{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T07:21:02Z","timestamp":1768720862674,"version":"3.49.0"},"reference-count":50,"publisher":"The Japanese Society for Medical Mycology","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Mycology Journal"],"published-print":{"date-parts":[[2017]]},"DOI":"10.3314\/mmj.17.011","type":"journal-article","created":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T22:12:53Z","timestamp":1504131173000},"page":"J83-J90","source":"Crossref","is-referenced-by-count":8,"title":["Recognition of <I>Cryptococcus neoformans<\/I> by Pattern Recognition Receptors and its Role in Host Defense to This Infection"],"prefix":"10.3314","volume":"58","author":[{"given":"Ko","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, Mycology and Immunology,Tohoku University Graduate School of Medicine"},{"name":"Virus Research Center, Clinical Research Division, Sendai Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyoshi","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Mycology and Immunology,Tohoku University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1842","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Perfect JR, Casadevall A: Cryptococcosis. Infect Dis Clin North Am 16: 837-874, 2002.","DOI":"10.1016\/S0891-5520(02)00036-3"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Lim TS, Murphy JW: Transfer of immunity to cryptococcosis by T-enriched splenic lymphocytes from Cryptococcus neoformans<\/I>-sensitized mice. Infect Immun 30: 5-11, 1980.","DOI":"10.1128\/IAI.30.1.5-11.1980"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Cunha BA: Central nervous system infections in the compromised host: a diagnostic approach. Infect Dis Clin North Am 15: 567-590, 2001.","DOI":"10.1016\/S0891-5520(05)70160-4"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Jarvis JN, Harrison TS: HIV-associated cryptococcal meningitis. AIDS 21: 2119-2129, 2007.","DOI":"10.1097\/QAD.0b013e3282a4a64d"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Feldmesser M, Tucker S, Casadevall A: Intracellular parasitism of macrophages by Cryptococcus neoformans<\/I>. Trends Microbiol 9: 273-278, 2001.","DOI":"10.1016\/S0966-842X(01)02035-2"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Koguchi Y, Kawakami K: Cryptococcal infection and Th1-Th2 cytokine balance. Int Rev Immunol 21: 423-438, 2002.","DOI":"10.1080\/08830180213274"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Arora S, Olszewski MA, Tsang TM, McDonald RA, Toews GB, Huffnagle GB: Effect of cytokine interplay on macrophage polarization during chronic pulmonary infection with Cryptococcus neoformans<\/I>. Infect Immun 79: 1915-1926, 2011.","DOI":"10.1128\/IAI.01270-10"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Tohyama M, Kawakami K, Futenma M, Saito A: Enhancing effect of oxygen radical scavengers on murine macrophage anticryptococcal activity through production of nitric oxide. Clin Exp Immunol 103: 436-441, 1996.","DOI":"10.1111\/j.1365-2249.1996.tb08299.x"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Hardison SE, Ravi S, Wozniak KL, Young ML, Olszewski MA, Wormley FL Jr: Pulmonary infection with an interferon-γ-producing Cryptococcus neoformans<\/I> strain results in classical macrophage activation and protection. Am J Pathol 176: 774-785, 2010.","DOI":"10.2353\/ajpath.2010.090634"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) McQuiston TJ, Williamson PR: Paradoxial roles of alveolar macrophages in the host response to Cryptococcus neoformans<\/I>. J Infect Chemother 18: 1-9, 2012.","DOI":"10.1007\/s10156-011-0306-2"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Arora S, Hernandez Y, Erb-Downward JR, McDonald RA, Toews GB, Huffnagle GB: Role of IFN-gamma in regulating T2 immunity and the development of alternatively activated macrophages during allergic bronchopulmonary mycosis. J Immunol 174: 6346-6356, 2005.","DOI":"10.4049\/jimmunol.174.10.6346"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Müller U, Stenzel W, Köhler G, Werner C, Polte T, Hansen G, Schütze N, Straubinger RK, Blessing M, McKenzie AN, Brombacher F, Alber G: IL-13 induces disease-promoting type 2 cytokines, alternatively activated macrophages