{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T02:00:53Z","timestamp":1772244053200,"version":"3.50.1"},"update-to":[{"DOI":"10.3310\/nihropenres.13357.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T00:00:00Z","timestamp":1683676800000}}],"reference-count":50,"publisher":"National Institute for Health and Care Research","license":[{"start":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T00:00:00Z","timestamp":1683676800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nationalarchives.gov.uk\/doc\/open-government-licence\/version\/3\/"}],"funder":[{"DOI":"10.13039\/501100009128","name":"Research for Patient Benefit Programme","doi-asserted-by":"publisher","award":["PB-PG-0211-24147"],"award-info":[{"award-number":["PB-PG-0211-24147"]}],"id":[{"id":"10.13039\/501100009128","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["openresearch.nihr.ac.uk"],"crossmark-restriction":false},"short-container-title":["NIHR Open Res"],"abstract":"<ns5:p>\n                    <ns5:bold>Background:<\/ns5:bold>\n                    There remains uncertainty about the definition of normal blood pressure (BP), and when to initiate treatment for hypotension for extremely preterm infants. To determine the short-term outcomes of extremely preterm infants managed by active compared with permissive BP support regimens during the first 72 hours of life.\n                  <\/ns5:p>\n                  <ns5:p>\n                    <ns5:bold>Method:<\/ns5:bold>\n                    This is a retrospective medical records review of 23\n                    <ns5:sup>+0<\/ns5:sup>\n                    \u201328\n                    <ns5:sup>+6<\/ns5:sup>\n                    weeks\u2019 gestational age (GA) infants admitted to neonatal units (NNU) with active BP support (aimed to maintain mean arterial BP (MABP) &gt;30 mmHg irrespective of the GA) and permissive BP support (used medication only when babies developed signs of hypotension) regimens. Babies admitted after 12 hours of age, or whose BP data were not available were excluded.\n                  <\/ns5:p>\n                  <ns5:p>\n                    <ns5:bold>Results:<\/ns5:bold>\n                    There were 764 infants admitted to the participating hospitals; 671 (88%) were included in the analysis (263\n                    <ns5:bold>active BP support<\/ns5:bold>\n                    and 408\n                    <ns5:bold>permissive BP support<\/ns5:bold>\n                    ). The mean gestational age, birth weight, admission temperature, clinical risk index for babies (CRIB) score and first haemoglobin of infants were comparable between the groups. Active BP support group infants had consistently higher MABP and systolic BP throughout the first 72 hours of life (p&lt;0.01). In the active group compared to the permissive group 56 (21.3%) vs 104 (25.5%) babies died, and 21 (8%) vs 51 (12.5%) developed &gt;grade 2 intra ventricular haemorrhage (IVH). Death before discharge (adjusted OR 1.38 (0.88 \u2013 2.16)) or IVH (1.38 (0.96 \u2013 1.98)) was similar between the two groups. Necrotising enterocolitis (NEC) \u2265stage 2 was significantly higher in permissive BP support group infants (1.65 (1.07 \u2013 2.50)).\n                  <\/ns5:p>\n                  <ns5:p>\n                    <ns5:bold>Conclusions<\/ns5:bold>\n                    : There was no difference in mortality or IVH between the two BP management approaches. Active BP support may reduce NEC. This should be investigated prospectively in large multicentre randomised studies.\n                  <\/ns5:p>","DOI":"10.3310\/nihropenres.13357.2","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T05:23:27Z","timestamp":1683696207000},"page":"7","update-policy":"https:\/\/doi.org\/10.3310\/nihropenres.crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of clinical outcomes between active and permissive blood pressure management in extremely preterm