{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T04:49:10Z","timestamp":1775710150940,"version":"3.50.1"},"reference-count":0,"publisher":"Opast Group LLC","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Exp Immunol"],"abstract":"<jats:p>Traumatic brain injury (TBI) is a major health concern, sometimes leading to long-term neurological disability, especially\nin children, young adults, and war veterans. Although the research investigators and clinicians have applied different\ntreatment strategies or neurosurgical procedures to solve this health issue, we are still in need of effective therapy to\nhalt the pathogenesis of brain injury. Earlier we have reported that sodium benzoate (NaB), a metabolite of cinnamon\nand a Food and Drug Administration-approved drug against urea cycle disorders and glycine encephalopathy, protects\nneurons in animal models of Parkinson\u2019s disease and Alzheimer\u2019s disease. This study was undertaken to examine the\ntherapeutic efficacy of NaB in controlled cortical impact (CCI)-induced preclinical mouse model of TBI. Oral treatment\nwith NaB, but not sodium formate (NaFO), was found to decrease the activation of microglia and astrocytes and inhibits\nthe expression of inducible nitric oxide synthase (iNOS) in hippocampus and cortex of CCI-insulted mice. Further,\nadministration of NaB also reduced the vascular damage and decreased the size of lesion cavity in the brain of CCIinduced mice. Importantly, NaB-treated mice showed significant improvements in memory and locomotor functions as\nwell as displayed substantial reduction in depression like behaviors. These results delineate a novel neuroprotective\nproperty of NaB, highlighting its possible therapeutic importance in TBI.<\/jats:p>","DOI":"10.33140\/jcei.11.01.03","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T13:49:19Z","timestamp":1775569759000},"page":"01-16","source":"Crossref","is-referenced-by-count":0,"title":["Corrected Version: Sodium Benzoate, A Metabolite of Cinnamon and A Food Additive, Improves Cognitive Functions in Mice After Controlled Cortical Impact Injury"],"prefix":"10.33140","volume":"11","author":[{"given":"Suresh B.","family":"Rangasamy","sequence":"first","affiliation":[{"name":"Division of Research and Development, Jesse Brown Veterans Affairs Medical Center, Chicago, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumita","family":"Raha","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences, Rush University Medical Center, Chicago, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sridevi","family":"Dasarathi","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences, Rush University Medical Center, Chicago, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalipada","family":"Pahan","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences, Rush University Medical Center, Chicago, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18493","published-online":{"date-parts":[[2026,3,30]]},"container-title":["Journal of Clinical &amp; Experimental Immunology"],"original-title":["Corrected Version: Sodium Benzoate, A Metabolite of Cinnamon and A Food Additive, Improves Cognitive Functions in Mice After Controlled Cortical Impact Injury"],"deposited":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T04:10:42Z","timestamp":1775707842000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.opastpublishers.com\/open-access-articles\/corrected-version-sodium-benzoate-a-metabolite-of-cinnamon-and-a-food-additive-improves-cognitive-functions-in-mice-after-controll-10534.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,30]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2026,3,30]]}},"URL":"https:\/\/doi.org\/10.33140\/jcei.11.01.03","relation":{},"ISSN":["2475-6296"],"issn-type":[{"value":"2475-6296","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,30]]}}}