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Yeast 31: 47-60, 2014.","DOI":"10.1002\/yea.2997"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Kwon-Chung KJ, Fraser JA, Doering TL, Wang Z, Janbon G, Idnurm A, Bahn YS: Cryptococcus neoformans<\/I> and Cryptococcus gattii<\/I>, the etiologic agents of cryptococcosis. Cold Spring Harb Perspect Med 4: a019760, 2014.","DOI":"10.1101\/cshperspect.a019760"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Park BJ, Wannemuehler KA, Marston BJ, Govender N, Pappas PG, Chiller TM. Estimation of the current global burden of cryptococcal meningitis among persons living with HIV\/AIDS. AIDS 23: 525-530, 2009.","DOI":"10.1097\/QAD.0b013e328322ffac"},{"key":"4","unstructured":"4) Perfect JR, Lang SD, Durack DT: Chronic cryptococcal meningitis: a new experimental model in rabbits. Am J Pathol 101: 177-194, 1980."},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Goldman D, Lee SC, Casadevall A: Pathogenesis of pulmonary Cryptococcus neoformans<\/I> infection in the rat. Infect Immun 62: 4755-4761, 1994.","DOI":"10.1128\/iai.62.11.4755-4761.1994"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Zaragoza O, Alvarez M, Telzak A, Rivera J, Casadevall A: The relative susceptibility of mouse strains to pulmonary Cryptococcus neoformans<\/I> infection is associated with pleiotropic differences in the immune response. Infect Immun 75: 2729-2739. 2007.","DOI":"10.1128\/IAI.00094-07"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Mylonakis E, Ausubel FM, Perfect JR, Heitman J, Calderwood SB: Killing of Caenorhabditis elegans<\/I> by Cryptococcus neoformans<\/I> as a model of yeast pathogenesis. Proc Natl Acad Sci U S A 99: 15675-15680, 2002.","DOI":"10.1073\/pnas.232568599"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Apidianakis Y, Rahme LG, Heitman J, Ausubel FM, Calderwood SB, Mylonakis E: Challenge of Drosophila melanogaster<\/I> with Cryptococcus neoformans<\/I> and role of the innate immune response. Eukaryot Cell 3: 413-419, 2004.","DOI":"10.1128\/EC.3.2.413-419.2004"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Mylonakis E, Moreno R, El Khoury JB, Idnurm A, Heitman J, Calderwood SB, Ausubel FM, Diener A: Galleria mellonella<\/I> as a model system to study Cryptococcus neoformans<\/I> pathogenesis. Infect Immun 73: 3842-3850, 2005.","DOI":"10.1128\/IAI.73.7.3842-3850.2005"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Matsumoto Y, Miyazaki S, Fukunaga DH, Shimizu K, Kawamoto S, Sekimizu K: Quantitative evaluation of cryptococcal pathogenesis and antifungal drugs using a silkworm infection model with Cryptococcus neoformans<\/I>. J App Microbiol 112: 138-146, 2012.","DOI":"10.1111\/j.1365-2672.2011.05186.x"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Matsumoto Y, Ishii M, Hayashi Y, Miyazaki S, Sugita T, Sumiya E, Sekimizu K: Diabetic silkworms for evaluation of therapeutically effective drugs against type II diabetes. Sci Rep 5: 10722, 2015.","DOI":"10.1038\/srep10722"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Matsumoto Y, Sumiya E, Sugita T, Sekimizu K: An invertebrate hyperglycemic model for the identification of anti-diabetic drugs. PLoS One 6: e18292, 2011.","DOI":"10.1371\/journal.pone.0018292"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Inagaki Y, Matsumoto Y, Kataoka K, Matsuhashi N, Sekimizu K: Evaluation of drug-induced tissue injury by measuring alanine aminotransferase (ALT) activity in silkworm hemolymph. BMC Pharmacol Toxicol 13: 13, 2012.","DOI":"10.1186\/2050-6511-13-13"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Kaito C, Akimitsu N, Watanabe H, Sekimizu K: Silkworm larvae as an animal model of bacterial infection pathogenic to humans. Microb Pathog 32: 183-190, 2002.","DOI":"10.1006\/mpat.2002.0494"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Kaito C, Kurokawa K, Matsumoto Y, Terao Y, Kawabata S, Hamada S, Sekimizu K: Silkworm pathogenic bacteria infection model for identification of novel virulence genes. Mol Microbiol 56: 934-944, 2005.","DOI":"10.1111\/j.1365-2958.2005.04596.x"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Hamamoto H, Urai M, Ishii K, et al. Lysocin E