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Bartok B, Firestein GS. Fibroblast-like                    synoviocytes: key effector cells in rheumatoid arthritis. Immunol Rev.                    2010;233:233-55. PMID:20193003,                    DOI:10.1111\/j.0105-2896.2009.00859.x","DOI":"10.1111\/j.0105-2896.2009.00859.x"},{"key":"2","doi-asserted-by":"publisher","unstructured":"2. Ospelt C. Synovial fibroblasts in 2017.                    RMD Open. 2017;3:e000471. PMID:29081987,                    DOI:10.1136\/rmdopen-2017-000471","DOI":"10.1136\/rmdopen-2017-000471"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Paulissen SM, van Hamburg JP, Davelaar N,                    Asmawidjaja PS, Hazes JM, Lubberts E. Synovial fibroblasts directly induce Th17                    pathogenicity via the cyclooxygenase\/prostaglandin E2 pathway, independent of                    IL-23. J Immunol (Baltimore, Md: 1950). 2013;191:1364-72.","DOI":"10.4049\/jimmunol.1300274"},{"key":"4","doi-asserted-by":"publisher","unstructured":"4. Falconer J, Murphy AN, Young SP, Clark                    AR, Tiziani S, Guma M, et al. Review: Synovial Cell Metabolism and Chronic                    Inflammation in Rheumatoid Arthritis. Arthritis Rheumatol. 2018;70:984-99.                    PMID:29579371, DOI:10.1002\/art.40504","DOI":"10.1002\/art.40504"},{"key":"5","doi-asserted-by":"publisher","unstructured":"5. Hashizume M, Hayakawa N, Mihara M. IL-6                    trans-signalling directly induces RANKL on fibroblast-like synovial cells and is                    involved in RANKL induction by TNF- and IL-17. Rheumatology. 2008;47:1635-40.                    PMID:18786965, DOI:10.1093\/rheumatology\/ken363","DOI":"10.1093\/rheumatology\/ken363"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Sano H. The Role of Lipid Mediators in                    the Pathogenesis of Rheumatoid Arthritis. Inflamm Regen.                    2011;31:151-6.","DOI":"10.2492\/inflammregen.31.151"},{"key":"7","doi-asserted-by":"publisher","unstructured":"7. Yoon HY, Lee EG, Lee H, Cho IJ, Choi YJ,                    Sung MS, et al. Kaempferol inhibits IL-1\u03b2-induced proliferation of rheumatoid                    arthritis synovial fibroblasts and the production of COX-2, PGE2 and MMPs. Int J                    Mol Med. 2013;32:971-7. PMID:23934131,                    DOI:10.3892\/ijmm.2013.1468","DOI":"10.3892\/ijmm.2013.1468"},{"key":"8","doi-asserted-by":"publisher","unstructured":"8. Frederick ED, Hausburg MA, Thomas GW,                    Rael LT, Brody E, Bar-Or D. The low molecular weight fraction of human serum                    albumin upregulates COX2, prostaglandin E2, and prostaglandin D2 under                    inflammatory conditions in osteoarthritic knee synovial fibroblasts. Biochem                    Biophys Rep. 2016;8:68-74. PMID:28955943,                    DOI:10.1016\/j.bbrep.2016.08.015","DOI":"10.1016\/j.bbrep.2016.08.015"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Pillinger MH, Rosenthal PB, Tolani SN,                    Apsel B, Dinsell V, Greenberg J, et al. Cyclooxygenase-2-derived E                    prostaglandins down-regulate matrix metalloproteinase-1 expression in                    fibroblast-like synoviocytes via inhibition of extracellular signal-regulated                    kinase activation. J Immunol (Baltimore, Md: 1950).                    2003;171:6080-9.","DOI":"10.4049\/jimmunol.171.11.6080"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Dyerberg J, Bang HO, Stoffersen E,                    Moncada S, Vane JR. Eicosapentaenoic acid and prevention of thrombosis and                    atherosclerosis? Lancet. 