{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T06:13:39Z","timestamp":1793168019490,"version":"4.5.0"},"reference-count":19,"publisher":"National Institute for Health and Care Research","license":[{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009128","name":"Research for Patient Benefit Programme","doi-asserted-by":"publisher","award":["201019"],"award-info":[{"award-number":["201019"]}],"id":[{"id":"10.13039\/501100009128","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["openresearch.nihr.ac.uk"],"crossmark-restriction":false},"short-container-title":["NIHR Open Res"],"abstract":"<ns3:p>\n                    Postoperative bacterial endophthalmitis is an infection of the eye's internal tissues resulting from an intraocular procedure. The condition is uncommon but can cause severe and irreversible impairment of sight. Standard management involves administration of antibiotics with or without subsequent removal of the infected vitreous gel by vitrectomy surgery. Surgical intervention is typically reserved for infections that persist despite a period of medical management alone. We aim to determine whether outcomes can be improved by performing surgery without delay. To explore the feasibility of a definitive randomised controlled trial and to determine the number of participants required, we will conduct a multicentre feasibility trial. This trial will include 40 affected individuals, allocated randomly to either standard of care, being intravitreal antibiotic administration alone, or to early vitrectomy surgery in addition to antibiotic administration. We will determine the feasibility and size of a definitive trial by evaluating the participants and the outcomes for their sight. Research Ethics Committee approval (REC 20\/WM\/0264). Here we describe the trial protocol.\n                    <ns3:bold>Trial registration number:<\/ns3:bold>\n                    ClinicalTrials.gov NCT04522661\n                  <\/ns3:p>","DOI":"10.3310\/nihropenres.13469.1","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T10:15:15Z","timestamp":1695896115000},"page":"47","update-policy":"https:\/\/doi.org\/10.3310\/nihropenres.crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["A Randomised Controlled Trial of Early Vitrectomy and Intravitreal Antibiotics for Post-operative Exogenous Endophthalmitis (EVIAN study): study protocol for a feasibility trial"],"prefix":"10.3310","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1161-3956","authenticated-orcid":false,"given":"Mahiul Muhammed Khan","family":"Muqit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Pavesio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayley","family":"Boston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keerththika","family":"Sriharan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Pizzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Cobb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Spink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Bainbridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6221","published-online":{"date-parts":[[2023,9,28]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"88-93","DOI":"10.1016\/j.ajo.2016.02.028","article-title":"Postinjection endophthalmitis rates and characteristics following intravitreal bevacizumab, ranibizumab, and aflibercept.","volume":"165","author":"N Rayess","year":"2016","journal-title":"Am J Ophthalmol."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"107-111","DOI":"10.1016\/j.oftal.2016.09.006","article-title":"Endophthalmitis after intravitreal injections. 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The patient would have tap and injection as part of standard of care on initial presentation. They would then attend at the 48hours timepoint. At this 48 hour timepoint, if they are recruited and randomised, the vitrectomy surgery would be carried out after the 48 hour timepoint as per the protocol","URL":"https:\/\/openresearch.nihr.ac.uk\/articles\/3-47\/v1#referee-comment-3285","order":1,"name":"referee-comment-3285","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.3310\/nihropenres.14613.r30711, Gita Satpathy, Department of Microbiology, All India Institute of Medical Sciences, New Delhi, 24 Nov 2023, version 1, indexed","URL":"https:\/\/openresearch.nihr.ac.uk\/articles\/3-47\/v1#referee-response-30711","order":2,"name":"referee-response-30711","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This research is funded by the National Institute of Health Research - Research for Patient Benefit Programme (Project reference: 201019). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}