{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T15:04:18Z","timestamp":1767625458304},"reference-count":31,"publisher":"The Japanese Society for Medical Mycology","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Mycology Journal"],"published-print":{"date-parts":[[2018]]},"DOI":"10.3314\/mmj.18-00007","type":"journal-article","created":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T22:43:13Z","timestamp":1543531393000},"page":"E63-E70","source":"Crossref","is-referenced-by-count":9,"title":["Heterogeneity in Pathogenicity-related Properties and Stress Tolerance in &lt;i&gt;Aspergillus fumigatus&lt;\/i&gt; Clinical Isolates"],"prefix":"10.3314","volume":"59","author":[{"given":"Daisuke","family":"Hagiwara","sequence":"first","affiliation":[{"name":"Medical Mycology Research Center, Chiba University"},{"name":"Faculty of Life and Environmental Sciences, University of Tsukuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Medical Mycology Research Center, Chiba University"},{"name":"Molecular Chirality Research Center, Chiba University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Takagi","sequence":"additional","affiliation":[{"name":"Graduate School of Science and Technology, Nara Institute of Science and Technology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Medical Mycology Research Center, Chiba University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiko","family":"Kamei","sequence":"additional","affiliation":[{"name":"Medical Mycology Research Center, Chiba University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1842","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Denning DW: Chronic forms of pulmonary aspergillosis. Clin Microbiol Infect 7(Suppl 2): S25-S31, 2001.","DOI":"10.1111\/j.1469-0691.2001.tb00006.x"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) M&uuml;ller FM, Seidler M, Beauvais A: <i>Aspergillus fumigatus<\/i> biofilms in the clinical setting. Med Mycol 49 (Suppl 1): S96-S100, 2011.","DOI":"10.3109\/13693786.2010.502190"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Takahashi-Nakaguchi A, Muraosa Y, Hagiwara D, Sakai K, Toyotome T, Watanabe A, Kawamoto S, Kamei K, Gonoi T, Takahashi H: Genome sequence comparison of <i>Aspergillus fumigatus<\/i> strains isolated from patients with pulmonary aspergilloma and chronic necrotizing pulmonary aspergillosis. Med Mycol 53: 353-360, 2015.","DOI":"10.1093\/mmy\/myv003"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Reeves EP, Messina CG, Doyle S, Kavanagh K: Correlation between gliotoxin production and virulence of <i>Aspergillus fumigatus<\/i> in <i>Galleria mellonella<\/i>. Mycopathologia 158: 73-79. 2004.","DOI":"10.1023\/B:MYCO.0000038434.55764.16"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Scharf DH, Heinekamp T, Remme N, Hortschansky P, Brakhage AA, Hertweck C: Biosynthesis and function of gliotoxin in <i>Aspergillus fumigatus<\/i>. Appl Microbiol Biotechnol 93: 467-472, 2012.","DOI":"10.1007\/s00253-011-3689-1"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) McDonagh A, Fedorova ND, Crabtree J, Yu Y, Kim S, Chen D, Loss O, Cairns T, Goldman G, Armstrong-James D, Haynes K, Haas H, Schrettl M, May G, Nierman WC, Bignell E: Sub-telomere directed gene expression during initiation of invasive aspergillosis. PLoS Pathog 4: e1000154, 2008.","DOI":"10.1371\/journal.ppat.1000154"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Lewis RE, Wiederhold NP, Chi J, Han XY, Komanduri KV, Kontoyiannis DP, Prince RA: Detection of gliotoxin in experimental and human aspergillosis. Infect Immun 7: 635-637, 2005.","DOI":"10.1128\/IAI.73.1.635-637.2005"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Spikes S, Xu R, Nguyen CK, Chamilos G, Kontoyiannis DP, Jacobson RH, Ejzykowicz DE, Chiang LY, Filler SG, May