{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:34:11Z","timestamp":1759937651140},"reference-count":60,"publisher":"The Japanese Society for Medical Mycology","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Mycology Journal"],"published-print":{"date-parts":[[2024,7,31]]},"DOI":"10.3314\/mmj.24.006","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T22:15:18Z","timestamp":1725056118000},"page":"67-74","source":"Crossref","is-referenced-by-count":3,"title":["Basic Research on <i>Candida<\/i> Species"],"prefix":"10.3314","volume":"65","author":[{"given":"Masahiro","family":"Abe","sequence":"first","affiliation":[{"name":"Department of Fungal Infection, National Institute of Infectious Diseases"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Kinjo","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, The Jikei University School of Medicine"},{"name":"Jikei Center for Biofilm Science and Technology, The Jikei University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuro","family":"Koshikawa","sequence":"additional","affiliation":[{"name":"Department of Fungal Infection, National Institute of Infectious Diseases"},{"name":"Department of Microbiology, St. Marianna University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitsugu","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Fungal Infection, National Institute of Infectious Diseases"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1842","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Wisplinghoff H, Bischoff T, Tallent SM, Seifert H, Wenzel RP, Edmond MB: Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis 39: 309–17, 2004.","DOI":"10.1086\/421946"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Zeise KD, Woods RJ, Huffnagle GB: Interplay between Candida albicans<\/i> and lactic acid bacteria in the gastrointestinal tract: impact on colonization resistance, microbial carriage, opportunistic infection, and host immunity. Clin Microbiol Rev 34: e0032320, 2021.","DOI":"10.1128\/CMR.00323-20"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Sobel JD: Vulvovaginal candidosis. Lancet 369: 1961–71, 2007.","DOI":"10.1016\/S0140-6736(07)60917-9"},{"key":"4","unstructured":"4) Marr KA: Invasive Candida<\/i> infections: the changing epidemiology. Oncology (Williston Park) 18: 9–14, 2004."},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Bouza E, Mu\u00f1oz P: Epidemiology of candidemia in intensive care units. Int J Antimicrob Agents 32 (Suppl 2): S87–91, 2008.","DOI":"10.1016\/S0924-8579(08)70006-2"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Swidergall M, Filler SG: Oropharyngeal candidiasis: fungal invasion and epithelial cell responses. PLoS Pathog 13: e1006056, 2017.","DOI":"10.1371\/journal.ppat.1006056"},{"key":"7","unstructured":"7) Verfaillie C, Weisdorf D, Haake R, Hostetter M, Ramsay NK, McGlave P: Candida<\/i> infections in bone marrow transplant recipients. Bone Marrow Transplant 8: 177–84, 1991."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Falagas ME, Apostolou KE, Pappas VD: Attributable mortality of candidemia: a systematic review of matched cohort and case-control studies. Eur J Clin Microbiol Infect Dis 25: 419–25, 2006.","DOI":"10.1007\/s10096-006-0159-2"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Donahue SP, Greven CM, Zuravleff JJ, Eller AW, Nguyen MH, Peacock JE Jr, et al: Intraocular candidiasis in patients with candidemia: clinical implications derived from a prospective multicenter study. Ophthalmology 101: 1302–9, 1994.","DOI":"10.1016\/S0161-6420(94)31175-4"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Oude Lashof AM, Rothova A, Sobel JD, Ruhnke M, Pappas PG, Viscoli C, et al: Ocular manifestations of candidemia. Clin Infect