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J Am Acad Dermatol 37: 979–88, 1997.","DOI":"10.1016\/S0190-9622(97)70076-8"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Zhang YQ, Rao R: Beyond ergosterol: linking pH to antifungal mechanisms. Virulence 1: 551–4, 2010.","DOI":"10.4161\/viru.1.6.13802"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Newland JG, Abdel-Rahman SM: Update on terbinafine with a focus on dermatophytoses. Clin Cosmet Investig Dermatol 2: 49–63, 2009.","DOI":"10.2147\/CCID.S3690"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Mukherjee P, Leidich SD, Isham N, Leitner I, Ryder NS, Ghannoum MA: Clinical Trichophyton rubrum<\/i> strain exhibiting primary resistance to terbinafine. Antimicrob Agents Chemother 47: 82–6, 2003.","DOI":"10.1128\/AAC.47.1.82-86.2003"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Osborne CS, Leitner I, Favre B, Ryder NS: Amino acid substitution in Trichophyton rubrum<\/i> squalene epoxidase associated with resistance to terbinafine. Antimicrob Agents Chemother 49: 2840–4, 2005.","DOI":"10.1128\/AAC.49.7.2840-2844.2005"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Yamada T, Maeda M, Alshahni MM, Tanaka R, Yaguchi T, Bontems O, et al: Terbinafine resistance of Trichophyton<\/i> clinical isolates caused by specific point mutations in the squalene epoxidase gene. Antimicrob Agents Chemother 61: e00115-17, 2017.","DOI":"10.1128\/AAC.00115-17"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Astvad KMT, Hare RK, J\u00f8rgensen KM, Saunte DML, Thomsen PK, Arendrup MC: Increasing terbinafine resistance in Danish Trichophyton<\/i> isolates 2019\u20132020. J Fungi 8: 150, 2022.","DOI":"10.3390\/jof8020150"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Hwang JK, Bakotic WL, Gold JAW, Magro CM, Lipner SR: Isolation of terbinafine-resistant Trichophyton\u00a0rubrum<\/i> from onychomycosis patients who failed treatment at an academic center in New York, United States. J Fungi 9: 710, 2023.","DOI":"10.3390\/jof9070710"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Blanchard G, Amarov B, Fratti M, Salamin K, Bontems O, Chang YT, et al: Reliable and rapid identification of terbinafine resistance in dermatophytic nail and skin infections. J Eur Acad Dermatol Venereol 37: 2080–9, 2023.","DOI":"10.1111\/jdv.19253"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Gupta AK, Cooper EA, Wang T, Polla Ravi S, Lincoln SA, Piguet V, et al: Detection of squalene epoxidase mutations in United States patients with onychomycosis: implications for management. J Invest Dermatol 143: 2476–83.e2477, 2023.","DOI":"10.1016\/j.jid.2023.04.032"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Haghani I, Babaie M, Hoseinnejad A, Rezaei-Matehkolaei A, Mofarrah R, Yahyazadeh Z, et al: High prevalence of terbinafine resistance among Trichophyton mentagrophytes<\/i>\/T. interdigitale<\/i> species complex, a cross-sectional study from 2021 to 2022 in Northern Parts of Iran. Mycopathologia 189: 52, 2024.","DOI":"10.1007\/s11046-024-00855-0"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Mohammadi LZ, Shams-Ghahfarokhi M, Salehi Z, Razzaghi-Abyaneh M: Increased terbinafine resistance among clinical genotypes of Trichophyton mentagrophytes<\/i>\/T. interdigitale<\/i> species complex harboring squalene epoxidase gene mutations. J Mycol Med 34: 101495, 2024.","DOI":"10.1016\/j.mycmed.2024.101495"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Kano R, Kimura U, Kakurai M, Hiruma J, Kamata H, Suga Y, et al: Trichophyton indotineae<\/i> sp. nov.: a new highly terbinafine-resistant anthropophilic dermatophyte species. Mycopathologia 185: 947–58, 2020.","DOI":"10.1007\/s11046-020-00455-8"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Suzuki S, Mano Y, Furuya N, Fujitani K: Discovery of terbinafine low susceptibility Trichophyton rubrum<\/i> strain in Japan. Biocontrol Sci 23: 151–4, 2018.","DOI":"10.4265\/bio.23.151"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Hiruma J, Kitagawa H, Noguchi H, Kano R, Hiruma M, Kamata H, et al: Terbinafine-resistant strain of Trichophyton<\/i> interdigitale strain isolated from a tinea pedis patient. J Dermatol 46: 351–3, 2019.","DOI":"10.1111\/1346-8138.14809"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Noguchi H, Matsumoto T, Hiruma M, Kimura U, Kano R, Yaguchi T, et al: Tinea unguium caused by terbinafine-resistant Trichophyton rubrum<\/i> successfully treated with fosravuconazole. J Dermatol 46: e446–7, 2019.","DOI":"10.1111\/1346-8138.15033"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Kitauchi Y, Kumagai Y, Inoue-Masuda Y, Sugiura M, Sato T, Yaguchi T, et al: Tinea corporis caused by terbinafine-resistant Trichophyton rubrum<\/i> successfully treated with fosravuconazole. J Dermatol 48: e329–30, 2021.","DOI":"10.1111\/1346-8138.15900"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Noguchi H, Matsumoto T, Kubo M, Kimura U, Hiruma M, Tanaka M, et al: Effective response of dermatophytoma caused by terbinafine-resistant Trichophyton interdigitale<\/i> solely to topical efinaconazole. Mycopathologia 187: 421–2, 2022.","DOI":"10.1007\/s11046-022-00636-7"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Hiruma J, Kimura U, Noguchi H, Hiruma M, Harada K, Kano R: In vitro<\/i> azole