{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T03:08:56Z","timestamp":1776308936477,"version":"3.50.1"},"reference-count":57,"publisher":"National Institute for Health and Care Research","issue":"11","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.nationalarchives.gov.uk\/doc\/non-commercial-government-licence\/non-commercial-government-licence.htm"}],"funder":[{"DOI":"10.13039\/501100000664","name":"Health Technology Assessment programme","doi-asserted-by":"publisher","award":["10\/104\/06"],"award-info":[{"award-number":["10\/104\/06"]}],"id":[{"id":"10.13039\/501100000664","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journalslibrary.nihr.ac.uk"],"crossmark-restriction":false},"short-container-title":["Health Technol Assess"],"abstract":"\n Background<\/jats:title>\n Anaemia affects 30\u201350% of patients before they undergo major surgery. Preoperative anaemia is associated with increased need for blood transfusion, postoperative complications and worse patient outcomes after surgery. International guidelines support the use of intravenous iron to correct anaemia in patients before surgery. However, the use of preoperative intravenous iron for patient benefit has not been assessed in the setting of a formal clinical trial.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n To assess if intravenous iron given to patients with anaemia before major abdominal surgery is beneficial by reducing transfusion rates, postoperative complications, hospital stay and re-admission to hospital, and improving quality of life outcomes.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n A multicentre, double-blinded, randomised, controlled, Phase III clinical trial, with 1 : 1 randomisation comparing placebo (normal saline) with intravenous iron (intravenous ferric carboxymaltose 1000\u2009mg). Randomisation and treatment allocation were by a secure web-based service.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n The study was conducted across 46 hospitals in England, Scotland and Wales between September 2013 and September 2018.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n Patients aged >\u200918 years, undergoing elective major open abdominal surgery, with anaemia [Hb level of >\u200990\u2009g\/l and <\u2009120\u2009g\/l (female patients) and <\u2009130\u2009g\/l (male patients)] who could undergo randomisation and treatment 10\u201342 days before their operation.<\/jats:p>\n <\/jats:sec>\n \n Intervention<\/jats:title>\n Double-blinded study comparing placebo of normal saline with 1000\u2009mg of ferric carboxymaltose administered 10\u201342 days prior to surgery.<\/jats:p>\n <\/jats:sec>\n \n Main outcome measures<\/jats:title>\n Co-primary end points were risk of blood transfusion or death at 30 days postoperatively, and rate of blood transfusions at 30 days post operation.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n A total of 487 patients were randomised (243 given placebo and 244 given intravenous iron), of whom 474 completed the trial and provided data for the analysis of the co-primary end points. The use of intravenous iron increased preoperative Hb levels (mean difference 4.7\u2009g\/l, 95% confidence interval 2.7 to 6.8 g\/l; p<\/jats:italic>\u2009<\u20090.0001), but had no effect compared with placebo on risk of blood transfusion or death (risk ratio 1.03, 95% confidence interval 0.78 to 1.37; p<\/jats:italic>\u2009=\u20090.84; absolute risk difference +0.8%, 95% confidence interval \u20137.3% to 9.0%), or rates of blood transfusion (rate ratio 0.98, 95% confidence interval 0.68 to 1.43; p<\/jats:italic>\u2009=\u20090.93; absolute rate difference 0.00, 95% confidence interval \u20130.14 to 0.15). There was no difference in postoperative complications or hospital stay. The intravenous iron group had higher Hb levels at the 8-week follow-up (difference in mean 10.7\u2009g\/l, 95% confidence interval 7.8 to 13.7 g\/l; p<\/jats:italic>\u2009<\u20090.0001). There were a total of 71 re-admissions to hospital for postoperative complications in the placebo group, compared with 38 re-admissions in the intravenous iron group (rate ratio 0.54, 95% confidence interval 0.34 to 0.85; p<\/jats:italic>\u2009=\u20090.009). There were no differences between the groups in terms of mortality (two per group at 30 days post operation) or in any of the prespecified safety end points or serious adverse events.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n In patients with anaemia prior to elective major abdominal surgery, there was no benefit from giving intravenous iron before the operation.<\/jats:p>\n <\/jats:sec>\n \n Future work<\/jats:title>\n The impact of iron repletion on recovery from postoperative anaemia, and the association with reduced re-admission to hospital for complications, should be investigated.<\/jats:p>\n <\/jats:sec>\n \n Limitations<\/jats:title>\n In the preoperative intravenous iron to treat anaemia in major surgery (PREVENTT) trial, all patients included had anaemia and only 20% had their anaemia corrected before surgery. The definition and causality of iron deficiency in this setting is not clear.<\/jats:p>\n <\/jats:sec>\n \n Trial registration<\/jats:title>\n Current Controlled Trials ISRCTN67322816 and ClinicalTrials.gov NCT01692418.<\/jats:p>\n <\/jats:sec>\n \n Funding<\/jats:title>\n This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment<\/jats:italic>; Vol. 25 No. 11. See the NIHR Journals Library website for further project information.<\/jats:p>\n <\/jats:sec>","DOI":"10.3310\/hta25110","type":"journal-article","created":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T16:20:13Z","timestamp":1614270013000},"page":"1-58","update-policy":"https:\/\/doi.org\/10.3310\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Preoperative intravenous iron for anaemia in elective major open abdominal surgery: the PREVENTT RCT"],"prefix":"10.3310","volume":"25","clinical-trial-number":[{"clinical-trial-number":"isrctn67322816","registry":"10.18810\/isrctn","type":"results"},{"clinical-trial-number":"nct01692418","registry":"10.18810\/clinical-trials-gov","type":"results"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9872-4653","authenticated-orcid":true,"given":"Toby","family":"Richards","sequence":"first","affiliation":[{"name":"Division of Surgery, University of Western Australia, Perth, WA, Australia"},{"name":"Institute of 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