{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T15:44:40Z","timestamp":1783957480522,"version":"3.55.0"},"reference-count":42,"publisher":"Polish Society of Microbiologists","issue":"4","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Graves\u2019 disease (GD) is an autoimmune disorder disease, and its prevalence continues to increase worldwide. Pyrroloquinoline quinone (PQQ) is a naturally antioxidant compound in milk, vegetables, and meat. We aim to identify the treatment efficacy of PQQ on GD and its regulatory effect on intestinal microbiota. The GD mice model was built by an adenovirus expressing autoantigen thyroid-stimulating hormone receptor (Ad-TSHR289). Fecal samples were collected for 16S rDNA sequencing after PQQ pretreatments (20, 40, or 60 mg\/kg BW\/day) for 4 weeks. Thyroid and intestine functions were measured. The levels of serum TSHR and T4 were significantly raised, and the thyroid gland size was typically enlarged in the GD group than in controls, reversed by PQQ therapy. After PQQ replenishment,\n                    <jats:italic>IL6<\/jats:italic>\n                    and\n                    <jats:italic>TNF\u03b1<\/jats:italic>\n                    levels in small intestine tissues were lower than those in the GD group, with\n                    <jats:italic>Nrf2<\/jats:italic>\n                    and\n                    <jats:italic>HO1<\/jats:italic>\n                    levels improved. Also, the PQQ supplement could maintain the mucosal epithelial barrier impaired by GD. In microbial analyses, PQQ treatment could prompt the diversity recovery of gut microbiota and reconstruct the microbiota composition injured by GD.\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    served as the most abundant genus in all groups, and the abundance of\n                    <jats:italic>Lactobacillu<\/jats:italic>\n                    s was increased in the GD group than in control and PQQ groups. Besides,\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    was highly correlative with all samples and the top 50 genera. PQQ supplementation regulates thyroid function and relieves intestine injury. PQQ changes the primary composition and abundance of GD\u2019s intestine microbiota by moderating\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    , which may exert in the pathogenesis and progression of GD.\n                  <\/jats:p>","DOI":"10.33073\/pjm-2023-042","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T05:37:51Z","timestamp":1702445871000},"page":"443-460","source":"Crossref","is-referenced-by-count":5,"title":["The Potential Role of Pyrroloquinoline Quinone to Regulate Thyroid Function and Gut Microbiota Composition of Graves\u2019 Disease in Mice"],"prefix":"10.33073","volume":"72","author":[{"given":"Xiaoyan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Shanghai Tenth Hospital, School of Clinical Medicine of Nanjing Medical University , Shanghai , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine , Shanghai , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganghua","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine , Shanghai , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine , Shanghai , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingwei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine , Shanghai , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine , Shanghai , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haidong","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine , Shanghai , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine , Shanghai , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanwan","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine , Shanghai , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongwei","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Shanghai Tenth Hospital, School of Clinical Medicine of Nanjing Medical University , Shanghai , People\u2019s Republic of China"},{"name":"Department of Nuclear Medicine, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine , Shanghai , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18083","published-online":{"date-parts":[[2023,12,16]]},"reference":[{"key":"2026042905515330522_j_pjm-2023-042_ref_001","doi-asserted-by":"crossref","unstructured":"Aldars-Garc\u00eda L, Chaparro M, Gisbert JP. 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