infants"],"prefix":"10.3310","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9140-4278","authenticated-orcid":false,"given":"Narendra","family":"Aladangady","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5201-7718","authenticated-orcid":false,"given":"Ajay","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7765-8439","authenticated-orcid":false,"given":"Jayanta","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Asamoah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asha","family":"Mathew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7381-8776","authenticated-orcid":false,"given":"Phillippa","family":"Chisholm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4080-3700","authenticated-orcid":false,"given":"Steven","family":"Kempley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7164-612X","authenticated-orcid":false,"given":"Joan","family":"Morris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6221","published-online":{"date-parts":[[2023,5,10]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"563-574","DOI":"10.1016\/j.clp.2020.05.011","article-title":"Intervention and Outcome for Neonatal Hypotension.","volume":"47","author":"K Barrington","year":"2020","journal-title":"Clin Perinatol."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"577-587","DOI":"10.1038\/hr.2015.45","article-title":"Strengths and limitations of current pediatric blood pressure nomograms: a global overview with a special emphasis on regional differences in neonates and infants.","volume":"38","author":"M Cantinotti","year":"2015","journal-title":"Hypertens Res."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"F388-F392","DOI":"10.1136\/archdischild-2014-306483","article-title":"Short-term outcome of very-low-birthweight infants with arterial hypotension in the first 24 h of life.","volume":"100","author":"K Faust","year":"2015","journal-title":"Arch Dis Child Fetal Neonatal Ed."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"698-702","DOI":"10.1038\/jp.2013.44","article-title":"Observational study of cerebral hemodynamics during dopamine treatment in hypotensive ELBW infants on the first day of life.","volume":"33","author":"M Lightburn","year":"2013","journal-title":"J Perinatol."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"F241-F244","DOI":"10.1136\/adc.2007.124263","article-title":"Permissive hypotension in the extremely low birthweight infant with signs of good perfusion.","volume":"94","author":"E Dempsey","year":"2009","journal-title":"Arch Dis Child Fetal Neonatal Ed."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"F298-F305","DOI":"10.1136\/archdischild-2017-314159","article-title":"Blood pressure intervention levels in preterm infants: pilot randomised trial.","volume":"104","author":"S Pereira","year":"2019","journal-title":"Arch Dis Child Fetal Neonatal Ed."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"1068-1069","DOI":"10.1136\/adc.62.10.1068","article-title":"Mean arterial blood pressure and neonatal cerebral lesions.","volume":"62","author":"V Miall-Allen","year":"1987","journal-title":"Arch Dis Child."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"822-828","DOI":"10.1038\/s41390-021-01839-2","article-title":"Early arterial pressure monitoring and term-equivalent age MRI findings in very preterm infants.","volume":"92","author":"R Butticci","year":"2022","journal-title":"Pediatr Res."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"986-991","DOI":"10.1016\/j.jpeds.2013.12.042","article-title":"Hypotension in Preterm Neonates: Low Blood Pressure Alone Does Not Affect Neurodevelopmental Outcome.","volume":"164","author":"T Alderliesten","year":"2014","journal-title":"J Pediatr."},{"key":"ref-10","doi-asserted-by":"publisher","first-page":"337-341","DOI":"10.1542\/peds.102.2.337","article-title":"Cerebral Blood Flow Is Independent of Mean Arterial Blood Pressure in Preterm Infants Undergoing Intensive Care.","volume":"102","author":"L Tyszczuk","year":"1998","journal-title":"Pediatrics."},{"key":"ref-11","doi-asserted-by":"publisher","first-page":"625-632","DOI":"10.1542\/peds.106.4.625","article-title":"Cerebral Intravascular Oxygenation Correlates With Mean Arterial Pressure in Critically Ill Premature Infants.","volume":"106","author":"M Tsuji","year":"2000","journal-title":"Pediatrics."},{"key":"ref-12","doi-asserted-by":"publisher","first-page":"1591-1596","DOI":"10.1542\/peds.2004-1073","article-title":"Hypotensive Extremely Low Birth Weight Infants Have Reduced Cerebral Blood Flow.","volume":"114","author":"M Munro","year":"2004","journal-title":"Pediatrics."},{"key":"ref-13","doi-asserted-by":"publisher","first-page":"607-614","DOI":"10.1016\/s0022-3476(05)80700-0","article-title":"Mean arterial blood pressure changes in premature infants and those at risk for intraventricular hemorrhage.","volume":"117","author":"H Bada","year":"1990","journal-title":"J Pediatr."