GS: Gliotoxin production in <i>Aspergillus fumigatus<\/i> contributes to host-specific differences in virulence. J Infect Dis 197: 479-486, 2008.","DOI":"10.1086\/525044"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Kothary MH, Chase T Jr, Macmillan JD: Correlation of elastase production by some strains of <i>Aspergillus fumigatus<\/i> with ability to cause pulmonary invasive aspergillosis in mice. Infect Immun 43: 320-325, 1984.","DOI":"10.1128\/IAI.43.1.320-325.1984"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Brown NA, Goldman GH: The contribution of <i>Aspergillus fumigatus<\/i> stress responses to virulence and antifungal resistance. J Microbiol 54: 243-253, 2016.","DOI":"10.1007\/s12275-016-5510-4"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Kowalski CH, Beattie SR, Fuller KK, McGurk EA, Tang YW, Hohl TM, Obar JJ, Cramer RA Jr: Heterogeneity among Isolates reveals that fitness in low oxygen correlates with <i>Aspergillus fumigatus<\/i> virulence. MBio 7: e01515-16, 2016.","DOI":"10.1128\/mBio.01515-16"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Grahl N, Puttikamonkul S, Macdonald JM, Gamcsik MP, Ngo LY, Hohl TM, Cramer RA: <i>In vivo<\/i> hypoxia and a fungal alcohol dehydrogenase influence the pathogenesis of invasive pulmonary aspergillosis. PLoS Pathog 7: e1002145, 2011.","DOI":"10.1371\/journal.ppat.1002145"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Shepardson KM, Ngo LY, Aimanianda V, Latg&eacute; JP, Barker BM, Blosser SJ, Iwakura Y, Hohl TM, Cramer RA: Hypoxia enhances innate immune activation to <i>Aspergillus fumigatus<\/i> through cell wall modulation. Microbes Infect 15: 259-269, 2013.","DOI":"10.1016\/j.micinf.2012.11.010"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Grahl N, Shepardson KM, Chung D, Cramer RA: Hypoxia and fungal pathogenesis: to air or not to air? Eukaryot Cell 11: 560-570, 2012.","DOI":"10.1128\/EC.00031-12"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Schrettl M, Haas H: Iron homeostasis\u2015Achilles&apos; heel of <i>Aspergillus fumigatus<\/i>? Curr Opin Microbiol 14: 400-405, 2011.","DOI":"10.1016\/j.mib.2011.06.002"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Schrettl M, Bignell E, Kragl C, Joechl C, Rogers T, Arst HN Jr, Haynes K, Haas H: Siderophore biosynthesis but not reductive iron assimilation is essential for <i>Aspergillus fumigatus<\/i> virulence. J Exp Med 200: 1213-1219, 2004.","DOI":"10.1084\/jem.20041242"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Brown AJ, Haynes K, Quinn J: Nitrosative and oxidative stress responses in fungal pathogenicity. Curr Opin Microbiol 12: 384-391, 2009.","DOI":"10.1016\/j.mib.2009.06.007"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Blanco JL, Hontecillas R, Bouza E, Blanco I, Pelaez T, Mu&ntilde;oz P, Perez Molina J, Garcia ME: Correlation between the elastase activity index and invasiveness of clinical isolates of <i>Aspergillus fumigatus<\/i>. J Clin Microbiol 40: 1811-1813, 2002.","DOI":"10.1128\/JCM.40.5.1811-1813.2002"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Hagiwara D, Takahashi H, Watanabe A, Takahashi-Nakaguchi A, Kawamoto S, Kamei K, Gonoi T: Whole-genome comparison of <i>Aspergillus fumigatus<\/i> strains serially isolated from patients with aspergillosis. J Clin Microbiol 52: 4202-4209, 2014.","DOI":"10.1128\/JCM.01105-14"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Saldanha AJ: Java Treeview\u2015extensible visualization of microarray data. Bioinformatics 20: 3246-3248, 2004.","DOI":"10.1093\/bioinformatics\/bth349"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Hagiwara D, Sakamoto K, Abe K, Gomi K: Signaling pathways for stress responses and adaptation in <i>Aspergillus<\/i> species: stress biology in the post-genomic era. Biosci Biotechnol