and allergic inflammation during pulmonary infection of mice with Cryptococcus neoformans<\/I>. J Immunol 179: 5367-5377, 2007.","DOI":"10.4049\/jimmunol.179.8.5367"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Kumar H, Kawai T, Akira S: Pathogen recognition by the innate immune system. Int Rev Immunol 30: 16-34, 2011.","DOI":"10.3109\/08830185.2010.529976"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Netea MG, Ferwerda G, van der Graaf CA, Van der Meer JW, Kullberg BJ: Recognition of fungal pathogens by toll-like receptors. Curr Pharm Des 12: 4195-4201, 2006.","DOI":"10.2174\/138161206778743538"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Yauch LE, Mansour MK, Shoham S, Rottman JB, Levitz SM: Involvement of CD14, toll-like receptors 2 and 4, and MyD88 in the host response to the fungal pathogen Cryptococcus neoformans in vivo<\/I>. Infect Immun 72: 5373-5382, 2004.","DOI":"10.1128\/IAI.72.9.5373-5382.2004"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Biondo C, Midiri A, Messina L, Tomasello F, Garufi G, Catania MR, Bombaci M, Beninati C, Teti G, Mancuso G: MyD88 and TLR2, but not TLR4, are required for host defense against Cryptococcus neoformans<\/I>. Eur J Immunol 35: 870-878, 2005.","DOI":"10.1002\/eji.200425799"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Shoham S, Huang C, Chen JM, Golenbock DT, Levitz SM: Toll-like receptor 4 mediates intracellular signaling without TNF-alpha release in response to Cryptococcus neoformans<\/I> polysaccharide capsule. J Immunol 166: 4620-4626, 2001.","DOI":"10.4049\/jimmunol.166.7.4620"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Nakamura K, Miyagi K, Koguchi Y, et al: Limited contribution of Toll-like receptor 2 and 4 to the host response to a fungal infectious pathogen, Cryptococcus neoformans<\/I>. FEMS Immunol Med Microbiol 47: 148-154, 2006.","DOI":"10.1111\/j.1574-695X.2006.00078.x"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Nakamura K, Miyazato A, Xiao G, et al: Deoxynucleic acids from Cryptococcus neoformans<\/I> activate myeloid dendritic cells via a TLR9-dependent pathway. J Immunol 180: 4067-4074, 2008.","DOI":"10.4049\/jimmunol.180.6.4067"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Tanaka M, Ishii K, Nakamura Y, Miyazato A, Maki A, Abe Y, Miyasaka T, Yamamoto H, Akahori Y, Fue M, Takahashi Y, Kanno E, Maruyama R, Kawakami K: Toll-like receptor 9-dependent activation of bone marrow-derived dendritic cells by URA5 DNA from Cryptococcus neoformans<\/I>. Infect Immun 80: 778-786, 2012.","DOI":"10.1128\/IAI.05570-11"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Zhang Y, Wang F, Bhan U, Huffnagle GB, Toews GB, Standiford TJ, Olszewski MA: TLR9 signaling is required for generation of the adaptive immune protection in Cryptococcus neoformans<\/I>-infected lungs. Am J Pathol 177: 754-765, 2010.","DOI":"10.2353\/ajpath.2010.091104"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Inohara N, Chamaillard M, McDonald C, Núñez G: NOD-LRR proteins: role in host-microbial interactions and inflammatory disease. Annu Rev Biochem 74: 355-383, 2005.","DOI":"10.1146\/annurev.biochem.74.082803.133347"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Franchi L, Muñoz-Planillo R, Núñez G: Sensing and reacting to microbes through the inflammasomes. Nat Immunol 13: 325-332, 2012.","DOI":"10.1038\/ni.2231"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Hise AG, Tomalka J, Ganesan S, Patel K, Hall BA, Brown GD, Fitzgerald KA: An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans<\/I>. Cell Host Microbe 5: 487-497, 2009.","DOI":"10.1016\/j.chom.2009.05.002"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Saïd-Sadier N, Padilla E, Langsley G, Ojcius DM: Aspergillus fumigatus<\/I> stimulates the NLRP3 inflammasome through a pathway requiring ROS production and the Syk tyrosine kinase. PLoS One 5: e10008, 2010.","DOI":"10.1371\/journal.pone.0010008"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Lei G, Chen M, Li H, Niu JL, Wu S, Mao L, Lu A, Wang H, Chen W, Xu B, Leng Q, Xu C, Yang G, An L, Zhu LP, Meng G: Biofilm from a clinical strain of Cryptococcus neoformans<\/I> activates the NLRP3 inflammasome. Cell Res 23: 965-968, 