{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T21:40:41Z","timestamp":1790458841257,"version":"4.1.0"},"reference-count":92,"publisher":"National Institute for Health and Care Research","issue":"58","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.nationalarchives.gov.uk\/doc\/non-commercial-government-licence\/non-commercial-government-licence.htm"}],"funder":[{"DOI":"10.13039\/501100000664","name":"Health Technology Assessment programme","doi-asserted-by":"publisher","award":["11\/94\/01"],"award-info":[{"award-number":["11\/94\/01"]}],"id":[{"id":"10.13039\/501100000664","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Health Technol Assess"],"abstract":"<jats:sec id=\"abs1-1\">\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Although strategies have been developed to minimise the risk of occupational hand dermatitis in nurses, their clinical effectiveness and cost-effectiveness remain unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"abs1-2\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The Skin Care Intervention in Nurses trial tested the hypothesis that a behaviour change package intervention, coupled with provision of hand moisturisers, could reduce the point prevalence of hand dermatitis when compared with standard care among nurses working in the NHS. The secondary aim was to assess the impact of the intervention on participants\u2019 beliefs and behaviour regarding hand care, and the cost-effectiveness of the intervention in comparison with normal care.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"abs1-3\">\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Cluster randomised controlled trial.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"abs1-4\">\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Thirty-five NHS hospital trusts\/health boards\/universities.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"abs1-5\">\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>First-year student nurses with a history of atopic tendency, and full-time intensive care unit nurses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"abs1-6\">\n                  <jats:title>Intervention<\/jats:title>\n                  <jats:p>Sites were randomly allocated to be \u2018intervention plus\u2019 or \u2018intervention light\u2019. Participants at \u2018intervention plus\u2019 sites received access to a bespoke online behaviour change package intervention, coupled with personal supplies of moisturising cream (student nurses) and optimal availability of moisturising cream (intensive care unit nurses). Nurses at \u2018intervention light\u2019 sites received usual care, including a dermatitis prevention leaflet.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"abs1-7\">\n                  <jats:title>Main outcome measure<\/jats:title>\n                  <jats:p>The difference between intervention plus and intervention light sites in the change of point prevalence of visible hand dermatitis was measured from images taken at baseline and at follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"abs1-8\">\n                  <jats:title>Randomisation<\/jats:title>\n                  <jats:p>Fourteen sites were randomised to the intervention plus arm, and 21 sites were randomised to the intervention light arm.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"abs1-9\">\n                  <jats:title>Blinding<\/jats:title>\n                  <jats:p>The participants, trial statistician, methodologist and the dermatologists interpreting the hand photographs were blinded to intervention assignment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"abs1-10\">\n                  <jats:title>Numbers analysed<\/jats:title>\n                  <jats:p>An intention-to-treat analysis was conducted on data from 845 student nurses and 1111 intensive care unit nurses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"abs1-11\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The intention-to-treat analysis showed no evidence that the risk of developing dermatitis was greater in the intervention light group than in the intervention plus group (student nurses: odds ratio 1.25, 95% confidence interval 0.59 to 2.69; intensive care unit nurses: odds ratio 1.41, 95% confidence interval 0.81 to 2.44). Both groups had high levels of baseline beliefs about the benefits of using hand moisturisers before, during and after work. The frequency of use of hand moisturisers before, during and after shifts was significantly higher in the intensive care unit nurses in the intervention plus arm at follow-up than in the comparator group nurses. For student nurses, the intervention plus group mean costs were \u00a32 lower than those for the comparator and 0.00002 more quality-adjusted life-years were gained. For intensive care unit nurses, costs were \u00a34 higher and 0.0016 fewer quality-adjusted life-years were gained.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"abs1-12\">\n                  <jats:title>Harms<\/jats:title>\n                  <jats:p>No adverse events were reported.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"abs1-13\">\n                  <jats:title>Limitations<\/jats:title>\n                  <jats:p>Only 44.5% of participants in the intervention plus arm accessed the behaviour change package.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"abs1-14\">\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The intervention did not result in a statistically significant decrease in the prevalence of hand dermatitis in the intervention plus group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"abs1-15\">\n                  <jats:title>Future work<\/jats:title>\n                  <jats:p>Participants had a high level of baseline beliefs about the importance of using hand moisturisers before, during and after work. Future research should focus on how workplace culture can be changed in order for that knowledge to be actioned.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"abs1-16\">\n                  <jats:title>Trial registration<\/jats:title>\n                  <jats:p>Current Controlled Trials ISRCTN53303171.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"abs1-17\">\n                  <jats:title>Funding<\/jats:title>\n                  <jats:p>This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in <jats:italic>Health Technology Assessment<\/jats:italic>; Vol. 23, No. 58. See the NIHR Journals Library website for further project information.<\/jats:p>\n               <\/jats:sec>","DOI":"10.3310\/hta23580","type":"journal-article","created":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T08:57:22Z","timestamp":1571734642000},"page":"1-92","update-policy":"https:\/\/doi.org\/10.3310\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["A behaviour change package to prevent hand dermatitis in nurses working in health care: the SCIN cluster RCT"],"prefix":"10.3310","volume":"23","clinical-trial-number":[{"clinical-trial-number":"isrctn53303171","registry":"10.18810\/isrctn","type":"results"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2200-7329","authenticated-orcid":true,"given":"Ira","family":"Madan","sequence":"first","affiliation":[{"name":"Occupational Health Service, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust, London, UK"},{"name":"King\u2019s College London, London, 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