1978;312:117-9. PMID:78322,                    DOI:10.1016\/S0140-6736(78)91505-2","DOI":"10.1016\/S0140-6736(78)91505-2"},{"key":"11","doi-asserted-by":"publisher","unstructured":"11. Fredman G, Serhan CN. Specialized                    proresolving mediator targets for RvE1 and RvD1 in peripheral blood and                    mechanisms of resolution. Biochem J. 2011;437:185-97. PMID:21711247,                    DOI:10.1042\/BJ20110327","DOI":"10.1042\/BJ20110327"},{"key":"12","doi-asserted-by":"publisher","unstructured":"12. Huang D, Zhao Q, Liu H, Guo Y, Xu H.                    PPAR-\u03b1 Agonist WY-14643 Inhibits LPS-Induced Inflammation in Synovial                    Fibroblasts via NF-kB Pathway. J Mol Neurosci. 2016;59:544-53. PMID:27339772,                    DOI:10.1007\/s12031-016-0775-y","DOI":"10.1007\/s12031-016-0775-y"},{"key":"13","doi-asserted-by":"publisher","unstructured":"13. 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Eicosapentaenoic acid and docosapentaenoic acid monoglycerides are more potent                    than docosahexaenoic acid monoglyceride to resolve inflammation in a rheumatoid                    arthritis model. Arthritis Res Ther. 2015;17:142. PMID:26022389,                    DOI:10.1186\/s13075-015-0653-y","DOI":"10.1186\/s13075-015-0653-y"},{"key":"16","doi-asserted-by":"publisher","unstructured":"16. Ohira T, Arita M, Omori K, Recchiuti A,                    Van Dyke TE, Serhan CN. Resolvin E1 receptor activation signals phosphorylation                    and phagocytosis. J Biol Chem. 2010;285:3451-61. PMID:19906641,                    DOI:10.1074\/jbc.M109.044131","DOI":"10.1074\/jbc.M109.044131"},{"key":"17","doi-asserted-by":"publisher","unstructured":"17. Arnardottir HH, Dalli J, Norling LV,                    Colas RA, Perretti M, Serhan CN. Resolvin D3 Is Dysregulated in Arthritis and                    Reduces Arthritic Inflammation. J Immunol (Baltimore, Md: 1950).                    2016;197:2362-8. DOI:10.4049\/jimmunol.1502268","DOI":"10.4049\/jimmunol.1502268"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Marcon R, Bento AF, Dutra RC, Bicca MA,                    Leite DF, Calixto JB. Maresin 1, a proresolving lipid mediator derived from                    omega-3 polyunsaturated fatty acids, exerts protective actions in murine models                    of colitis. J Immunol (Baltimore, Md: 1950). 2013;191:4288-98.","DOI":"10.4049\/jimmunol.1202743"},{"key":"19","doi-asserted-by":"publisher","unstructured":"19. Norling LV, Headland SE, Dalli J,                    Arnardottir HH, Haworth O, Jones HR, et al. Proresolving and                    cartilage-protective actions of resolvin D1 in inflammatory arthritis. JCI                    Insight. 2016;1:e85922. PMID:27158677,                    DOI:10.1172\/jci.insight.85922","DOI":"10.1172\/jci.insight.85922"},{"key":"20","doi-asserted-by":"publisher","unstructured":"20. Sun Q, Wu Y, Zhao F, Wang J. Maresin 1                    inhibits transforming growth factor-\u03b21-induced proliferation, migration and                    differentiation in human lung fibroblasts. Mol Med Rep. 2017;16:1523-9.                    PMID:29067437, DOI:10.3892\/mmr.2017.6711","DOI":"10.3892\/mmr.2017.6711"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Wu MH, Tsai CH, Huang YL, Fong YC, Tang                    CH. Visfatin Promotes IL-6 and TNF-\u03b1 Production in Human Synovial Fibroblasts by                    Repressing miR-199a-5p through ERK, p38 and JNK Signaling Pathways. Int J Mol                    Sci. 2018;19:190. PMID:29316707, DOI:10.3390\/ijms19010190","DOI":"10.3390\/ijms19010190"},{"key":"22","doi-asserted-by":"publisher","unstructured":"22. Gyurko R, Van Dyke TE. The role of                    polyunsaturated \u03c9-3 fatty acid eicosapentaenoic acid-derived resolvin E1 (RvE1)                    in bone preservation. Crit Rev Immunol. 