatum<\/i>"],"prefix":"10.33073","volume":"71","author":[{"given":"Ngoc Tung","family":"Quach","sequence":"first","affiliation":[{"name":"Graduate University of Science and Technology, Vietnam Academy of Science and Technology , Hanoi , Vietnam"},{"name":"Institute of Biotechnology, Vietnam Academy of Science and Technology , Hanoi , Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Hanh","family":"Nguyen Vu","sequence":"additional","affiliation":[{"name":"Graduate University of Science and Technology, Vietnam Academy of Science and Technology , Hanoi , Vietnam"},{"name":"Institute of Biotechnology, Vietnam Academy of Science and Technology , Hanoi , Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Lien","family":"Bui","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology, Vietnam Academy of Science and Technology , Hanoi , Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anh Tuan","family":"Pham","sequence":"additional","affiliation":[{"name":"Graduate University of Science and Technology, Vietnam Academy of Science and Technology , Hanoi , Vietnam"},{"name":"Institute of Biotechnology, Vietnam Academy of Science and Technology , Hanoi , Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Thu","family":"An Nguyen","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology, Vietnam Academy of Science and Technology , Hanoi , Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Thanh","family":"Xuan Le","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology, Vietnam Academy of Science and Technology , Hanoi , Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Thu","family":"Thuy Ta","sequence":"additional","affiliation":[{"name":"Hanoi Open University , Hanoi , Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pravin","family":"Dudhagara","sequence":"additional","affiliation":[{"name":"Department of Biosciences (UGC-SAP-II and DST-FIST-I), Veer Narmad South Gujarat University , Surat , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7182-3384","authenticated-orcid":false,"given":"Quyet-Tien","family":"Phi","sequence":"additional","affiliation":[{"name":"Graduate University of Science and Technology, Vietnam Academy of Science and Technology , Hanoi , Vietnam"},{"name":"Institute of Biotechnology, Vietnam Academy of Science and Technology , Hanoi , Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18083","published-online":{"date-parts":[[2022,9,24]]},"reference":[{"key":"2026081913033884905_j_pjm-2022-034_ref_001","doi-asserted-by":"crossref","unstructured":"Andrews JM. 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