},{"key":"ref-14","doi-asserted-by":"publisher","first-page":"e1865-e1873","DOI":"10.1542\/peds.2012-2779","article-title":"Use of Antihypotensive Therapies in Extremely Preterm Infants.","volume":"131","author":"B Batton","year":"2013","journal-title":"Pediatrics."},{"key":"ref-15","doi-asserted-by":"publisher","first-page":"F201-F206","DOI":"10.1136\/archdischild-2015-308899","article-title":"Early blood pressure, antihypotensive therapy and outcomes at 18-22 months' corrected age in extremely preterm infants.","volume":"101","author":"B Batton","year":"2016","journal-title":"Arch Dis Child Fetal Neonatal Ed."},{"key":"ref-16","doi-asserted-by":"publisher","first-page":"793-8","DOI":"10.1007\/s00431-013-2251-9","article-title":"International survey on diagnosis and management of hypotension in extremely preterm babies.","volume":"173","author":"Z Stranak","year":"2014","journal-title":"Eur J Pediatr."},{"key":"ref-17","first-page":"152-154","article-title":"Management of neonatal hypotension \u2013 a national questionnaire survey.","volume":"6","author":"S Bhojani","year":"2010","journal-title":"Infant."},{"key":"ref-18","doi-asserted-by":"publisher","first-page":"677-681","DOI":"10.1038\/sj.jp.7211579","article-title":"Diagnostic criteria and therapeutic interventions for the hypotensive very low birth weight infant.","volume":"26","author":"E Dempsey","year":"2006","journal-title":"J Perinatol."},{"key":"ref-19","doi-asserted-by":"publisher","first-page":"317-323","DOI":"10.1111\/j.1440-1754.2011.02246.x","article-title":"Cardiovascular support in preterm infants: A survey of practices in Australia and New Zealand.","volume":"48","author":"A Sehgal","year":"2012","journal-title":"J Paediatr Child Health."},{"key":"ref-20","doi-asserted-by":"publisher","first-page":"647-655","DOI":"10.1038\/jp.2011.2","article-title":"A meta-analysis of dopamine use in hypotensive preterm infants: blood pressure and cerebral hemodynamics.","volume":"31","author":"S Sassano-Higgins","year":"2011","journal-title":"J Perinatol."},{"key":"ref-21","doi-asserted-by":"publisher","first-page":"e1213-e1222","DOI":"10.1542\/peds.2005-2108","article-title":"Dopamine Versus Epinephrine for Cardiovascular Support in Low Birth Weight Infants: Analysis of Systemic Effects and Neonatal Clinical Outcomes.","volume":"117","author":"E Valverde","year":"2006","journal-title":"Pediatrics."},{"key":"ref-22","doi-asserted-by":"publisher","first-page":"398-403","DOI":"10.1136\/archdischild-2020-320241","article-title":"Hypotension in Preterm Infants (HIP) randomised trial.","volume":"106","author":"E Dempsey","year":"2021","journal-title":"Arch Dis Child Fetal Neonatal Ed."},{"key":"ref-23","doi-asserted-by":"publisher","first-page":"1-7","DOI":"10.1097\/00000658-197801000-00001","article-title":"Neonatal Necrotizing Enterocolitis. Therapeutic Decisions Based upon Clinical Staging.","volume":"187","author":"M Bell","year":"1978","journal-title":"Ann Surg."},{"key":"ref-24","doi-asserted-by":"publisher","first-page":"1723-1729","DOI":"10.1164\/ajrccm.163.7.2011060","article-title":"Bronchopulmonary Dysplasia.","volume":"163","author":"A Jobe","year":"2001","journal-title":"Am J Respir Crit Care Med."},{"key":"ref-26","doi-asserted-by":"publisher","first-page":"242-248","DOI":"10.1016\/j.jpeds.2018.07.096","article-title":"Optimal Mean Arterial Blood Pressure in Extremely Preterm Infants within the First 24 Hours of Life.","volume":"203","author":"C da Costa","year":"2018","journal-title":"J Pediatr."},{"key":"ref-27","doi-asserted-by":"publisher","first-page":"e7976","DOI":"10.1136\/bmj.e7976","article-title":"Short term outcomes after extreme preterm birth in England: Comparison of two birth cohorts in 1995 and 2006 (the EPICure studies).","volume":"345","author":"K Costeloe","year":"2012","journal-title":"BMJ."},{"key":"ref-28","doi-asserted-by":"publisher","first-page":"490-496","DOI":"10.1136\/archdischild-2016-312104","article-title":"Abstention or intervention for isolated hypotension in the first 3 days of life in extremely preterm infants: association with short-term outcomes in the EPIPAGE 2 cohort study.","volume":"102","author":"X Durrmeyer","year":"2017","journal-title":"Arch Dis Child Fetal Neonatal Ed."},{"key":"ref-29","doi-asserted-by":"publisher","first-page":"179","DOI":"10.3389\/fped.2020.00179","article-title":"Risk Factors for Necrotizing Enterocolitis in Infants With Patent Arterial Duct. A Retrospective Matched Paired Analysis.","volume":"8","author":"S Haefeli","year":"2020","journal-title":"Front Pediatr."