{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:21:08Z","timestamp":1762431668150,"version":"3.37.3"},"reference-count":35,"publisher":"National Institute for Health and Care Research","issue":"34","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.nationalarchives.gov.uk\/doc\/non-commercial-government-licence\/non-commercial-government-licence.htm"}],"funder":[{"DOI":"10.13039\/501100000664","name":"Health Technology Assessment programme","doi-asserted-by":"publisher","award":["13\/88\/13"],"award-info":[{"award-number":["13\/88\/13"]}],"id":[{"id":"10.13039\/501100000664","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIHR","award":["NIHR-RP-02-12-012"],"award-info":[{"award-number":["NIHR-RP-02-12-012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Health Technol Assess"],"abstract":"<jats:sec id=\"abs1-1\">\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Acute otitis media (AOM) is a common reason for primary care consultations and antibiotic prescribing in children. Options for improved pain control may influence antibiotic prescribing and consumption.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"abs1-2\">\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The Children\u2019s Ear Pain Study (CEDAR) investigated whether or not providing anaesthetic\u2013analgesic ear drops reduced antibiotic consumption in children with AOM. Secondary objectives included pain control and cost-effectiveness.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"abs1-3\">\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>A multicentre, randomised, parallel-group (two-group initially, then three-group) trial.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"abs1-4\">\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Primary care practices in England and Wales.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"abs1-5\">\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>1- to 10-year-old children presenting within 1 week of suspected AOM onset with ear pain during the preceding 24 hours and not requiring immediate antibiotics. Participating children were logged into the study and allocated using a remote randomisation service.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"abs1-6\">\n                  <jats:title>Interventions<\/jats:title>\n                  <jats:p>Two-group trial \u2013 unblinded comparison of anaesthetic\u2013analgesic ear drops versus usual care. Three-group trial \u2013 blinded comparison of anaesthetic\u2013analgesic ear drops versus placebo ear drops and unblinded comparison with usual care.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"abs1-7\">\n                  <jats:title>Main outcome measures<\/jats:title>\n                  <jats:p>The primary outcome measure was parent-reported antibiotic use by the child over 8 days following enrolment. Secondary measures included ear pain at day 2 and NHS and societal costs over 8 days.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"abs1-8\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Owing to a delay in provision of the placebo drops, the recruitment period was shortened and most participants were randomly allocated to the two-group study (<jats:italic>n<\/jats:italic>\u2009=\u200974) rather than the three-group study (<jats:italic>n<\/jats:italic>\u2009=\u200932). Comparing active drops with usual care in the combined two-group and three-group studies, 1 out of 39 (3%) children allocated to the active drops group and 11 out of 38 (29%) children allocated to the usual-care group consumed antibiotics in the 8 days following enrolment [unadjusted odds ratio 0.09, 95% confidence interval (CI) 0.02 to 0.55; <jats:italic>p<\/jats:italic>\u2009=\u20090.009; adjusted for delayed prescribing odds ratio 0.15, 95% CI 0.03 to 0.87; <jats:italic>p<\/jats:italic>\u2009=\u20090.035]. A total of 43% (3\/7) of patients in the placebo drops group consumed antibiotics by day 8, compared with 0% (0\/10) of the three-group study active drops groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.051). The economic analysis of NHS costs (\u00a312.66 for active drops and \u00a311.36 for usual care) leads to an estimated cost of \u00a35.19 per antibiotic prescription avoided, but with a high degree of uncertainty. A reduction in ear pain at day 2 in the placebo group (<jats:italic>n<\/jats:italic>\u2009=\u20097) compared with the active drops group (<jats:italic>n<\/jats:italic>\u2009=\u200910) (adjusted difference in means 0.67, 95% CI \u20131.44 to 2.79; <jats:italic>p<\/jats:italic>\u2009=\u20090.51) is consistent with chance. No adverse events were reported in children receiving active drops.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"abs1-9\">\n                  <jats:title>Limitations<\/jats:title>\n                  <jats:p>Estimated treatment effects are imprecise because the sample size target was not met. It is not clear if delayed prescriptions of an antibiotic were written prior to randomisation. Few children received placebo drops, which hindered the investigation of ear pain.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"abs1-10\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study suggests that reduced antibiotic use can be achieved in children with AOM by combining a no or delayed antibiotic prescribing strategy with anaesthetic\u2013analgesic ear drops. Whether or not the active drops relieved ear pain was not established.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"abs1-11\">\n                  <jats:title>Future work<\/jats:title>\n                  <jats:p>The observed reduction in antibiotic consumption following the prescription of ear drops requires replication in a larger study. Future work should establish if the effect of ear drops is due to pain relief.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"abs1-12\">\n                  <jats:title>Trial registration<\/jats:title>\n                  <jats:p>Current Controlled Trials ISRCTN09599764.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"abs1-13\">\n                  <jats:title>Funding<\/jats:title>\n                  <jats:p>This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in <jats:italic>Health Technology Assessment<\/jats:italic>; Vol. 23, No. 34. See the NIHR Journals Library website for further project information. Alastair D Hay was funded by a NIHR Research Professorship (funding identifier NIHR-RP-02-12-012).<\/jats:p>\n               <\/jats:sec>","DOI":"10.3310\/hta23340","type":"journal-article","created":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T11:34:45Z","timestamp":1563190485000},"page":"1-48","update-policy":"https:\/\/doi.org\/10.3310\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Anaesthetic\u2013analgesic ear drops to reduce antibiotic consumption in children with acute otitis media: the CEDAR RCT"],"prefix":"10.3310","volume":"23","clinical-trial-number":[{"clinical-trial-number":"isrctn09599764","registry":"10.18810\/isrctn","type":"results"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3012-375X","authenticated-orcid":true,"given":"Alastair D","family":"Hay","sequence":"first","affiliation":[{"name":"Centre for Academic Primary Care, Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, 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