Biochem 80: 1667-1680, 2016.","DOI":"10.1080\/09168451.2016.1162085"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Bultman KM, Kowalski CH, Cramer RA: <i>Aspergillus fumigatus<\/i> virulence through the lens of transcription factors. Med Mycol 55: 24-38, 2017.","DOI":"10.1093\/mmy\/myw120"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Zanni PCMD, Bonfim-Mendon&ccedil;a PS, Negri M, Nakamura SS, Donatti L, Svidzinski TIE, Consolaro MEL: Virulence factors and genetic variability of vaginal <i>Candida albicans<\/i> isolates from HIV-infected women in the post-highly active antiretroviral era. Rev Inst Med Trop Sao Paulo 59: e44, 2017.","DOI":"10.1590\/s1678-9946201759044"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Sherry L, Rajendran R, Lappin DF, Borghi E, Perdoni F, Falleni M, Tosi D, Smith K, Williams C, Jones B, Nile CJ, Ramage G: Biofilms formed by <i>Candida albicans<\/i> bloodstream isolates display phenotypic and transcriptional heterogeneity that are associated with resistance and pathogenicity. BMC Microbiol 14: 182, 2014.","DOI":"10.1186\/1471-2180-14-182"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Billmyre RB, Clancey SA, Heitman J: Natural mismatch repair mutations mediate phenotypic diversity and drug resistance in <i>Cryptococcus deuterogattii<\/i>. Elife 6: e28802, 2017.","DOI":"10.7554\/eLife.28802"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Fuller KK, Cramer RA, Zegans ME, Dunlap JC, Loros JJ: <i>Aspergillus fumigatus<\/i> photobiology illuminates the marked heterogeneity between Isolates. MBio 7: e01517-16, 2016.","DOI":"10.1128\/mBio.01517-16"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Hagiwara D, Sakai K, Suzuki S, Umemura M, Nogawa T, Kato N, Osada H, Watanabe A, Kawamoto S, Gonoi T, Kamei K: Temperature during conidiation affects stress tolerance, pigmentation, and trypacidin accumulation in the conidia of the airborne pathogen <i>Aspergillus fumigatus<\/i>. PLoS One 12: e0177050, 2017.","DOI":"10.1371\/journal.pone.0177050"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Takahashi-Nakaguchi A, Sakai K, Takahashi H, Hagiwara D, Toyotome T, Chibana H, Watanabe A, Yaguchi T, Yamaguchi M, Kamei K, Gonoi T: <i>Aspergillus fumigatus<\/i> adhesion factors in dormant conidia revealed through comparative phenotypic and transcriptomic analyses. Cell Microbiol 20: e12802, 2018.","DOI":"10.1111\/cmi.12802"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Lind AL, Wisecaver JH, Lameiras C, Wiemann P, Palmer JM, Keller NP, Rodrigues F, Goldman GH, Rokas A: Drivers of genetic diversity in secondary metabolic gene clusters within a fungal species. PLoS Biol 15: e2003583, 2017.","DOI":"10.1371\/journal.pbio.2003583"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Ashu EE, Hagen F, Chowdhary A, Meis JF, Xu J: Global population genetic analysis of <i>Aspergillus fumigatus<\/i>. mSphere 2: e00019-17, 2017.","DOI":"10.1128\/mSphere.00019-17"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Garc&iacute;a ME, Caballero J, Blanco I, Cruzado M, Costas E, Blanco JL: Changes in the elastase activity and colonization ability of <i>Aspergillus fumigatus<\/i> after successive inoculations in mice. Rev Iberoam Micol 23: 221-223, 2006.","DOI":"10.1016\/S1130-1406(06)70048-1"}],"container-title":["Medical Mycology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/mmj\/59\/4\/59_18-00007\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T10:20:49Z","timestamp":1605522049000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/mmj\/59\/4\/59_18-00007\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.3314\/mmj.18-00007","relation":{},"ISSN":["2185-6486","2186-165X"],"issn-type":[{"value":"2185-6486","type":"print"},{"value":"2186-165X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}