Dis 53: 262–8, 2011.","DOI":"10.1093\/cid\/cir355"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Durand ML: Endophthalmitis. Clin Microbiol Infect 19: 227–34, 2013.","DOI":"10.1111\/1469-0691.12118"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Phongkhun K, Pothikamjorn T, Srisurapanont K, Manothummetha K, Sanguankeo A, Thongkam A, et al: Prevalence of ocular candidiasis and Candida<\/i> endophthalmitis in patients with candidemia: a systematic review and meta-analysis. Clin Infect Dis 76: 1738–49, 2023.","DOI":"10.1093\/cid\/ciad064"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Sakai D, Matsumiya W, Kusuhara S, Nakamura M: Factors associated with the development of ocular candidiasis and ocular prognosis with echinocandin therapy for candidemia. J Ophthalmic Inflamm Infect 11: 17, 2021.","DOI":"10.1186\/s12348-021-00248-0"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Ueda T, Takesue Y, Tokimatsu I, Miyazaki T, Nakada-Motokawa N, Nagao M, et al: The incidence of endophthalmitis or macular involvement and the necessity of a routine ophthalmic examination in patients with candidemia. PLoS One 14: e0216956, 2019.","DOI":"10.1371\/journal.pone.0216956"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Sano T, Sasaki H, Maki Y, Nagaoka R, Hamamoto T, Sugaoka S, et al: Ocular candidiasis in a tertiary hospital in Japan: a 10-year single-center retrospective study. J Infect Chemother 29: 1081–7, 2023.","DOI":"10.1016\/j.jiac.2023.06.019"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Son HJ, Kim MJ, Lee S, Choi S, Jung KH, Jung J, et al: Risk factors and outcomes of patients with ocular involvement of candidemia. PLoS One 14: e0222356, 2019.","DOI":"10.1371\/journal.pone.0222356"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Pappas PG, Kauffman CA, Andes DR, Clancy CJ, Marr KA, Ostrosky-Zeichner L, et al: Clinical practice guideline for the management of candidiasis: 2016 update by the Infectious Diseases Society of America. Clin Infect Dis 62: e1–50, 2016.","DOI":"10.1093\/cid\/civ933"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Abe M, Kinjo Y, Ueno K, Takatsuka S, Nakamura S, Ogura S, et al: Differences in ocular complications between Candida albicans<\/i> and non-albicans Candida<\/i> infection analyzed by epidemiology and a mouse ocular candidiasis model. Front Microbiol 9: 2477, 2018.","DOI":"10.3389\/fmicb.2018.02477"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Abe M, Nakamura S, Kinjo Y, Masuyama Y, Mitsuyama J, Kaku M, et al: Efficacy of T-2307, a novel arylamidine, against ocular complications of disseminated candidiasis in mice. J Antimicrob Chemother 74: 1327–32, 2019.","DOI":"10.1093\/jac\/dkz020"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Fridkin SK, Jarvis WR: Epidemiology of nosocomial fungal infections. Clin Microbiol Rev 9: 499–511, 1996.","DOI":"10.1128\/CMR.9.4.499"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Ala-Houhala M, Anttila VJ: Characteristics of late recurrent candidemia in adult patients. Mycoses 64: 503–10, 2021.","DOI":"10.1111\/myc.13236"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Nucci M, Anaissie E: Revisiting the source of candidemia: skin or gut? Clin Infect Dis 33: 1959–67, 2001.","DOI":"10.1086\/323759"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Pan CH, Lo HJ, Yan JY, Hsiao YJ, Hsueh JW, Lin DW, et al:\u00a0Candida albicans<\/i>\u00a0colonizes and disseminates to the gastrointestinal tract in the presence of the microbiota in a severe combined immunodeficient mouse model. Front Microbiol 11: 619878, 2021.","DOI":"10.3389\/fmicb.2020.619878"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Cole GT, Halawa AA, Anaissie EJ: The role of the gastrointestinal tract