{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T02:01:40Z","timestamp":1772244100000,"version":"3.50.1"},"update-to":[{"DOI":"10.3310\/nihropenres.13786.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000}}],"reference-count":26,"publisher":"National Institute for Health and Care Research","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013374","name":"NIHR School for Primary Care Research","doi-asserted-by":"publisher","award":["NIHR203712"],"award-info":[{"award-number":["NIHR203712"]}],"id":[{"id":"10.13039\/501100013374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022244","name":"National Institute for Health Research Applied Research Collaboration West","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022244","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["openresearch.nihr.ac.uk"],"crossmark-restriction":false},"short-container-title":["NIHR Open Res"],"abstract":"<ns3:p>Introduction Motor Neurone Disease (MND) is a neurodegenerative condition affecting motor neurons in spinal cord and brainstem, leading to a reduced life expectancy. This study describes demographic trends in MND-associated mortality in the United States over a 20-year period. Methods Data was extracted from the Centers for Disease Control and Prevention Wide-Ranging OnLine Data for Epidemiologic Research underlying cause of death database. All death certificates from 1999\u20132020 with MND (G12.2) recorded as the cause of mortality were extracted. Annual MND-associated crude mortality rates (CMR) and age-adjusted mortality rates (AAMR) per 100,000 persons with 95% confidence intervals (CI) were calculated. Joinpont regression was used to calculate the annual trends in MND-associated mortality by calculating the annual percentage change. Results Between 1999 to 2020, there were a total 140,945 MND-associated deaths. Overall AAMR was 1.9 per 100,000 persons (95% CI 1.9-1.9). Male sex had a consistently higher AAMR (2.3 per 100,000 95% CI 2.3-2.3) than female sex (1.6 per 100,000 95% CI 1.5-1.6) across the study period. White patients had higher AAMR (2.1 per 100,000 95% CI 2.0-2.1) than Black\/African Americans (1.1 per 100,000 95% CI 1.0-1.1), American Indians\/Alaska Natives (0.8 per 100,000 95% CI 0.7-0.9), Asians\/Pacific Islanders (0.8 per 100,000 95% CI 0.7-0.9). The 3 US States with the highest AAMR were Vermont, followed by Minnesota and Maine. Conclusions There are a significant number of MND-associated deaths annually in the United States. The knowledge of these trends facilitates the design of appropriate services in areas of higher need, allowing for the introduction of pathways that support more suitable care and enhanced quality of life.<\/ns3:p>","DOI":"10.3310\/nihropenres.13786.2","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T01:05:09Z","timestamp":1763687109000},"page":"79","update-policy":"https:\/\/doi.org\/10.3310\/nihropenres.crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Demographic trends of motor neurone disease-associated mortality from 1999-2020 in the United States"],"prefix":"10.3310","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3306-5727","authenticated-orcid":false,"given":"Delaram","family":"Imantalab","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2315-0744","authenticated-orcid":false,"given":"Balamrit Singh","family":"Sokhal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sowmya","family":"Prasanna Kumar Menon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seema","family":"Kalra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6645-5751","authenticated-orcid":false,"given":"Sara","family":"Muller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2677-1028","authenticated-orcid":false,"given":"Christian","family":"Mallen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6221","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"840-6","DOI":"10.1177\/0269216313490436","article-title":"Place of death, and its relation with underlying cause of death, in Parkinson's Disease, Motor Neurone Disease, and Multiple Sclerosis: a population-based 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indexed","URL":"https:\/\/openresearch.nihr.ac.uk\/articles\/4-79\/v2#referee-response-38416","order":2,"name":"referee-response-38416","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This project is funded by the National Institute for Health and Care Research (NIHR) under the \u2018NIHR School for Primary Care Research\u2019 (Grant Reference Number NIHR203712) and Applied Research Collaboration West Midlands to CDM. SM is partly funded by the NIHR Applied Research Collaboration West Midlands. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}