},{"key":"ref-30","doi-asserted-by":"publisher","first-page":"e11739","DOI":"10.1097\/MD.0000000000011739","article-title":"Maternal pregnancy-induced hypertension increases subsequent neonatal necrotizing enterocolitis risk: A nationwide population-based retrospective cohort study in Taiwan.","volume":"97","author":"C Yang","year":"2018","journal-title":"Medicine (Baltimore)."},{"key":"ref-31","doi-asserted-by":"publisher","first-page":"335-342","DOI":"10.1111\/j.1748-1716.1979.tb06407.x","article-title":"Intramural blood flows and flow distribution in the feline small intestine during arterial hypotension.","volume":"106","author":"J Cassuto","year":"1979","journal-title":"Acta Physiol Scand."},{"key":"ref-32","doi-asserted-by":"publisher","first-page":"193-209","DOI":"10.1111\/j.1748-1716.1984.tb07448.x","article-title":"Blood flow distribution, villous tissue osmolality and fluid and electrolyte transport in the cat small intestine during regional hypotension.","volume":"121","author":"S Redfors","year":"1984","journal-title":"Acta Physiol Scand."},{"key":"ref-33","doi-asserted-by":"publisher","first-page":"399-408","DOI":"10.1111\/vox.12436","article-title":"Blood transfusion in preterm infants improves intestinal tissue oxygenation without alteration in blood flow.","volume":"111","author":"J Banerjee","year":"2016","journal-title":"Vox Sang."},{"key":"ref-34","article-title":"Blood Transfusion Causes More Profound Changes In Splanchnic Oxygenation Compared With Brain","author":"C Murphy"},{"key":"ref-35","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s12916-014-0247-6","article-title":"Haemoglobin level at birth is associated with short term outcomes and mortality in preterm infants.","volume":"13","author":"J Banerjee","year":"2015","journal-title":"BMC Med."},{"key":"ref-36","article-title":"National Neonatal Audit Programme Annual Report 2020 - on 2019 Data.","year":"2020"},{"key":"ref-37","doi-asserted-by":"publisher","first-page":"l5678","DOI":"10.1136\/bmj.l5678","article-title":"Association of early postnatal transfer and birth outside a tertiary hospital with mortality and severe brain injury in extremely preterm infants: observational cohort study with propensity score matching.","volume":"367","author":"K Helenius","year":"2019","journal-title":"BMJ."},{"key":"ref-38","doi-asserted-by":"publisher","first-page":"659-71","DOI":"10.1542\/peds.106.4.659","article-title":"The EPICure Study: Outcomes to Discharge From Hospital for Infants Born at the Threshold of Viability.","volume":"106","author":"K Costeloe","year":"2000","journal-title":"Pediatrics."},{"key":"ref-39","doi-asserted-by":"publisher","first-page":"7-16","DOI":"10.1159\/000486584","article-title":"Red Blood Cell Transfusion in Preterm Infants: Current Evidence and Controversies.","volume":"114","author":"C Howarth","year":"2018","journal-title":"Neonatology."},{"key":"ref-40","doi-asserted-by":"publisher","first-page":"437-444","DOI":"10.5863\/1551-6776-25.5.437","article-title":"Effect of Fluid Bolus on Clinical Outcomes in Very Low Birth Weight Infants.","volume":"25","author":"S Bakshi","year":"2020","journal-title":"J Pediatr Pharmacol Ther."},{"key":"ref-41","doi-asserted-by":"publisher","first-page":"F38-F42","DOI":"10.1136\/fn.80.1.f38","article-title":"Systolic blood pressure in babies of less than 32 weeks gestation in the first year of life. Northern Neonatal Nursing Initiative.","volume":"80","year":"1999","journal-title":"Arch Dis Child - Fetal Neonatal Ed."},{"key":"ref-42","doi-asserted-by":"publisher","first-page":"291-295","DOI":"10.1038\/jp.2015.185","article-title":"Empirical estimation of the normative blood pressure in infants <28 weeks gestation using a massive data approach.","volume":"36","author":"Z Vesoulis","year":"2016","journal-title":"J Perinatol."},{"key":"ref-43","doi-asserted-by":"publisher","first-page":"1386-1390","DOI":"10.1038\/s41372-018-0184-x","article-title":"Racial\/ethnic differences in necrotizing enterocolitis incidence and outcomes in premature very low birth weight infants.","volume":"38","author":"M Jammeh","year":"2018","journal-title":"J Perinatol."},{"key":"ref-44","doi-asserted-by":"publisher","first-page":"3-9","DOI":"10.1038\/s41390-020-1073-5","article-title":"Racial\/ethnic disparities and human milk use in necrotizing enterocolitis.","volume":"88","author":"G Goldstein","year":"2020","journal-title":"Pediatr Res."