{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:46:07Z","timestamp":1789987567116,"version":"4.0.1"},"reference-count":40,"publisher":"The Japanese Society for Medical Mycology","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nippon Ishinkin Gakkai Zasshi","Jpn. J. Med. Mycol.","Japanese Journal of Medical Mycology"],"published-print":{"date-parts":[[2010]]},"DOI":"10.3314\/jjmm.51.79","type":"journal-article","created":{"date-parts":[[2010,5,10]],"date-time":"2010-05-10T06:06:57Z","timestamp":1273471617000},"page":"79-86","source":"Crossref","is-referenced-by-count":4,"title":["Characterization of the Multi-drug Efflux Systems of Pathogenic Fungi Using Functional Hyperexpression in Saccharomyces cerevisiae"],"prefix":"10.3314","volume":"51","author":[{"given":"Masakazu","family":"Niimi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1842","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) \u65b0\u898b\u660c\u4e00: \u85ac\u5264\u8010\u6027\u907a\u4f1d\u5b50\u306e\u30d1\u30f3\u9175\u6bcd\u306b\u304a\u3051\u308b\u767a\u73fe\u3068\u6a5f\u80fd\u89e3\u6790. \u771f\u83cc\u8a8c 45: 63-69, 2004.","DOI":"10.1111\/j.1468-0149.2004.00327.x"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) \u65b0\u898b\u660c\u4e00, \u7530\u8fba\u516c\u4e00, \u548c\u7530\u4fca\u4e00, \u5c71\u5d0e\u4e9c\u5e0c\u5b50, \u4e0a\u539f\u81f3\u96c5, Niimi K, Lamping E, Holmes AR, Monk BC, Cannon RD: \u75c5\u539f\u771f\u83cc\u306eABC\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc -\u6a5f\u80fd\u89e3\u6790\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u77e5\u898b-. \u771f\u83cc\u8a8c 46: 249-260, 2005.","DOI":"10.3314\/jjmm.46.249"},{"issue":"1","key":"3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7883\/yoken.JJID.2005.1","volume":"58","author":"NIIMI M","year":"2005","ISSN":"https:\/\/id.crossref.org\/issn\/1344-6304","issn-type":"print"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Cannon RD, Lamping E, Holmes AR, Niimi K, Tanabe K, Niimi M, Monk BC: Candida albicans drug resistance another way to cope with stress. Microbiology 153: 3211-3217, 2007.","DOI":"10.1099\/mic.0.2007\/010405-0"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00051-08"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2009.10.007"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Niimi M, Firth NA, Cannon RD: Antifungal drug resistance of oral fungi. Odontology 98: 15-25, 2010.","DOI":"10.1007\/s10266-009-0118-3"},{"issue":"12","key":"8","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1128\/AAC.40.12.2835","volume":"40","year":"1996","ISSN":"https:\/\/id.crossref.org\/issn\/0066-4804","issn-type":"print"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Maebashi K, Niimi M, Kudoh M, Fischer FJ, Makimura K, Niimi K, Piper RJ, Uchida K, Arisawa M, Cannon RD, Yamaguchi H: Mechanisms of fluconazole resistance in Candida albicans isolates from Japanese AIDS patients. J Antimicrob Chemother 47: 527-536, 2001.","DOI":"10.1093\/jac\/47.5.527"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05357.x"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Holmes AR, Lin YH, Niimi K, Lamping E, Keniya M, Niimi M, Tanabe K, Monk BC, Cannon RD: ABC transporter Cdr1p contributes more than Cdr2p does to fluconazole efflux in fluconazole-resistant Candida albicans clinical isolates. Antimicrob Agents Chemother 52: 3851-3862, 2008.","DOI":"10.1128\/AAC.00463-08"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00029-06"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Niimi M, Kamiyama A, Tokunaga M: Respiration of medically important Candida species and Saccharomyces cerevisiae in relation to glucose effect. J Med Vet Mycol 26: 195-198, 1988.","DOI":"10.1080\/02681218880000271"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.4.1174-1183.2001"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Brun S, Aubry C, Lima O, Filmon R, Berges T, Chabasse D, Bouchara JP: Relationships between respiration and susceptibility to azole antifungals in Candida glabrata. Antimicrob Agents Chemother 47: 847-853, 2003.","DOI":"10.1128\/AAC.47.3.847-853.2003"},{"issue":"16","key":"16","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.1128\/JB.180.16.4177-4183.1998","volume":"180","author":"CROWLEY J H","year":"1998","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9193","issn-type":"print"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M407600200"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.9.2411-2418.2000"},{"issue":"4","key":"19","doi-asserted-by":"crossref","first-page":"306","DOI":"10.7883\/yoken.JJID.2009.306","volume":"62","author":"NAGI