{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T09:47:18Z","timestamp":1785750438933,"version":"3.56.0"},"reference-count":0,"publisher":"Opast Group LLC","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Exp Immunol"],"abstract":"<jats:p>Multiple sclerosis (MS) is the most common human demyelinating disease of the CNS. The IL-12 family of cytokines\nhas four members which are IL-12 (p40:p35), IL-23 (p40:p19), the p40 monomer (p40), and the p40 homodimer (p402\n).\nSince all four members contain p40 in different forms, it is important to use specific monoclonal antibody (mAb) to\ncharacterize these molecules. Here, by using such mAb, we describe selective loss of p40 in serum of MS patients as\ncompared to healthy controls. Similarly, we also observed decrease in p40 and increase in IL-12, IL-23 and p402\n in\nserum of mice with experimental autoimmune encephalomyelitis (EAE), an animal model of MS, as compared to control\nmice. Interestingly, weekly supplementation of mouse and human recombinant p40 ameliorated clinical symptoms and\ndisease progression of EAE. On the other hand, IL-12, IL-23 and p402 did not exhibit such inhibitory effect. In addition\nto EAE, p40 also suppressed collagen-induced arthritis in mice. Using IL-12R\u03b21-\/-, IL-12R\u03b22-\/- and IL-12R\u03b21+\/-\/IL12R\u03b22-\/- mice, we observed that p40 required IL-12R\u03b21, but not IL-12R\u03b22, to suppress EAE. Interestingly, p40 arrested\nIL-12-, IL-23- or p402\n-mediated internalization of IL-12R\u03b21, but neither IL-12R\u03b22 nor IL-23R, protected regulatory\nT cells, and suppressed Th1 and Th17 biasness. These studies identify p40 as a new anti-autoimmune cytokine with\nbiological role different from IL-12, IL-23 and p402\n in which it attenuates autoimmune signaling via suppression of IL12R\u03b21 internalization, which may be beneficial in patients with MS and other autoimmune disorders.<\/jats:p>","DOI":"10.33140\/jcei.11.03.02","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:51:49Z","timestamp":1784292709000},"page":"01-38","source":"Crossref","is-referenced-by-count":0,"title":["Corrected Version: IL-12 p40 Monomer is Different from Other IL-12 Family Members to Selectively Inhibit IL-12R\u03b21 Internalization and Suppress EAE"],"prefix":"10.33140","volume":"11","author":[{"given":"Susanta","family":"Mondal","sequence":"first","affiliation":[{"name":"Department of Neurological Sciences, Rush University Medical Center, Chicago, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhuchhanda","family":"Kundu","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences, Rush University Medical Center, Chicago, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malabendu","family":"Jana","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences, Rush University Medical Center, Chicago, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"B. Rangasamy","sequence":"additional","affiliation":[{"name":"Division of Research and Development, Jesse Brown Veterans Affairs Medical Center, Chicago, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khushbu","family":"K. Modi","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences, Rush University Medical Center, Chicago, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roumen","family":"Balabanov","sequence":"additional","affiliation":[{"name":"Department of Neurology, Northwestern University, Chicago, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6048-9598","authenticated-orcid":false,"given":"Kalipada","family":"Pahan","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences, Rush University Medical Center, Chicago, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18493","published-online":{"date-parts":[[2026,7,13]]},"container-title":["Journal of Clinical &amp; Experimental Immunology"],"original-title":["Corrected Version: IL-12 p40 Monomer is Different from Other IL-12 Family Members to Selectively Inhibit IL-12R\u03b21 Internalization and Suppress EAE"],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T09:04:50Z","timestamp":1785747890000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.opastpublishers.com\/open-access-articles\/corrected-version-il12-p40-monomer-is-different-from-other-il12-family-members-to-selectively-inhibit-il12r1-internalization-and-s-10987.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,13]]},"references-count":0,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2026,7,13]]}},"URL":"https:\/\/doi.org\/10.33140\/jcei.11.03.02","relation":{},"ISSN":["2475-6296"],"issn-type":[{"value":"2475-6296","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,13]]}}}