},{"key":"ref-45","doi-asserted-by":"publisher","first-page":"633088","DOI":"10.3389\/fped.2021.633088","article-title":"Racial Disparities in Necrotizing Enterocolitis.","volume":"9","author":"A Cuna","year":"2021","journal-title":"Front Pediatr."},{"key":"ref-46","doi-asserted-by":"publisher","first-page":"590578","DOI":"10.3389\/fped.2020.590578","article-title":"Management of Patent Ductus Arteriosus in Premature Infants in 2020.","volume":"8","author":"S Parkerson","year":"2021","journal-title":"Front Pediatr."},{"key":"ref-47","doi-asserted-by":"publisher","first-page":"1660-1661","DOI":"10.1016\/S0140-6736(04)16285-5","article-title":"Beyond randomised versus observational studies.","volume":"363","author":"J Concato","year":"2004","journal-title":"Lancet."},{"key":"ref-48","doi-asserted-by":"publisher","first-page":"694-699","DOI":"10.1080\/10253890.2020.1806227","article-title":"Relationships between antenatal corticosteroids and catecholamine blood pressure support in neonates: considering of maternal stress-related diseases.","volume":"23","author":"A Garafova","year":"2020","journal-title":"Stress."},{"key":"ref-49","doi-asserted-by":"publisher","first-page":"829-834","DOI":"10.1111\/j.1651-2227.1989.tb11158.x","article-title":"Investigation of the Effects of Paralysis by Pancuronium on Heart Rate Variability, Blood Pressure and Fluid Balance.","volume":"78","author":"A Greenough","year":"1989","journal-title":"Acta Paediatr Scand."},{"key":"ref-50","doi-asserted-by":"publisher","first-page":"F46-F51","DOI":"10.1136\/adc.2004.069831","article-title":"Morphine in ventilated neonates: its effects on arterial blood pressure.","volume":"91","author":"S Simons","year":"2006","journal-title":"Arch Dis Child Fetal Neonatal Ed."},{"key":"ref-51","doi-asserted-by":"publisher","first-page":"CD003248","DOI":"10.1002\/14651858.CD003248.pub4","article-title":"Effect of timing of umbilical cord clamping and other strategies to influence placental transfusion at preterm birth on maternal and infant outcomes.","volume":"9","author":"H Rabe","year":"2019","journal-title":"Cochrane Database Syst Rev."}],"container-title":["NIHR Open Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/openresearch.nihr.ac.uk\/articles\/3-7\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openresearch.nihr.ac.uk\/articles\/3-7\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/openresearch.nihr.ac.uk\/articles\/3-7\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T11:53:47Z","timestamp":1692100427000},"score":1,"resource":{"primary":{"URL":"https:\/\/openresearch.nihr.ac.uk\/articles\/3-7\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,10]]},"references-count":50,"URL":"https:\/\/doi.org\/10.3310\/nihropenres.13357.2","relation":{"has-review":[{"id-type":"doi","id":"10.3310\/nihropenres.14572.r29254","asserted-by":"subject"},{"id-type":"doi","id":"10.3310\/nihropenres.14572.r29255","asserted-by":"subject"},{"id-type":"doi","id":"10.3310\/nihropenres.14572.r29254","asserted-by":"object"},{"id-type":"doi","id":"10.3310\/nihropenres.14572.r29255","asserted-by":"object"}]},"ISSN":["2633-4402"],"issn-type":[{"value":"2633-4402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,10]]},"assertion":[{"value":"Indexed","URL":"https:\/\/openresearch.nihr.ac.uk\/articles\/3-7\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.3310\/nihropenres.14572.r29254, Eugene M. Dempsey, INFANT Research Centre, Department of Paediatrics and Child Health, University College Cork, Cork, County Cork, 25 May 2023, version 2, indexed","URL":"https:\/\/openresearch.nihr.ac.uk\/articles\/3-7\/v2#referee-response-29254","order":0,"name":"referee-response-29254","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.3310\/nihropenres.14572.r29255, Liam Mahoney, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, 22 May 2023, version 2, indexed","URL":"https:\/\/openresearch.nihr.ac.uk\/articles\/3-7\/v2#referee-response-29255","order":1,"name":"referee-response-29255","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This project is funded by the National Institute for Health Research (NIHR) under its [Research for Patient Benefit (RfPB) Programme (Grant Reference Number PB-PG-0211-24147 assigned to Prof Aladangady. Co-applicants are Dr Sinha A, Dr Banerjee J, Dr Chisholm P, Prof Morris JK and Dr Kempley S)]. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This open access work is licensed under the Open Government Licence v3.0.","order":0,"name":"copyright-info","label":"Copyright"}]}}