{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T05:04:41Z","timestamp":1775624681861,"version":"3.50.1"},"reference-count":12,"publisher":"Tottori University Faculty of Medicine","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Yonago Acta Med."],"published-print":{"date-parts":[[2019]]},"DOI":"10.33160\/yam.2019.03.022","type":"journal-article","created":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T18:11:06Z","timestamp":1553710266000},"page":"159-162","source":"Crossref","is-referenced-by-count":5,"title":["Recurrent Erythema Nodosum in a Child with a &lt;i&gt;SHOC2&lt;\/i&gt; Gene Mutation"],"prefix":"10.33160","volume":"62","author":[{"given":"Tetsuya","family":"Okazaki","sequence":"first","affiliation":[{"name":"*Division of Child Neurology, Department of Brain and Neurosciences, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8504, Japan"},{"name":"\u2020Department of Clinical Genetics, Tottori University Hospital, Yonago 683-8504, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Saito","sequence":"additional","affiliation":[{"name":"*Division of Child Neurology, Department of Brain and Neurosciences, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8504, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunari","family":"Sugita","sequence":"additional","affiliation":[{"name":"\u2021Division of Dermatology, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8504, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanae","family":"Nosaka","sequence":"additional","affiliation":[{"name":"\u00a7Division of Organ Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8504, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koyo","family":"Ohno","sequence":"additional","affiliation":[{"name":"*Division of Child Neurology, Department of Brain and Neurosciences, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8504, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumie","family":"Hiraoka","sequence":"additional","affiliation":[{"name":"\u2020Department of Clinical Genetics, Tottori University Hospital, Yonago 683-8504, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Kasagi","sequence":"additional","affiliation":[{"name":"\u2020Department of Clinical Genetics, Tottori University Hospital, Yonago 683-8504, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsutaka","family":"Ebiki","sequence":"additional","affiliation":[{"name":"||The Development of Innovative Future Medical Treatment, Graduate School of Medical Sciences, Tottori University, Yonago 683-8504, Japan"},{"name":"\u00b6KUSUNOKI - SCALE Incorporated, Yonago 683-0832, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Narai","sequence":"additional","affiliation":[{"name":"**Division of Pediatrics and Perinatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8504, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Kawashima","sequence":"additional","affiliation":[{"name":"**Division of Pediatrics and Perinatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8504, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichi","family":"Takano","sequence":"additional","affiliation":[{"name":"\u2020\u2020Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8504, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masachika","family":"Kai","sequence":"additional","affiliation":[{"name":"\u2021\u2021Division of Technical Department, Tottori University, Yonago 683-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Adachi","sequence":"additional","affiliation":[{"name":"\u00a7\u00a7Research Initiative Center, Organization for Research Initiative and Promotion, Tottori University, Yonago 683-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"\u2021Division of Dermatology, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8504, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Nanba","sequence":"additional","affiliation":[{"name":"\u2020Department of Clinical Genetics, Tottori University Hospital, Yonago 683-8504, Japan"},{"name":"||||Research Strategy Division, Organization for Research Initiative and Promotion, Tottori University, Yonago 683-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Maegaki","sequence":"additional","affiliation":[{"name":"*Division of Child Neurology, Department of Brain and Neurosciences, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8504, Japan"},{"name":"\u2020Department of Clinical Genetics, Tottori University Hospital, Yonago 683-8504, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18656","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1 Komatsuzaki S, Aoki Y, Niihori T, Okamoto N, Hennekam RC, Hopman S,  et al.Mutation analysis of the SHOC2 gene in Noonan-like syndrome and in hematologic malignancies. J Hum Genet. 2010;55:801-9. PMID: 20882035","DOI":"10.1038\/jhg.2010.116"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2 Baldassarre G, Mussa A, Banaudi E, Rossi C, Tartaglia M, Silengo M,  et al.Phenotypic variability associated with the invariant SHOC2 c.4A&gt;G (p.Ser2Gly) missense mutation. Am J Med Genet A. 2014;164A:3120-5. PMID: 25331583","DOI":"10.1002\/ajmg.a.36697"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3 Chowaniec M, Starba A, Wiland P.Erythema nodosum-review of the literature. Reumatologia. 2016;54:79-82. PMID: 27407284","DOI":"10.5114\/reum.2016.60217"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4 Uehara T, Hosogaya N, Matsuo N, Kosaki K.Systemic lupus erythematosus in a patient with Noonan syndrome-like disorder with loose anagen hair 1: More than a chance association. Am J Med Genet A. 2018;176:1662-6. PMID: 29737035","DOI":"10.1002\/ajmg.a.38834"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5 Golomb L, Sagiv A, Pateras IS, Maly A, Krizhanovsky V, Gorgoulis VG,  et al.Age-associated inflammation connects RAS-induced senescence to stem cell dysfunction and epidermal malignancy. Cell Death Differ. 2015;22:1764-74. PMID: 26434982","DOI":"10.1038\/cdd.2015.21"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6 Kane J, Berrebi K, McLean R, Petkiewicz S, Hay B, Martin M,  et al.Noonan syndrome with loose anagen hair associated with trichorrhexis nodosa and trichoptilosis. Clin Case Rep. 2017;5:1152-4. PMID: 28680615","DOI":"10.1002\/ccr3.1011"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7 Dhurat RP, Deshpande DJ.Loose anagen hair syndrome. Int J Trichology. 2010;2:96-100.","DOI":"10.4103\/0974-7753.77513"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8 Dicle O, Velipasaoglu S, Ozenci CC, Akkoyunlu G, Demir N.Report of a new case with loose anagen hair syndrome and scanning electron microscopy findings. Int J Dermatol. 2008;47:936-8.","DOI":"10.1111\/j.1365-4632.2008.03697.x"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9 Mukhopadhyay A, Krishnaswami SR, Yu BD.Activated Kras alters epidermal homeostasis of mouse skin, resulting in redundant skin and defective hair cycling. J Invest Dermatol. 2011;131:311-9. PMID: 20944652","DOI":"10.1038\/jid.2010.296"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10 Doma E, Rupp C, Baccarini M.EGFR-ras-raf signaling in epidermal stem cells: roles in hair follicle development, regeneration, tissue remodeling and epidermal cancers. Int J Mol Sci. 2013;14:19361-84. PMID: 2407193","DOI":"10.3390\/ijms141019361"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11 Cordeddu V, Di Schiavi E, Pennacchio LA, Ma\u2019ayan A, Sarkozy A, Fodale V,  et al.Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair. Nat Genet. 2009;41:1022-6. PMID: 19684605","DOI":"10.1038\/ng.425"},{"key":"12","doi-asserted-by":"publisher","unstructured":"12 M\u00fchlebner A, van Scheppingen J, Hulshof HM, Scholl T, Iyer AM, Anink JJ,  et al.Novel Histopathological Patterns in Cortical Tubers of Epilepsy Surgery Patients with Tuberous Sclerosis Complex. PLoS One. 2016;11:e0157396. DOI:10.1371\/journal.pone.0157396 PMID: 27295297","DOI":"10.1371\/journal.pone.0157396"}],"container-title":["Yonago Acta Medica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/yam\/62\/1\/62_2019.03.022\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:52:46Z","timestamp":1559350366000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/yam\/62\/1\/62_2019.03.022\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.33160\/yam.2019.03.022","relation":{},"ISSN":["1346-8049"],"issn-type":[{"value":"1346-8049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}