{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T17:30:03Z","timestamp":1783704603925,"version":"3.55.0"},"reference-count":188,"publisher":"Opast Group LLC","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAR"],"abstract":"<jats:p>Addictive drugs affect sleep both in individuals currently using drugs and in individuals who have withdrawn from\ndrugs. In fact, sleep disturbances are reported by individuals for some drugs long after they have quit taking them\nand after other withdrawal symptoms have subsided. This suggests that addictive drugs and sleep share some of\nthe same neurobiological mechanisms. Sleep researchers may be studying the neurobiology of addictive drugs\nwithout knowing it. The purpose of this survey is to summarize the effects that addictive drugs have on sleep and\nstages of sleep. We demonstrate that different addictive drugs have differential effects on disturbance of sleep, in\ngeneral, and on specific stages of sleep either while the drug is on board or after withdrawal. Accordingly, these\nresults are intended to encourage sleep researchers to use their knowledge of sleep mechanisms to offer researchers\nof addictive drugs new insights of how addictive drugs might affect brain mechanisms. Also, these results should\nalert researchers of addiction that treatment for drug effects needs to consider treatment for sleep disturbances as\nwell. Treatment for addiction is rarely accompanied by treatment for sleep disturbances even though this survey\ndemonstrates they are clearly related.<\/jats:p>","DOI":"10.33140\/jar.03.02.01","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T01:11:26Z","timestamp":1564017086000},"source":"Crossref","is-referenced-by-count":19,"title":["Differential Effects of Addictive Drugs on Sleep and Sleep Stages"],"prefix":"10.33140","volume":"3","member":"18493","published-online":{"date-parts":[[2019,7,15]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"1. Gordon HW (2016) Laterality of brain activation for risk factors","DOI":"10.2174\/1874473709666151217121309"},{"key":"ref1","unstructured":"of addiction. Curr Drug Abuse Rev 9: 1-18."},{"key":"ref2","unstructured":"2. Gordon HW (2017) Hemispheric asymmetry of development"},{"key":"ref3","unstructured":"due to drug exposure. J Sys Integrative Neurosci 3: 1-6."},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"3. Adan A (1994) Chronotype and personality factors in the daily","DOI":"10.1111\/j.1360-0443.1994.tb00926.x"},{"key":"ref5","unstructured":"consumption of alcohol and psycho stimulants. Addiction 89:"},{"key":"ref6","unstructured":"455-462."},{"key":"ref7","unstructured":"4. Prat G, Adan A (2011) Influence of circadian typology on drug"},{"key":"ref8","unstructured":"consumption, hazardous alcohol use, and hangover symptoms."},{"key":"ref9","unstructured":"Chronobiol Int 28: 248-257."},{"key":"ref10","unstructured":"5. Tavernier R, Munroe M, Willoughby T (2015) Perceived"},{"key":"ref11","unstructured":"morningness-eveningness predicts academic adjustment and"},{"key":"ref12","unstructured":"substance use across university, but social jetlag is not to blame."},{"key":"ref13","unstructured":"Chronobiol Int 32: 1233-1245."},{"key":"ref14","unstructured":"6. Branstetter SA, Horton WJ, Mercincavage M, Buxton OM"},{"key":"ref15","unstructured":"(2016) Severity of nicotine addiction and disruptions in sleep"},{"key":"ref16","unstructured":"mediated by early awakenings. Nicotine Tob Res 18: 2252-2259."},{"key":"ref17","unstructured":"7. Morasco BJ, O\u2019Hearn D, Turk DC, Dobscha SK (2014)"},{"key":"ref18","unstructured":"Associations between prescription opioid use and sleep"},{"key":"ref19","unstructured":"impairment among veterans with chronic pain. Pain Medicine"},{"key":"ref20","unstructured":"15: 1902-1910."