in hematogenous candidiasis: from the laboratory to the bedside. Clin Infect Dis 22 (Suppl 2): S73–88, 1996.","DOI":"10.1093\/clinids\/22.Supplement_2.S73"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Ekenna O, Sherertz RJ: Factors affecting colonization and dissemination of Candida albicans<\/i> from the gastrointestinal tract of mice. Infect Immun 55: 1558–63, 1987.","DOI":"10.1128\/iai.55.7.1558-1563.1987"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) de Repentigny L, Phaneuf M, Mathieu LG: Gastrointestinal colonization and systemic dissemination by Candida albicans<\/i> and Candida tropicalis<\/i> in intact and immunocompromised mice. Infect Immun 60: 4907–14, 1992.","DOI":"10.1128\/iai.60.11.4907-4914.1992"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Hirayama T, Miyazaki T, Ito Y, Wakayama M, Shibuya K, Yamashita K, et al: Virulence assessment of six major pathogenic Candida<\/i> species in the mouse model of invasive candidiasis caused by fungal translocation. Sci Rep 10: 3814, 2020.","DOI":"10.1038\/s41598-020-60792-y"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Satoh K, Makimura K, Hasumi Y, Nishiyama Y, Uchida K, Yamaguchi H: Candida auris<\/i> sp. nov., a novel ascomycetous yeast isolated from the external ear canal of an inpatient in a Japanese hospital. Microbiol Immunol 53: 41–4, 2009.","DOI":"10.1111\/j.1348-0421.2008.00083.x"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Chowdhary A, Sharma C, Duggal S, Agarwal K, Prakash A, Singh PK, et al: New clonal strain of Candida auris<\/i>, Delhi, India. Emerg Infect Dis 19: 1670–3, 2013.","DOI":"10.3201\/eid1910.130393"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Lockhart SR, Etienne KA, Vallabhaneni S, Farooqi J, Chowdhary A, Govender NP, et al: Simultaneous emergence of multidrug-resistant Candida auris<\/i> on 3 continents confirmed by whole-genome sequencing and epidemiological analyses. Clin Infect Dis 64: 134–40, 2017.","DOI":"10.1093\/cid\/ciw691"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Magobo RE, Corcoran C, Seetharam S, Govender NP: Candida auris<\/i>-associated candidemia, South Africa. Emerg Infect Dis 20: 1250–1, 2014.","DOI":"10.3201\/eid2007.131765"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Simon SP, Li R, Silver M, Andrade J, Tharian B, Fu L, et al: Comparative outcomes of Candida auris<\/i> bloodstream infections: a multicenter retrospective case-control study. Clin Infect Dis 76: e1436–43, 2023.","DOI":"10.1093\/cid\/ciac735"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Welsh RM, Bentz ML, Shams A, Houston H, Lyons A, Rose LJ, et al: Survival, persistence, and isolation of the emerging multidrug-resistant pathogenic yeast Candida auris<\/i> on a plastic health care surface. J Clin Microbiol 55: 2996–3005, 2017.","DOI":"10.1128\/JCM.00921-17"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Piatti G, Sartini M, Cusato C, Schito AM: Colonization by Candida auris<\/i> in critically ill patients: role of cutaneous and rectal localization during an outbreak. J Hosp Infect 120: 85–9, 2022.","DOI":"10.1016\/j.jhin.2021.11.004"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Abe M, Katano H, Nagi M, Higashi Y, Sato Y, Kikuchi K, et al: Potency of gastrointestinal colonization and virulence of Candida auris<\/i> in a murine endogenous candidiasis. PLoS One 15: e0243223, 2020.","DOI":"10.1371\/journal.pone.0243223"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Lines A, Vardi-Flynn I, Searle C: Recurrent vulvovaginal candidiasis. BMJ 369: m1995, 2020.","DOI":"10.1136\/bmj.m1995"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Richter SS, Galask RP, Messer SA, Hollis RJ, Diekema DJ, Pfaller MA: Antifungal susceptibilities of Candida<\/i> species causing vulvovaginitis and epidemiology of recurrent cases. J Clin Microbiol 43: 2155–62, 2005.","DOI":"10.1128\/JCM.43.5.2155-2162.2005"},{"key":"38","unstructured":"38) Rezaei-Matehkolaei A, Shafiei S, Zarei-Mahmoudabadi A: Isolation, molecular identification, and antifungal susceptibility profiles of vaginal isolates of\u00a0Candida<\/i>\u00a0species. Iran J Microbiol 8: 410–7, 2016."