{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:51:54Z","timestamp":1789498314482,"version":"build-2803163510"},"reference-count":85,"publisher":"National Institute for Health and Care Research","issue":"41","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.nationalarchives.gov.uk\/doc\/non-commercial-government-licence\/non-commercial-government-licence.htm"}],"funder":[{"DOI":"10.13039\/501100000664","name":"Health Technology Assessment programme","doi-asserted-by":"publisher","award":["08\/38\/01"],"award-info":[{"award-number":["08\/38\/01"]}],"id":[{"id":"10.13039\/501100000664","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Health Technol Assess"],"abstract":"<jats:sec id=\"abs1-1\"><jats:title>Background and objectives<\/jats:title><jats:p>Progesterone is essential to maintain a healthy pregnancy. Guidance from the Royal College of Obstetricians and Gynaecologists and a Cochrane review called for a definitive trial to test whether or not progesterone therapy in the first trimester could reduce the risk of miscarriage in women with a history of unexplained recurrent miscarriage (RM). The PROMISE trial was conducted to answer this question. A concurrent cost-effectiveness analysis was conducted.<\/jats:p><\/jats:sec><jats:sec id=\"abs1-2\"><jats:title>Design and setting<\/jats:title><jats:p>A randomised, double-blind, placebo-controlled, international multicentre study, with economic evaluation, conducted in hospital settings across the UK (36 sites) and in the Netherlands (nine sites).<\/jats:p><\/jats:sec><jats:sec id=\"abs1-3\"><jats:title>Participants and interventions<\/jats:title><jats:p>Women with unexplained RM (three or more first-trimester losses), aged between 18 and 39 years at randomisation, conceiving naturally and giving informed consent, received either micronised progesterone (Utrogestan<jats:sup>\u00ae<\/jats:sup>, Besins Healthcare) at a dose of 400\u2009mg (two vaginal capsules of 200\u2009mg) or placebo vaginal capsules twice daily, administered vaginally from soon after a positive urinary pregnancy test (and no later than 6 weeks of gestation) until 12 completed weeks of gestation (or earlier if the pregnancy ended before 12 weeks).<\/jats:p><\/jats:sec><jats:sec id=\"abs1-4\"><jats:title>Main outcome measures<\/jats:title><jats:p>Live birth beyond 24 completed weeks of gestation (primary outcome), clinical pregnancy at 6\u20138 weeks, ongoing pregnancy at 12 weeks, miscarriage, gestation at delivery, neonatal survival at 28 days of life, congenital abnormalities and resource use.<\/jats:p><\/jats:sec><jats:sec id=\"abs1-5\"><jats:title>Methods<\/jats:title><jats:p>Participants were randomised after confirmation of pregnancy. Randomisation was performed online via a secure internet facility. Data were collected on four occasions of outcome assessment after randomisation, up to 28 days after birth.<\/jats:p><\/jats:sec><jats:sec id=\"abs1-6\"><jats:title>Results<\/jats:title><jats:p>A total of 1568 participants were screened for eligibility. Of the 836 women randomised between 2010 and 2013, 404 received progesterone and 432 received placebo. The baseline data (age, body mass index, maternal ethnicity, smoking status and parity) of the participants were comparable in the two arms of the trial. The follow-up rate to primary outcome was 826 out of 836 (98.8%). The live birth rate in the progesterone group was 65.8% (262\/398) and in the placebo group it was 63.3% (271\/428), giving a relative risk of 1.04 (95% confidence interval 0.94 to 1.15;<jats:italic>p<\/jats:italic>\u2009=\u20090.45). There was no evidence of a significant difference between the groups for any of the secondary outcomes. Economic analysis suggested a favourable incremental cost-effectiveness ratio for decision-making but wide confidence intervals indicated a high level of uncertainty in the health benefits. Additional sensitivity analysis suggested the probability that progesterone would fall within the National Institute for Health and Care Excellence\u2019s threshold of \u00a320,000\u201330,000 per quality-adjusted life-year as between 0.7145 and 0.7341.<\/jats:p><\/jats:sec><jats:sec id=\"abs1-7\"><jats:title>Conclusions<\/jats:title><jats:p>There is no evidence that first-trimester progesterone therapy improves outcomes in women with a history of unexplained RM.<\/jats:p><\/jats:sec><jats:sec id=\"abs1-8\"><jats:title>Limitations<\/jats:title><jats:p>This study did not explore the effect of treatment with other progesterone preparations or treatment during the luteal phase of the menstrual cycle.<\/jats:p><\/jats:sec><jats:sec id=\"abs1-9\"><jats:title>Future work<\/jats:title><jats:p>Future research could explore the efficacy of progesterone supplementation administered during the luteal phase of the menstrual cycle in women attempting natural conception despite a history of RM.<\/jats:p><\/jats:sec><jats:sec id=\"abs1-10\"><jats:title>Trial registration<\/jats:title><jats:p>Current Controlled Trials ISRCTN92644181; EudraCT 2009-011208-42; Research Ethics Committee 09\/H1208\/44.<\/jats:p><\/jats:sec><jats:sec id=\"abs1-11\"><jats:title>Funding<\/jats:title><jats:p>This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in<jats:italic>Health Technology Assessment<\/jats:italic>; Vol. 20, No. 41. See the NIHR Journals Library website for further project information.<\/jats:p><\/jats:sec>","DOI":"10.3310\/hta20410","type":"journal-article","created":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T07:07:10Z","timestamp":1464246430000},"page":"1-92","update-policy":"https:\/\/doi.org\/10.3310\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":66,"title":["PROMISE: first-trimester progesterone therapy in women with a history of unexplained recurrent miscarriages \u2013 a randomised, double-blind, placebo-controlled, international multicentre trial and economic evaluation"],"prefix":"10.3310","volume":"20","clinical-trial-number":[{"clinical-trial-number":"isrctn92644181","registry":"10.18810\/isrctn","type":"results"}],"author":[{"given":"Arri","family":"Coomarasamy","sequence":"first","affiliation":[{"name":"College of Medical and Dental Sciences, University of Birmingham, Birmingham, 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