is a new antibiotic that targets menaquinone in the bacterial membrane. Nat Chem Biol 11: 127-133, 2015.","DOI":"10.1038\/nchembio.1710"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Kaito C, Usui K, Kyuma T, Sekimizu K: Isolation of mammalian pathogenic bacteria using silkworms. Drug Discov Ther 5: 66-70, 2011.","DOI":"10.5582\/ddt.2011.v5.2.66"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Ishii M, Matsumoto Y, Sekimizu K: Usefulness of silkworm as a model animal for understanding the molecular mechanisms of fungal pathogenicity. Drug Discov Ther 9: 234-237, 2015.","DOI":"10.5582\/ddt.2015.01052"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Hanaoka N, Takano Y, Shibuya K, Fugo H, Uehara Y, Niimi M: Identification of the putative protein phosphatase gene PTC1<\/I> as a virulence-related gene using a silkworm model of Candida albicans<\/I> infection. Eukaryot Cell 7: 1640-1648, 2008.","DOI":"10.1128\/EC.00129-08"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Ueno K, Matsumoto Y, Uno J, Sasamoto K, Sekimizu K, Kinjo Y, Chibana H: Intestinal resident yeast Candida glabrata<\/I> requires Cyb2p<\/I>-mediated lactate assimilation to adapt in mouse intestine. PLoS One 6: e24759, 2011.","DOI":"10.1371\/journal.pone.0024759"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Hamamoto H, Tonoike A, Narushima K, Horie R, Sekimizu K: Silkworm as a model animal to evaluate drug candidate toxicity and metabolism. Comp Biochem Physiol C Toxicol Pharmacol 149: 334-339, 2009.","DOI":"10.1016\/j.cbpc.2008.08.008"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Usui K, Nishida S, Sugita T, Ueki T, Matsumoto Y, Okumura H, Sekimizu K: Acute oral toxicity test of chemical compounds in silkworms. Drug Discov Ther 10: 57-61, 2016.","DOI":"10.5582\/ddt.2016.01025"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Hamamoto H, Kurokawa K, Kaito C, Kamura K, Manitra Razanajatovo I, Kusuhara H, Santa T, Sekimizu K: Quantitative evaluation of the therapeutic effects of antibiotics using silkworms infected with human pathogenic microorganisms. Antimicrob Agents Chemother 48: 774-779, 2004.","DOI":"10.1128\/AAC.48.3.774-779.2004"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Kozubowski L, Heitman J: Septins enforce morphogenetic events during sexual reproduction and contribute to virulence of Cryptococcus neoformans<\/I>. Mol Microbiol 75: 658-675. 2010.","DOI":"10.1111\/j.1365-2958.2009.06983.x"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Lev S, Crossett B, Cha SY, Desmarini D, Li C, Chayakulkeeree M, Wilson CF, Williamson PR, Sorrell TC, Djordjevic JT: Identification of Aph1, a phosphate-regulated, secreted, and vacuolar acid phosphatase in Cryptococcus neoformans<\/I>. MBio 5: e01649-14, 2014.","DOI":"10.1128\/mBio.01649-14"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Chabrier-Roselló Y, Gerik KJ, Koselny K, DiDone L, Lodge JK, Krysan DJ: Cryptococcus neoformans<\/I> phosphoinositide-dependent kinase 1 (PDK1) ortholog is required for stress tolerance and survival in murine phagocytes. Eukaryot Cell 12: 12-22, 2013.","DOI":"10.1128\/EC.00235-12"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Binder U, Maurer E, Lass-Flörl C: Galleria mellonella: An invertebrate model to study pathogenicity in correctly defined fungal species. Fungal Biology 120: 288-295, 2016.","DOI":"10.1016\/j.funbio.2015.06.002"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Vu K, Gelli A: Astemizole and an analogue promote fungicidal activity of fluconazole against Cryptococcus neoformans<\/I> var. grubii<\/I> and Cryptococcus gattii<\/I>. Med Mycol 48: 255-262, 2010.","DOI":"10.3109\/13693780903081968"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) García-Rodas R, Casadevall A, Rodíguez-Tudela JL, Cuenca-Estrella M, Zaragoza O: Cryptococcus neoformans<\/I> capsular enlargement and cellular gigantism during Galleria mellonella<\/I> infection. PLoS One 6: e24485, 2011.","DOI":"10.1371\/journal.pone.0024485"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Desalermos A, Tan X, Rajamuthiah R, Arvanitis M, Wang Y, Li D, Kourkoumpetis TK, Fuchs BB, Mylonakis E: A multi-host approach for the systematic