},{"key":"ref21","unstructured":"8. Hartwell EE, Pfeifer JG, McCauley JL, Moran-Santa Maria M,"},{"key":"ref22","unstructured":"Back SE (2014) Sleep disturbance and pain among individuals"},{"key":"ref23","unstructured":"with prescription and opioid dependence. Addictive Behav 39:"},{"key":"ref24","unstructured":"1537-1542."},{"key":"ref25","unstructured":"9. Thomas MB, Shaw DS, Forbes EE, Sitnick SL, Hasler BP"},{"key":"ref26","unstructured":"(2016) The hazards of bad sleep-sleep duration and quality as"},{"key":"ref27","unstructured":"predictors of adolescent alcohol and cannabis use. Drug Alcohol"},{"key":"ref28","unstructured":"Depend 168: 335-339."},{"key":"ref29","unstructured":"10. Wong MM, Brower KJ, Nigg JT, Zucker RA (2010) Childhood"},{"key":"ref30","unstructured":"sleep problems, response inhibition, and alcohol and drug"},{"key":"ref31","unstructured":"outcomes in adolescence and young adulthood. Alcohol Clin"},{"key":"ref32","unstructured":"Exp Res 34: 1033-1044."},{"key":"ref33","unstructured":"11. Babson KA, Boden MT, Bonn-Miller MO (2013) The impact"},{"key":"ref34","unstructured":"of perceived sleep quality and sleep efficiency\/duration on"},{"key":"ref35","unstructured":"cannabis use during a self-guided quit attempt. Addictive"},{"key":"ref36","unstructured":"Behav38: 2707-2713."},{"key":"ref37","unstructured":"12. Gulick D, Gamsby JJ (2018) Racing the clock: the role of"},{"key":"ref38","unstructured":"circadian rhythmicity in addiction across the lifespan. Pharmacol"},{"key":"ref39","unstructured":"Ther 128: 124-139."},{"key":"ref40","unstructured":"13. Logan RW, Williams W, McClung CA (2014) Circadian rhythms"},{"key":"ref41","unstructured":"and addiction: Mechanistic insights and future directions. Behav"},{"key":"ref42","unstructured":"Neurosci 128: 387-412."},{"key":"ref43","unstructured":"14. McClung CA, Sidiropoulou K, Vitaterna M, Takahashi JS,"},{"key":"ref44","unstructured":"White FJ, et al. (2005) Regulation of dopaminergic transmission"},{"key":"ref45","unstructured":"and cocaine reward by the Clock gene. PNAS 102: 9377-9381."},{"key":"ref46","unstructured":"15. Parekh PK, Ozburna R, McClung CA (2015) Circadian clock"},{"key":"ref47","unstructured":"genes: Effects on dopamine, reward and addiction. Alcohol"},{"key":"ref48","unstructured":"49: 341-349."},{"key":"ref49","unstructured":"16. Falcon E, Ozburn A, Mukherjee S, Roybal K, McClung CA"},{"key":"ref50","unstructured":"(2013) Differential regulation of the Period Genes in striatal"},{"key":"ref51","unstructured":"regions following cocaine exposure. PLOS ONE 8: e66438."},{"key":"ref52","unstructured":"17. Hasler BP, Smith LJ, Cousins JC, Bootzin RR (2012) Circadian"},{"key":"ref53","doi-asserted-by":"crossref","unstructured":"rhythms, Sleep, and Substance abuse. Sleep Med Rev 16: 67-81.","DOI":"10.1016\/j.smrv.2011.03.004"},{"key":"ref54","unstructured":"18. Schmoll C, Lascaratos G, Dhillon B, Skene D, Riha RL (2011)"},{"key":"ref55","unstructured":"The role of retinal regulation of sleep in health and disease."},{"key":"ref56","unstructured":"Sleep Med Rev 15: 107-113."},{"key":"ref57","unstructured":"19. Roy M, Roy A, Smelson D, Brown S. Weinberger L (1997)"},{"key":"ref58","unstructured":"Reduced blue cone electroretinogram in withdrawn cocaine"},{"key":"ref59","unstructured":"dependent patients: a replication. Biol Psychiat 42: 631-633."},{"key":"ref60","unstructured":"20. Smelson Da, Roy A, Roy M, Tershakovec D, Englehart C,"},{"key":"ref61","unstructured":"at al. (2001) Electroretinogram and cure-elicited craving in"},{"key":"ref62","unstructured":"withdrawn cocaine-dependent patients: a replication. Am J"},{"key":"ref63","unstructured":"Drug Alcohol Abuse 27: 391-397."