MINORU","year":"2009","ISSN":"https:\/\/id.crossref.org\/issn\/1344-6304","issn-type":"print"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Nakayama H, Tanabe K, Bard M, Hodgson W, Wu S, Takemori D, Aoyama T, Kumaraswami NS, Metzler L, Takano Y, Chibana H, Niimi M: The Candida glabrata putative sterol transporter gene CgAUS1 protects cells against azoles in the presence of serum. J Antimicrob Chemother 60: 1264-1272, 2007.","DOI":"10.1093\/jac\/dkm321"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Niimi M, Nagai Y, Niimi K, Wada S, Cannon RD, Uehara Y, Monk BC: Identification of two proteins induced by exposure of the pathogenic fungus Candida glabrata to fluconazole. J Chromatogr B 782: 245-252, 2002.","DOI":"10.1016\/S1570-0232(02)00668-2"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Lamping E, Ranchod A, Nakamura K, Tyndall JD, Niimi K, Holmes AR, Niimi M, Cannon RD: Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. Antimicrob Agents Chemother 53: 354-369, 2009.","DOI":"10.1128\/AAC.01095-08"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.12.3366-3374.2001"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.20.12612"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Carvajal E, van den Hazel HB, Cybularz-Kolaczkowska A, Balzi E, Goffeau A: Molecular and phenotypic characterization of yeast PDR1 mutants that show hyperactive transcription of various ABC multidrug transporter genes. Mol Gen Genet 256: 406-415, 1997.","DOI":"10.1007\/s004380050584"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00091-07"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207817200"},{"issue":"1","key":"28","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1074\/jbc.M408252200","volume":"280","author":"WADA S","year":"2005","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"key":"29","unstructured":"29) Niimi K, Monk BC, Hirai A, Hatakenaka K, Umeyama T, Lamping E, Maki K, Tanabe K, Kamimura T, Ikeda F, Uehara Y, Kano R, Hasegawa A, Cannon RD, Niimi M: Clinically significant micafungin resistance in Candida albicans involves modification of a glucan synthese catalytic subunit GSC1 (FKS1) allele followed by loss of heterozygosity. J Antimicrob Chemother 2010 (doi: 10.1093\/jac\/dkq073)."},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.10.110"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.4.1256-1271.2004"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Maesaki S, Marichal P, Hossain MA, Sanglard D, Vanden Bossche H, Kohno S: Synergic effects of tacrolimus and azole antifungal agents against azole-resistant Candida albicans strains. J Antimicrob Chemother 42: 747-753, 1998.","DOI":"10.1093\/jac\/42.6.747"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Dunkel N, Liu TT, Barker KS, Homayouni R, Morschhauser J, Rogers PD: A gain-of-function mutation in the transcription factor Upc2p causes upregulation of ergosterol biosynthesis genes and increased fluconazole resistance in a clinical Candida albicans isolate. Eukaryot Cell 7: 1180-1190, 2008.","DOI":"10.1128\/EC.00103-08"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.105.054767"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2008.06309.x"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1038\/nature06836"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1126\/science.1128242"},{"key":"38","unstructured":"38) O'Keeffe J, Kavanagh K: Adriamycin alters the expression of drug efflux pumps and confers amphotericin B tolerance in Candida albicans. Anticancer Res 24: 405-408, 2004."},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1126\/science.1159746"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Porro D, Branduardi P: Yeast cell factory: fishing for the best one or engineering it? Microb Cell Fact 8: 1-4, 2009.","DOI":"10.1186\/1475-2859-8-51"}],"container-title":["Nippon Ishinkin Gakkai Zasshi"],"original-title":[],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T18:48:33Z","timestamp":1740077313000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/jjmm\/51\/2\/51_2_79\/_article\/-char\/ja\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.3314\/jjmm.51.79","relation":{},"ISSN":["0916-4804","1882-0476"],"issn-type":[{"value":"0916-4804","type":"print"},{"value":"1882-0476","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}