susceptibility testing of Japanese isolates of terbinafine-resistant Trichophyton indotineae<\/i> and Trichophyton rubrum<\/i>. Med Mycol J 64: 23–5, 2023.","DOI":"10.3314\/mmj.22-00021"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Moreno-Sabater A, Normand AC, Bidaud AL, Cremer G, Foulet F, Brun S, et al: Terbinafine resistance in dermatophytes: a French multicenter prospective study. J Fungi 8: 220, 2022.","DOI":"10.3390\/jof8030220"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Kolarczykov\u00e1 D, Lyskov\u00e1 P, \u0160varcov\u00e1 M, Kuklov\u00e1 I, Dobi\u00e1\u0161 R, Mall\u00e1tov\u00e1 N, et al: Terbinafine resistance in Trichophyton mentagrophytes<\/i> and Trichophyton rubrum<\/i> in the Czech Republic: A prospective multicentric study. Mycoses 67: e13708, 2024.","DOI":"10.1111\/myc.13708"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Shao Y, Shao J, de Hoog S, Verweij P, Bai L, Richardson R, et al: Emerging antifungal resistance in Trichophyton mentagrophytes<\/i>: insights from susceptibility profiling and genetic mutation analysis. Emerg Microbes Infect 14: 2450026, 2025.","DOI":"10.1080\/22221751.2025.2450026"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Hiruma J, Noguchi H, Shimizu T, Hiruma M, Harada K, Kano R: Epidemiological study of antifungal-resistant dermatophytes isolated from Japanese patients. J Dermatol 50: 1068–71, 2023.","DOI":"10.1111\/1346-8138.16780"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Pashootan N, Shams-Ghahfarokhi M, Chaichi Nusrati A, Salehi Z, Asmar M, Razzaghi-Abyaneh M: Phylogeny, antifungal susceptibility, and point mutations of SQLE<\/i> gene in major pathogenic dermatophytes isolated from clinical dermatophytosis. Front Cell Infect Microbiol 12: 851769, 2022.","DOI":"10.3389\/fcimb.2022.851769"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Mock M, Monod M, Baudraz-Rosselet F, Panizzon RG: Tinea capitis dermatophytes: susceptibility to antifungal drugs tested in vitro<\/i> and in vivo<\/i>. Dermatology 197: 361–7, 1998.","DOI":"10.1159\/000018032"},{"key":"29","unstructured":"29) Clinical and Laboratory Standards Institute: Reference method for broth dilution antifungal susceptibility testing of filamentous fungi, 3rd edition, Clinical and Laboratory Standards Institute, Wayne, PA, 2017."},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Hiruma J, Noguchi H, Hase M, Tokuhisa Y, Shimizu T, Ogawa T, et al: Epidemiological study of terbinafine-resistant dermatophytes isolated from Japanese patients. J Dermatol 48: 564–7, 2021.","DOI":"10.1111\/1346-8138.15745"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Taghipour S, Shamsizadeh F, Pchelin IM, Rezaei-Matehhkolaei A, Zarei Mahmoudabadi A, Valadan R, et al: Emergence of terbinafine resistant Trichophyton mentagrophytes<\/i> in Iran, harboring mutations in the squalene epoxidase (SQLE) gene. Infect Drug Resist 13: 845–50, 2020.","DOI":"10.2147\/IDR.S246025"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Noguchi H, Matsumoto T, Hiruma M, Kimura U, Kashiwada-Nakamura K, Kubo M, et al: Cluster infection caused by a terbinafine-resistant dermatophyte at a group home: the first case series in Japan. Acta Derm Venereol 101: adv00563, 2021.","DOI":"10.2340\/00015555-3926"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Higuchi S, Noguchi H, Matsumoto T, Nojo H, Kano R: Terbinafine-resistant tinea pedis and tinea unguium in Japanese military personnel. J Dermatol 51: 1256–8, 2024.","DOI":"10.1111\/1346-8138.17389"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Evans EG, Sigurgeirsson B: Double blind, randomised study of continuous terbinafine compared with intermittent itraconazole in treatment of toenail onychomycosis. The LION Study Group. BMJ 318: 1031–5, 1999.","DOI":"10.1136\/bmj.318.7190.1031"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Mahmood HR, Shams-Ghahfarokhi M, Salehi Z, Razzaghi-Abyaneh M: Epidemiological trends, antifungal drug susceptibility and SQLE<\/i> point mutations in etiologic species of human dermatophytosis in Al-Diwaneyah, Iraq. Sci Rep 14: 12669, 2024.","DOI":"10.1038\/s41598-024-63425-w"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Kano R, Kimura U, Noguchi H, Hiruma M: Clinical isolate of a Multi-Antifungal-Resistant Trichophyton rubrum<\/i>. Antimicrob Agents Chemother 66: e02393-21, 2022.","DOI":"10.1128\/aac.02393-21"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Monod M, Feuermann M, Salamin K, Fratti M, Makino M, Alshahni MM, et al: Trichophyton rubrum<\/i> azole resistance mediated by a nw ABC transporter, TruMDR3. Antimicrob Agents Chemother 63: e00863-19, 2019.","DOI":"10.1128\/AAC.00863-19"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Yamada T, Yaguchi T, Maeda M, Alshahni MM, Salamin K, Guenova E, et al: Gene amplification of CYP51B<\/i> : a new mechanism of resistance to azole compounds in Trichophyton indotineae<\/i>. Antimicrob Agents Chemother 66: e00059-22, 2022.","DOI":"10.1128\/aac.00059-22"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Singh A, Masih A, Khurana A, Singh PK, Gupta M, Hagen F, et al: High terbinafine resistance in Trichophyton interdigitale<\/i> isolates in Delhi, India harbouring mutations in the squalene epoxidase gene. 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