analysis of virulence factors in Cryptococcus neoformans<\/I>. J Infect Dis 211: 298-305, 2015.","DOI":"10.1093\/infdis\/jiu441"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Matthews KA, Kaufman TC, Gelbart WM: Research resources for Drosophila<\/I>: the expanding universe. Nat Rev Genet 6: 179-193, 2005.","DOI":"10.1038\/nrg1554"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Venken KJ, Bellen HJ: Emerging technologies for gene manipulation in Drosophila melanogaster<\/I>. Nature Reviews Genetics 6: 167-178, 2005.","DOI":"10.1038\/nrg1553"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Kaletta T, Hengartner MO: Finding function in novel targets: C. elegans<\/I> as a model organism. Nat Rev Drug Discov 5: 387-398, 2006.","DOI":"10.1038\/nrd2031"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Kerry S, TeKippe M, Gaddis NC, Aballay A: GATA transcription factor required for immunity to bacterial and fungal pathogens. PLoS One 1: e77, 2006.","DOI":"10.1371\/journal.pone.0000077"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) TeKippe M, Aballay A: C. elegans<\/I> germline-deficient mutants respond to pathogen infection using shared and distinct mechanisms. PLoS One 5: e11777, 2010.","DOI":"10.1371\/journal.pone.0011777"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Means TK, Mylonakis E, Tampakakis E, Colvin RA, Seung E, Puckett L, Tai MF, Stewart CR, Pukkila-Worley R, Hickman SE, Moore KJ, Calderwood SB, Hacohen N, Luster AD, El Khoury J: Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36. J Exp Med 206: 637-653, 2009.","DOI":"10.1084\/jem.20082109"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Morrow CA, Valkov E, Stamp A, Chow EW, Lee IR, Wronski A, Williams SJ, Hill JM, Djordjevic JT, Kappler U, Kobe B, Fraser JA: De novo GTP biosynthesis is critical for virulence of the fungal pathogen Cryptococcus neoformans<\/I>. PLoS Pathog 8: e1002957, 2012.","DOI":"10.1371\/journal.ppat.1002957"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Cordeiro Rde A, Evangelista AJ, Serpa R, Marques FJ, de Melo CV, de Oliveira JS, Franco Jda S, de Alencar LP, Bandeira Tde J, Brilhante RS, Sidrim JJ, Rocha MF: Inhibition of heat-shock protein 90 enhances the susceptibility to antifungals and reduces the virulence of Cryptococcus neoformans\/C. gattii<\/I> species complex. Microbiology 162: 309-317, 2016.","DOI":"10.1099\/mic.0.000222"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Matsumoto Y, Ishii M, Ishii K, Miyaguchi W, Horie R, Inagaki Y, Hamamoto H, Tatematsu K, Uchino K, Tamura T, Sezutsu H, Sekimizu K: Transgenic silkworms expressing human insulin receptors for evaluation of therapeutically active insulin receptor agonists. Biochem Biophys Res Commun 455: 159-164, 2014.","DOI":"10.1016\/j.bbrc.2014.10.143"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Inagaki Y, Matsumoto Y, Ishii M, Uchino K, Sezutsu H, Sekimizu K: Fluorescence imaging for a noninvasive in vivo<\/I> toxicity-test using a transgenic silkworm expressing green fluorescent protein. Sci Rep 5: 11180, 2015.","DOI":"10.1038\/srep11180"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Imamura M, Nakai J, Inoue S, Quan GX, Kanda T, Tamura T: Targeted gene expression using the GAL4\/UAS system in the silkworm Bombyx mori<\/I>. Genetics 165: 1329-1340, 2003.","DOI":"10.1093\/genetics\/165.3.1329"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Ishii M, Matsumoto Y, Nakamura I, Sekimizu K: Silkworm fungal infection model for identification of virulence genes in pathogenic fungus and screening of novel antifungal drugs. Drug Discov Ther 11: 1-5, 2017.","DOI":"10.5582\/ddt.2016.01080"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) McClelland EE, Hobbs LM, Rivera J, Casadevall A, Potts WK, Smith JM, Ory JJ: The role of host gender in the pathogenesis of Cryptococcus neoformans<\/I> infections. PLoS One 8: e63632, 2013.","DOI":"10.1371\/journal.pone.0063632"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Ishii M, Matsumoto Y, Sekimizu K: Usefulness of silkworm as a host animal for understanding pathogenicity of Cryptococcus neoformans<\/I>. 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