},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Denning DW, Kneale M, Sobel JD, Rautemaa-Richardson R: Global burden of recurrent vulvovaginal candidiasis: a systematic review. Lancet Infect Dis 18: e339–47, 2018.","DOI":"10.1016\/S1473-3099(18)30103-8"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Fidel PL Jr, Sobel JD: Immunopathogenesis of recurrent vulvovaginal candidiasis. Clin Microbiol Rev 9: 335–48, 1996.","DOI":"10.1128\/CMR.9.3.335"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Yano J, Palmer GE, Eberle KE, Peters BM, Vogl T, McKenzie AN, et al: Vaginal epithelial cell-derived S100 alarmins induced by Candida albicans<\/i> via pattern recognition receptor interactions are sufficient but not necessary for the acute neutrophil response during experimental vaginal candidiasis. Infect Immun 82: 783–92, 2014.","DOI":"10.1128\/IAI.00861-13"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Peters BM, Palmer GE, Nash AK, Lilly EA, Fidel PL Jr, Noverr MC: Fungal morphogenetic pathways are required for the hallmark inflammatory response during Candida albicans<\/i> vaginitis. Infect Immun 82: 532–43, 2014.","DOI":"10.1128\/IAI.01417-13"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Yano J, Peters BM, Noverr MC, Fidel PL Jr: Novel mechanism behind the immunopathogenesis of vulvovaginal candidiasis: \u201cneutrophil anergy\u201d. Infect Immun 86: e00684-17, 2018.","DOI":"10.1128\/IAI.00684-17"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Monin L, Ushakov DS, Arnesen H, Bah N, Jandke A, Mu\u00f1oz-Ruiz M, et al: \u03b3\u03b4 T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis. Mucosal Immunol 13: 969–81, 2020.","DOI":"10.1038\/s41385-020-0305-7"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Iversen MB, Jensen SK, Hansen AL, Winther H, Issazadeh-Navikas S, Reinert LS, et al: NKT cell activation by local \u03b1-galactosylceramide administration decreases susceptibility to HSV-2 infection. Immunobiology 220: 762–8, 2015.","DOI":"10.1016\/j.imbio.2014.12.019"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Habbeddine M, Verbeke P, Delarbre C, Moutier R, Prieto S, Ojcius DM, et al: CD1d-restricted NKT cells modulate placental and uterine leukocyte populations during chlamydial infection in mice. Microbes Infect 15: 928–38, 2013.","DOI":"10.1016\/j.micinf.2013.08.006"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47) Ashkar AA, Rosenthal KL: Interleukin-15 and natural killer and NKT cells play a critical role in innate protection against genital herpes simplex virus type 2 infection. J Virol 77: 10168–71, 2003.","DOI":"10.1128\/JVI.77.18.10168-10171.2003"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48) Abe M, Kinjo Y, Sadamoto S, Shinozaki M, Nagi M, Shibuya K, et al: \u03b1-Galactosylceramide-stimulated invariant natural killer T-cells play a protective role in murine vulvovaginal candidiasis by Candida albicans<\/i>. PLoS One 16: e0259306, 2021.","DOI":"10.1371\/journal.pone.0259306"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49) Trautwein-Weidner K, Gladiator A, Kirchner FR, Becattini S, R\u00fclicke T, Sallusto F, et al: Antigen-specific Th17 cells are primed by distinct and complementary dendritic cell subsets in oropharyngeal candidiasis. PLoS Pathog 11: e1005164, 