},{"key":"ref64","unstructured":"21. Garcia AN, Salloum IH (2015) Polysomnographic sleep"},{"key":"ref65","unstructured":"disturbances in nicotine, caffeine, alcohol, cocaine, opioid, and"},{"key":"ref66","unstructured":"cannabis use: a focused review. Am J Addictions 24: 590-598."},{"key":"ref67","unstructured":"22. Schierenbeck T, Riemann D, Berger M, Hornyak M (2008)"},{"key":"ref68","unstructured":"Effect of illicit recreational drugs upon sleep: cocaine ecstasy,"},{"key":"ref69","unstructured":"and marijuana. Sleep Med Rev 12: 381-389."},{"key":"ref70","unstructured":"23. Angarita GA, Emadi N, Hodges S, Morgan PT (2016) Sleep"},{"key":"ref71","unstructured":"abnormalities associated with alcohol, cannabis, cocaine, and"},{"key":"ref72","unstructured":"opiate use: a comprehensive review. Addict Sci Clin Pract 11: 9."},{"key":"ref73","unstructured":"24. Morgan PT, Pace-Schott, EF, Sahul ZH, Coric V, Stickgold R,"},{"key":"ref74","unstructured":"et al. (2006) Sleep, sleep-dependent procedural learning and"},{"key":"ref75","unstructured":"vigilance in chronic cocaine users: evidence for occult insomnia,"},{"key":"ref76","unstructured":"Drug Alcohol Depend 82: 238-249."},{"key":"ref77","doi-asserted-by":"crossref","unstructured":"25. Conroy DA, Arnedt JT (2014) Sleep and substance use disorders:","DOI":"10.1007\/s11920-014-0487-3"},{"key":"ref78","unstructured":"an update. Curr Psychiat Rep 16: 487-493."},{"key":"ref79","unstructured":"26. Thompson PM, Gillin JC, Golshan S, Irwin M (1995)"},{"key":"ref80","unstructured":"Polygraphic sleep measures differentiate alcoholics and"},{"key":"ref81","unstructured":"stimulant abusers during short-term abstinence. Biol Psychiat"},{"key":"ref82","unstructured":"38: 831-836."},{"key":"ref83","unstructured":"27. Matuskey D, Pittman B, Forselius E, Malison RT, Morgan PT"},{"key":"ref84","unstructured":"(2011) A multistudy analysis of the effects of early cocaine"},{"key":"ref85","unstructured":"abstinence on sleep. Drug Alcohol Depend 115: 62-66."},{"key":"ref86","unstructured":"28. Angarita GA, Canavan SV, Forelius E, Bessette A, Pittman B, et"},{"key":"ref87","unstructured":"al. (2014) Abstinence-related changes in sleep during treatment"},{"key":"ref88","unstructured":"for cocaine dependence. Drug Alcohol Depend 134: 343-347."},{"key":"ref89","unstructured":"29. Irwin MR, Bjurstrom MF, Olmstead R (2016) Polysomnographic"},{"key":"ref90","unstructured":"measures of sleep in cocaine dependence and alcohol"},{"key":"ref91","unstructured":"dependence: Implications for age-related loss of slow wave,"},{"key":"ref92","unstructured":"stage 3 sleep. Addiction111: 1084-1092."},{"key":"ref93","unstructured":"30. Soldatos CR, Kales JD, Scharf MB, Bixler EO, Kales A (1980)"},{"key":"ref94","unstructured":"Cigarette smoking associated with sleep difficulty. Science"},{"key":"ref95","unstructured":"207: 551-553."},{"key":"ref96","unstructured":"31. Zhang L, Samet J, Caffo B, Punjabi NM (2006) Cigarette"},{"key":"ref97","unstructured":"smoking and nocturnal sleep architecture. Am J Epidemiol"},{"key":"ref98","unstructured":"164: 529-537."},{"key":"ref99","unstructured":"32. Jaehne A, Unbehaun T, Feige B, Cohrs S, Rodenbeck A, et al."},{"key":"ref100","unstructured":"(2015) Sleep changes in smokers before, during and 3 months"},{"key":"ref101","unstructured":"after nicotine withdrawal. Addict Biol 20: 747-765."},{"key":"ref102","unstructured":"33. Moreno-Couti\u00f1o A, Calder\u00f3n-Ezqquerro C, Drucker-Col\u00edn R"},{"key":"ref103","unstructured":"(2006) Long-term changes in sleep and depressive symptoms"},{"key":"ref104","unstructured":"of smokers in abstinence. Nicotine Tob Res 9: 389-396."},{"key":"ref105","unstructured":"34. Feinberg I, Jones R, Walker J, Cavness C, Floyd T (1976)"},{"key":"ref106","unstructured":"Effects of marijuana extract and tetrahydrocannabinol on"},{"key":"ref107","unstructured":"electroencephalographic sleep patterns. Clin Pharmacol Ther"},{"key":"ref108","unstructured":"19: 782-794."