2013.","DOI":"10.1038\/cr.2013.49"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Guo C, Chen M, Fa Z, Lu A, Fang W, Sun B, Chen C, Liao W, Meng G: Acapsular Cryptococcus neoformans<\/I> activates the NLRP3 inflammasome. Microbes Infect 16: 845-854, 2014.","DOI":"10.1016\/j.micinf.2014.08.013"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Zhang T, Kawakami K, Qureshi MH, Okamura H, Kurimoto M, Saito A: Interleukin-12 (IL-12) and IL-18 synergistically induce the fungicidal activity of murine peritoneal exudate cells against Cryptococcus neoformans<\/I> through production of gamma interferon by natural killer cells. Infect Immun 65: 3594-3599, 1997.","DOI":"10.1128\/IAI.65.9.3594-3599.1997"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Qureshi MH, Zhang T, Koguchi Y, Nakashima K, Okamura H, Kurimoto M, Kawakami K: Combined effects of IL-12 and IL-18 on the clinical course and local cytokine production in murine pulmonary infection with Cryptococcus neoformans<\/I>. Eur J Immunol 29: 643-649, 1999.","DOI":"10.1002\/(SICI)1521-4141(199902)29:02<643::AID-IMMU643>3.3.CO;2-5"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Kawakami K, Koguchi Y, Qureshi MH, Kinjo Y, Yara S, Miyazato A, Kurimoto M, Takeda K, Akira S, Saito A: Reduced host resistance and Th1 response to Cryptococcus neoformans<\/I> in interleukin-18 deficient mice. FEMS Microbiol Lett 186: 121-126, 2000.","DOI":"10.1111\/j.1574-6968.2000.tb09092.x"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Kawakami K, Koguchi Y, Qureshi MH, Miyazato A, Yara S, Kinjo Y, Iwakura Y, Takeda K, Akira S, Kurimoto M, Saito A: IL-18 contributes to host resistance against infection with Cryptococcus neoformans<\/I> in mice with defective IL-12 synthesis through induction of IFN-gamma production by NK cells. J Immunol 165: 941-947, 2000.","DOI":"10.4049\/jimmunol.165.2.941"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Kawakami K, Qureshi MH, Zhang T, Koguchi Y, Yara S, Takeda K, Akira S, Kurimoto M, Saito A: Involvement of endogenously synthesized interleukin (IL)-18 in the protective effects of IL-12 against pulmonary infection with Cryptococcus neoformans<\/I> in mice. FEMS Immunol Med Microbiol 27: 191-200, 2000.","DOI":"10.1111\/j.1574-695X.2000.tb01430.x"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Vautier S, MacCallum DM, Brown GD: C-type lectin receptors and cytokines in fungal immunity. Cytokine 58: 89-99, 2012.","DOI":"10.1016\/j.cyto.2011.08.031"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Gross O, Gewies A, Finger K, Schäfer M, Sparwasser T, Peschel C, Förster I, Ruland J: Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature 442: 651-656, 2006.","DOI":"10.1038\/nature04926"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Glocker EO, Hennigs A, Nabavi M, Schäffer AA, Woellner C, Salzer U, Pfeifer D, Veelken H, Warnatz K, Tahami F, Jamal S, Manguiat A, Rezaei N, Amirzargar AA, Plebani A, Hannesschläger N, Gross O, Ruland J, Grimbacher B: A homozygous CARD9 mutation in a family with susceptibility to fungal infections. N Engl J Med 361: 1727-1735, 2009.","DOI":"10.1056\/NEJMoa0810719"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Yamamoto H, Nakamura Y, Sato K, Takahashi Y, Nomura T, Miyasaka T, Ishii K, Hara H, Yamamoto N, Kanno E, Iwakura Y, Kawakami K: Defect of CARD9 leads to impaired accumulation of gamma interferon-producing memory phenotype T cells in lungs and increased susceptibility to pulmonary infection with Cryptococcus neoformans<\/I>. Infect Immun 82: 1606-1615, 2014.","DOI":"10.1128\/IAI.01089-13"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Brown GD, Gordon S: Fungal beta-glucans and mammalian immunity. Immunity 19: 311-315, 2003.","DOI":"10.1016\/S1074-7613(03)00233-4"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Saijo S, Fujikado N, Furuta T, Chung SH, Kotaki H, Seki K, Sudo K, Akira S, Adachi Y, Ohno N, Kinjo T, Nakamura K, Kawakami K, Iwakura Y: Dectin-1 is required for host defense against Pneumocystis carinii<\/I> but not against Candida albicans<\/I>. Nat Immunol 8: 39-46, 2007.","DOI":"10.1038\/ni1425"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Taylor PR, Tsoni SV, Willment JA, Dennehy KM, Rosas M, Findon H, Haynes