{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T09:17:38Z","timestamp":1785489458223,"version":"3.56.0"},"reference-count":214,"publisher":"National Institute for Health and Care Research","issue":"7","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.nationalarchives.gov.uk\/doc\/non-commercial-government-licence\/non-commercial-government-licence.htm"}],"funder":[{"DOI":"10.13039\/501100000664","name":"Health Technology Assessment programme","doi-asserted-by":"publisher","award":["09\/22\/122"],"award-info":[{"award-number":["09\/22\/122"]}],"id":[{"id":"10.13039\/501100000664","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Health Technol Assess"],"abstract":"<jats:sec id=\"abs1-1\"><jats:title>Background<\/jats:title><jats:p>Urodynamics (UDS) has been considered the gold standard test for detrusor overactivity (DO) in women with an overactive bladder (OAB). Bladder ultrasonography to measure bladder wall thickness (BWT) is less invasive and has been proposed as an alternative test.<\/jats:p><\/jats:sec><jats:sec id=\"abs1-2\"><jats:title>Objectives<\/jats:title><jats:p>To estimate the reliability, reproducibility, accuracy and acceptability of BWT in women with OAB, measured by ultrasonography, in the diagnosis of DO; to explore the role of UDS and its impact on treatment outcomes; and to conduct an economic evaluation of alternative care pathways.<\/jats:p><\/jats:sec><jats:sec id=\"abs1-3\"><jats:title>Design<\/jats:title><jats:p>A cross-sectional test accuracy study.<\/jats:p><\/jats:sec><jats:sec id=\"abs1-4\"><jats:title>Setting<\/jats:title><jats:p>22 UK hospitals.<\/jats:p><\/jats:sec><jats:sec id=\"abs1-5\"><jats:title>Participants<\/jats:title><jats:p>687 women with OAB.<\/jats:p><\/jats:sec><jats:sec id=\"abs1-6\"><jats:title>Methods<\/jats:title><jats:p>BWT was measured using transvaginal ultrasonography, and DO was assessed using UDS, which was performed blind to ultrasonographic findings. Intraobserver and interobserver reproducibility were assessed by repeated measurements from scans in 37 and 57 women, respectively, and by repeated scans in 27 women. Sensitivity and specificity were computed at pre-specified thresholds. The smallest real differences detectable of BWT were estimated using one-way analysis of variance. The pain and acceptability of both tests were evaluated by a questionnaire. Patient symptoms were measured before testing and after 6 and 12 months using the International Consultation on Incontinence modular Questionnaire Overactive Bladder (short form) (ICIQ-OAB) questionnaire and a global impression of improvement elicited at 12 months. Interventions and patient outcomes were analysed according to urodynamic diagnoses and BWT measurements. A decision-analytic model compared the cost-effectiveness of care strategies using UDS, ultrasonography or clinical history, estimating the cost per woman successfully treated and the cost per quality-adjusted life-year (QALY).<\/jats:p><\/jats:sec><jats:sec id=\"abs1-7\"><jats:title>Results<\/jats:title><jats:p>BWT showed very low sensitivity and specificity at all pre-specified cut-off points, and there was no evidence of discrimination at any threshold (<jats:italic>p<\/jats:italic>\u2009=\u20090.25). Extensive sensitivity and subgroup analyses did not alter the interpretation of these findings. The smallest detectable difference in BWT was estimated to be 2\u2009mm. Pain levels following both tests appeared relatively low. The proportion of women who found the test \u2018totally acceptable\u2019 was significantly higher with ultrasonography than UDS (81% vs. 56%;<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Overall, subsequent treatment was highly associated with urodynamic diagnosis (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). There was no evidence that BWT had any relationship with the global impression of improvement responses at 20 months (<jats:italic>p<\/jats:italic>\u2009=\u20090.4). Bladder ultrasonography was more costly and less effective than the other strategies. The incremental cost-effectiveness ratio (ICER) of basing treatment on the primary clinical presentation compared with UDS was \u00a3491,500 per woman successfully treated and \u00a360,200 per QALY. Performing a UDS in those women with a clinical history of mixed urinary incontinence had an ICER of \u00a319,500 per woman successfully treated and \u00a312,700 per QALY compared with the provision of urodynamic to all women. For DO cases detected, UDS was the most cost-effective strategy.<\/jats:p><\/jats:sec><jats:sec id=\"abs1-8\"><jats:title>Conclusion<\/jats:title><jats:p>There was no evidence that BWT had any relationship with DO, regardless of the cut-off point, nor any relationship to symptoms as measured by the ICIQ-OAB. Bladder ultrasonography has no diagnostic or prognostic value as a test in this condition. Furthermore, despite its greater acceptability, BWT measurement was not sufficiently reliable or reproducible.<\/jats:p><\/jats:sec><jats:sec id=\"abs1-9\"><jats:title>Trial registration<\/jats:title><jats:p>Current Controlled Trials ISRCTN46820623.<\/jats:p><\/jats:sec><jats:sec id=\"abs1-10\"><jats:title>Funding<\/jats:title><jats:p>This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in<jats:italic>Health Technology Assessment<\/jats:italic>; Vol. 20, No. 7. See the NIHR Journals Library website for further project information.<\/jats:p><\/jats:sec>","DOI":"10.3310\/hta20070","type":"journal-article","created":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T11:09:08Z","timestamp":1453892948000},"page":"1-150","update-policy":"https:\/\/doi.org\/10.3310\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":30,"title":["Bladder ultrasonography for diagnosing detrusor overactivity: test accuracy study and economic evaluation"],"prefix":"10.3310","volume":"20","clinical-trial-number":[{"clinical-trial-number":"isrctn46820623","registry":"10.18810\/isrctn","type":"results"}],"author":[{"given":"Suneetha","family":"Rachaneni","sequence":"first","affiliation":[{"name":"School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanteela","family":"McCooty","sequence":"additional","affiliation":[{"name":"Birmingham Women\u2019s NHS Foundation 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