},{"key":"ref109","unstructured":"35. Feinberg I, Jones R, Walker JM, Cleve MS, Cavness BA, et"},{"key":"ref110","unstructured":"al. (1975) Effects of high dosage delta-9-tetrahydrocannabinol"},{"key":"ref111","unstructured":"on sleep patterns in man. Clin Pharmacol Ther 17: 458-466."},{"key":"ref112","unstructured":"36. Bolla KI, Lesage SR, Gamaldo CE, Neubauer DN, Funderburk"},{"key":"ref113","unstructured":"FR, Cadet JL, et al. (2008) Sleep disturbance in heavy marijuana"},{"key":"ref114","unstructured":"users. Sleep 31: 901-908."},{"key":"ref115","unstructured":"37. Vandrey R, Smith MT, McCann UD, Budney AJ, Curran EM"},{"key":"ref116","unstructured":"(2011) Sleep disturbance and the effects of extended-release"},{"key":"ref117","unstructured":"zolpidem during cannabis withdrawal. Drug Alcohol Depend"},{"key":"ref118","unstructured":"117: 38-44."},{"key":"ref119","unstructured":"38. Bolla KI, Lesage SR, Gamaldo CE, Neubauer DN, Wang N-Y,"},{"key":"ref120","unstructured":"et al. (2010) Polysomnogram changes in marijuana users who"},{"key":"ref121","unstructured":"report sleep disturbances during prior abstinence. Sleep Med"},{"key":"ref122","unstructured":"11: 882-889."},{"key":"ref123","unstructured":"39. Budney AJ, Moore BA, Vandrey RG, Huges JR (2003) The"},{"key":"ref124","unstructured":"time course and significance of cannabis withdrawal. J abnorm"},{"key":"ref125","unstructured":"Psychol 112: 393-402."},{"key":"ref126","unstructured":"40. Allsop DJ, Norberg MM, Copeland J, Fu S, Budney AJ (2011)"},{"key":"ref127","unstructured":"The Cannabis Withdrawal Scale development: patterns and"},{"key":"ref128","unstructured":"predictors of cannabis withdrawal and distress. Drug Alcohol"},{"key":"ref129","unstructured":"Depend 119: 123-129."},{"key":"ref130","unstructured":"41. Lee D, Schroeder JR, Karschner EL, Goodwin RS, Hirvonen J,"},{"key":"ref131","unstructured":"et al. (2014) Cannabis withdrawal in chronic, frequent cannabis"},{"key":"ref132","unstructured":"smokers during sustained abstinence with a closed residential"},{"key":"ref133","unstructured":"environment. Am J Addictions 23: 234-242."},{"key":"ref134","unstructured":"42. Vandrey R, Budney AJ, Kamon JL, Stanger C (2005) Cannabis"},{"key":"ref135","unstructured":"withdrawal in adolescent treatment seekers. Drug Alcohol"},{"key":"ref136","unstructured":"Depend 78: 205-210."},{"key":"ref137","unstructured":"43. Mehtry V, Nizamie SH, Parvez N, Pradhan N (2014) Sleep"},{"key":"ref138","unstructured":"profile in opioid dependence: a polysomnographic case-control"},{"key":"ref139","unstructured":"study. J Clin Neurophys 31: 517-522."},{"key":"ref140","unstructured":"44. Howe RC, Hegge FW, Phillips JL (1980) Acute heroin abstinence"},{"key":"ref141","unstructured":"in man: II. Alterations in rapid eye movement (REM) sleep."},{"key":"ref142","unstructured":"Drug Alcohol Depend 6: 149-161."},{"key":"ref143","unstructured":"45. Asaad TA, Ghanem MH, Samee AMA, El-Habiby MM (2011)"},{"key":"ref144","unstructured":"Sleep profile in patients with chronic opioid abuse. Addict Dis"},{"key":"ref145","unstructured":"Treatment 10: 21-28."},{"key":"ref146","unstructured":"46. Howe RC, Hegge FW, Phillips JL (1980) Acute heroin"},{"key":"ref147","unstructured":"abstinence in man: I. Changes in behavior and sleep. Drug"},{"key":"ref148","unstructured":"Alcohol Depend 5: 341-356."},{"key":"ref149","unstructured":"47. Imatoh N, Nakazawa Y, Ohshima H, Ishibashi M, Yokoyama T"},{"key":"ref150","unstructured":"(1986) Circadian rhythm of REM sleep of chronic alcoholics"},{"key":"ref151","unstructured":"during alcohol withdrawal. Drug Alcohol Depend 18: 77-85."