2015.","DOI":"10.1371\/journal.ppat.1005164"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50) Kumari V, Banerjee T, Kumar P, Pandey S, Tilak R: Emergence of non-albicans Candida<\/i> among candidal vulvovaginitis cases and study of their potential virulence factors, from a tertiary care center, North India. Indian J Pathol Microbiol 56: 144–7, 2013.","DOI":"10.4103\/0377-4929.118703"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51) Kennedy MA, Sobel JD: Vulvovaginal candidiasis caused by non-albicans Candida<\/i> species: new insights. Curr Infect Dis Rep 12: 465–70, 2010.","DOI":"10.1007\/s11908-010-0137-9"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52) Dan M, Poch F, Levin D: High rate of vaginal infections caused by non-C. albicans Candida<\/i> species among asymptomatic women. Med Mycol 40: 383–6, 2002.","DOI":"10.1080\/mmy.40.4.383.386"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53) Ferreira C, Gon\u00e7alves B, Vilas Boas D, Oliveira H, Henriques M, Azeredo J, et al: Candida tropicalis<\/i> biofilm and human epithelium invasion is highly influenced by environmental pH. Pathog Dis 74: ftw101, 2016.","DOI":"10.1093\/femspd\/ftw101"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54) Weerasekera MM, Wijesinghe GK, Jayarathna TA, Gunasekara CP, Fernando N, Kottegoda N, et al: Culture media profoundly affect Candida albicans<\/i> and Candida tropicalis<\/i> growth, adhesion and biofilm development. Mem Inst Oswaldo Cruz 111: 697–702, 2016.","DOI":"10.1590\/0074-02760160294"},{"key":"55","unstructured":"55) Pumeesat P, Muangkaew W, Ampawong S, Luplertlop N: Candida albicans<\/i> biofilm development under increased temperature. New Microbiol 40: 279–83, 2017."},{"key":"56","doi-asserted-by":"crossref","unstructured":"56) Alonso-Monge R, Prieto D, Coman I, Rochas S, Arana DM, Hidalgo-Vico S, et al: Identification of clinical isolates of\u00a0Candida albicans<\/i>\u00a0with increased fitness in colonization of the murine gut. J Fungi (Basel) 7: 695, 2021.","DOI":"10.3390\/jof7090695"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57) Gow NA, van de Veerdonk FL, Brown AJ, Netea MG: Candida albicans<\/i> morphogenesis and host defence: discriminating invasion from colonization. Nat Rev Microbiol 10: 112–22, 2011.","DOI":"10.1038\/nrmicro2711"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58) Ernst JF, Tielker D: Responses to hypoxia in fungal pathogens. Cell Microbiol 11: 183–90, 2009.","DOI":"10.1111\/j.1462-5822.2008.01259.x"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59) Hill DR, Brunner ME, Schmitz DC, Davis CC, Flood JA, Schlievert PM, et al: In vivo<\/i> assessment of human vaginal oxygen and carbon dioxide levels during and post menses. J Appl Physiol (1985) 99: 1582–91, 2005.","DOI":"10.1152\/japplphysiol.01422.2004"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60) Koshikawa T, Abe M, Nagi M, Miyazaki Y, Takemura H: Biofilm-formation capability depends on environmental oxygen concentrations in Candida<\/i> species. J Infect Chemother 28: 643–50, 2022.","DOI":"10.1016\/j.jiac.2022.01.010"}],"container-title":["Medical Mycology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/mmj\/65\/3\/65_67\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T04:51:39Z","timestamp":1725079899000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/mmj\/65\/3\/65_67\/_article"}},"subtitle":["Disease Mechanism, Virulence, and Relationship with Environmental Factors"],"short-title":[],"issued":{"date-parts":[[2024,7,31]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.3314\/mmj.24.006","relation":{},"ISSN":["2185-6486","2186-165X"],"issn-type":[{"type":"print","value":"2185-6486"},{"type":"electronic","value":"2186-165X"}],"subject":[],"published":{"date-parts":[[2024,7,31]]}}}