K, Steele C, Botto M, Gordon S, Brown GD: Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nat Immunol 8: 31-38, 2007.","DOI":"10.1038\/ni1408"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Werner JL, Metz AE, Horn D, Schoeb TR, Hewitt MM, Schwiebert LM, Faro-Trindade I, Brown GD, Steele C: Requisite role for the dectin-1 beta-glucan receptor in pulmonary defense against Aspergillus fumigatus<\/I>. J Immunol 182: 4938-4946, 2009.","DOI":"10.4049\/jimmunol.0804250"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Plantinga TS, van der Velden WJ, Ferwerda B, van Spriel AB, Adema G, Feuth T, Donnelly JP, Brown GD, Kullberg BJ, Blijlevens NM, Netea MG: Early stop polymorphism in human DECTIN-1 is associated with increased candida<\/I> colonization in hematopoietic stem cell transplant recipients. Clin Infect Dis 49: 724-732, 2009.","DOI":"10.1086\/604714"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Sainz J, Lupiáñez CB, Segura-Catena J, Vazquez L, Ríos R, Oyonarte S, Hemminki K, Försti A, Jurado M: Dectin-1 and DC-SIGN polymorphisms associated with invasive pulmonary Aspergillosis infection. PLoS One 7: e32273, 2012.","DOI":"10.1371\/journal.pone.0032273"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Nakamura K, Kinjo T, Saijo S, Miyazato A, Adachi Y, Ohno N, Fujita J, Kaku M, Iwakura Y, Kawakami K: Dectin-1 is not required for the host defense to Cryptococcus neoformans<\/I>. Microbiol Immunol 51: 1115-1119, 2007.","DOI":"10.1111\/j.1348-0421.2007.tb04007.x"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Saijo S, Iwakura Y: Dectin-1 and Dectin-2 in innate immunity against fungi. Int Immunol 23: 467-472, 2011.","DOI":"10.1093\/intimm\/dxr046"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Saijo S, Ikeda S, Yamabe K, et al: Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans<\/I>. Immunity 32: 681-691, 2010.","DOI":"10.1016\/j.immuni.2010.05.001"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Loures FV, Röhm M, Lee CK, Santos E, Wang JP, Specht CA, Calich VL, Urban CF, Levitz SM: Recognition of Aspergillus fumigatus<\/I> hyphae by human plasmacytoid dendritic cells is mediated by dectin-2 and results in formation of extracellular traps. PLoS Pathogens 11: e1004643, 2015.","DOI":"10.1371\/journal.ppat.1004643"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47) Nakamura Y, Sato K, Yamamoto H, Matsumura K, Matsumoto I, Nomura T, Miyasaka T, Ishii K, Kanno E, Tachi M, Yamasaki S, Saijo S, Iwakura Y, Kawakami K: Dectin-2 deficiency promotes Th2 response and mucin production in the lungs after pulmonary infection with Cryptococcus neoformans<\/I>. Infect Immun 83: 671-681, 2015.","DOI":"10.1128\/IAI.02835-14"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48) Pietrella D, Corbucci C, Perito S, Bistoni G, Vecchiarelli A: Mannoproteins from Cryptococcus neoformans<\/I> promote dendritic cell maturation and activation. Infect Immun 73: 820-827, 2005.","DOI":"10.1128\/IAI.73.2.820-827.2005"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49) Dan JM, Kelly RM, Lee CK, Levitz SM: Role of the mannose receptor in a murine model of Cryptococcus neoformans<\/I> infection. Infect Immun 76: 2362-2367, 2008.","DOI":"10.1128\/IAI.00095-08"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50) Mansour MK, Latz E, Levitz SM: Cryptococcus neoformans<\/I> glycoantigens are captured by multiple lectin receptors and presented by dendritic cells. J Immunol 176: 3053-3061, 2006","DOI":"10.4049\/jimmunol.176.5.3053"}],"container-title":["Medical Mycology Journal"],"original-title":["\u30af\u30ea\u30d7\u30c8\u30b3\u30c3\u30af\u30b9\u611f\u67d3\u306b\u304a\u3051\u308b\u5bbf\u4e3b\u8a8d\u8b58\u3068\u751f\u4f53\u9632\u5fa1\u6a5f\u69cb"],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/mmj\/58\/3\/58_17.011\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T18:17:53Z","timestamp":1602872273000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/mmj\/58\/3\/58_17.011\/_article\/-char\/ja\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.3314\/mmj.17.011","relation":{},"ISSN":["2185-6486","2186-165X"],"issn-type":[{"value":"2185-6486","type":"print"},{"value":"2186-165X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}