},{"key":"ref152","unstructured":"48. Drummond SPA, Gillin JC, Smit TL, DeModena A (1998)"},{"key":"ref153","unstructured":"The sleep of abstinent pure primary alcoholic patients: Natural"},{"key":"ref154","unstructured":"course and relationship to relapse. Alcohol Clin Exp Res 22:"},{"key":"ref155","unstructured":"1796-1802."},{"key":"ref156","unstructured":"49. Gann H, van Calker D, Feige B, Cloot O, Br\u00fcck R, et al. (2004)"},{"key":"ref157","unstructured":"Polysomnographic comparison between patients with primary"},{"key":"ref158","unstructured":"alcohol dependency during subacute withdrawal and patients"},{"key":"ref159","unstructured":"with a major depression. Eur Arch Psychiat Clin Neurosci"},{"key":"ref160","unstructured":"254: 263-271."},{"key":"ref161","doi-asserted-by":"crossref","unstructured":"50. Snyder S, Karacan I (1985) Sleep patterns of sober chronic","DOI":"10.1159\/000118169"},{"key":"ref162","unstructured":"alcoholics. Neuropsychobiology 13: 97-100."},{"key":"ref163","doi-asserted-by":"crossref","unstructured":"51. Taylor BJ, Hasler BP (2018) Chronotype and mental health:","DOI":"10.1007\/s11920-018-0925-8"},{"key":"ref164","unstructured":"Recent advances. Curr Psychiat Rep 20: 59-69."},{"key":"ref165","unstructured":"52. Hasler BP, Casement MD, Sitnick SL, Shaw DS, Forbes EE"},{"key":"ref166","unstructured":"(2017) Eveningness among late adolescent males predicts neural"},{"key":"ref167","unstructured":"reactivity to reward and alcohol dependence two years later."},{"key":"ref168","unstructured":"Behav Brain Res 327:112-120."},{"key":"ref169","unstructured":"53. Song J, Feng P, Zhao X, Xu W, Xiao L, et al. (2018) Chronotype"},{"key":"ref170","unstructured":"regulates the neural basis of response inhibition during the"},{"key":"ref171","unstructured":"daytime. Chronobiol Int 35: 208-218."},{"key":"ref172","unstructured":"54. Telzer EH, Fuligni AJ, Lieberman MD, Galv\u00e1n A (2013) The"},{"key":"ref173","unstructured":"effects of poor quality sleep on brain function and risk taking"},{"key":"ref174","unstructured":"in adolescence. Neuro Image 71: 275-283."},{"key":"ref175","unstructured":"55. Berro LF, Tufik S, Andersen ML (2015) Sleep impairment: the"},{"key":"ref176","unstructured":"possible link between childhood ADHD, sensation seeking, and"},{"key":"ref177","unstructured":"cocaine dependence. J Atten Disord 19: 351."},{"key":"ref178","unstructured":"56. Hodges SE, Pittman B, Morgan PT (2017) Sleep perception"},{"key":"ref179","unstructured":"and misperception in chronic cocaine users during abstinence."},{"key":"ref180","unstructured":"Sleep 40: 1-7."},{"key":"ref181","unstructured":"57. Hack SP, Christie MJ. Adaptations in adenosine signaling in"},{"key":"ref182","unstructured":"drug dependence: Therapeutic implications. Crit Rev Neurobiol"},{"key":"ref183","unstructured":"15: 235-274."},{"key":"ref184","unstructured":"58. Datta S, Maclean RR. Neurobiological mechanisms for the"},{"key":"ref185","unstructured":"regulation of mammalian sleep-wake behavior: Reinterpretation"},{"key":"ref186","unstructured":"of historical evidence and inclusion of contemporary cellular"},{"key":"ref187","unstructured":"and molecular evidence. Neurosci Biobehav Rev 31: 775-824."}],"container-title":["Journal of Addiction Research"],"original-title":[],"deposited":{"date-parts":[[2019,7,28]],"date-time":"2019-07-28T10:47:51Z","timestamp":1564310871000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.opastonline.com\/wp-content\/uploads\/2019\/07\/differential-effects-of-addictive-drugs-on-sleep-and-sleep-stages-jar-19.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,15]]},"references-count":188,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,7,15]]}},"URL":"https:\/\/doi.org\/10.33140\/jar.03.02.01","relation":{},"ISSN":["2573-9514"],"issn-type":[{"value":"2573-9514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,15]]}}}