2014;34:347-57. PMID:24941160,                    DOI:10.1615\/CritRevImmunol.2014009982","DOI":"10.1615\/CritRevImmunol.2014009982"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Gao L, Faibish D, Fredman G, Herrera BS,                    Chiang N, Serhan CN, et al. Resolvin E1 and chemokine-like receptor 1 mediate                    bone preservation. J Immunol (Baltimore, Md: 1950). 2013;190:689-94. PMCID:                    PMC3538964","DOI":"10.4049\/jimmunol.1103688"},{"key":"24","doi-asserted-by":"publisher","unstructured":"24. Herrera BS, Ohira T, Gao L, Omori K, Yang                    R, Zhu M, et al. An endogenous regulator of inflammation, resolvin E1, modulates                    osteoclast differentiation and bone resorption. Br J Pharmacol.                    2008;155:1214-23. PMID:18806821, DOI:10.1038\/bjp.2008.367","DOI":"10.1038\/bjp.2008.367"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Funaki Y. Resolvin E1 Inhibits                    Osteoclastogenesis and Bone Resorption by Suppressing IL-17-induced RANKL                    Expression in Osteoblasts and RANKL-induced Osteoclast Differentiation. Yonago                    Acta Med. 2018;61:008-018.","DOI":"10.33160\/yam.2018.03.002"},{"key":"26","doi-asserted-by":"publisher","unstructured":"26. Xu ZZ, Ji RR. Resolvins are potent                    analgesics for arthritic pain. Br J Pharmacol. 2011;164:274-7. PMID:21418190,                    DOI:10.1111\/j.1476-5381.2011.01348.x","DOI":"10.1111\/j.1476-5381.2011.01348.x"},{"key":"27","doi-asserted-by":"publisher","unstructured":"27. Sun W, Ma J, Zhao H, Xiao C, Zhong H,                    Ling H, et al. Resolvin D1 suppresses pannus formation via decreasing connective                    tissue growth factor caused by upregulation of miRNA-146a-5p in rheumatoid                    arthritis. Arthritis Res Ther. 2020;22:61. PMID:32216830,                    DOI:10.1186\/s13075-020-2133-2","DOI":"10.1186\/s13075-020-2133-2"},{"key":"28","doi-asserted-by":"publisher","unstructured":"28. \u00d6zg\u00fcl \u00d6zdemir RB, Soysal G\u00fcnd\u00fcz \u00d6,                    \u00d6zdemir AT, Akg\u00fcl \u00d6. Low levels of pro-resolving lipid mediators lipoxin-A4,                    resolvin-D1 and resolvin-E1 in patients with rheumatoid arthritis. Immunol Lett.                    2020;227:34-40. PMID:32818598, DOI:10.1016\/j.imlet.2020.08.006","DOI":"10.1016\/j.imlet.2020.08.006"},{"key":"29","doi-asserted-by":"publisher","unstructured":"29. Proudman SM, Cleland LG, Metcalf RG,                    Sullivan TR, Spargo LD, James MJ. Plasma n -3 fatty acids and clinical outcomes                    in recent-onset rheumatoid arthritis. Br J Nutr. 2015;114:885-90. PMID:26283657,                    DOI:10.1017\/S0007114515002718","DOI":"10.1017\/S0007114515002718"},{"key":"30","doi-asserted-by":"publisher","unstructured":"30. Proudman SM, James MJ, Spargo LD, Metcalf                    RG, Sullivan TR, Rischmueller M, et al. Fish oil in recent onset rheumatoid                    arthritis: a randomised, double-blind controlled trial within algorithm-based                    drug use. Ann Rheum Dis. 2015;74:89-95. PMID:24081439,                    DOI:10.1136\/annrheumdis-2013-204145","DOI":"10.1136\/annrheumdis-2013-204145"},{"key":"31","doi-asserted-by":"publisher","unstructured":"31. Di Giuseppe D, Crippa A, Orsini N, Wolk                    A. Fish consumption and risk of rheumatoid arthritis: a dose-response                    meta-analysis. Arthritis Res Ther. 2014;16:446. PMID:25267142,                    DOI:10.1186\/s13075-014-0446-8","DOI":"10.1186\/s13075-014-0446-8"},{"key":"32","doi-asserted-by":"publisher","unstructured":"32. Goldberg RJ, Spencer FA, Okolo J, Lessard                    D, Yarzebski J, Gore JM. Retraction notice to \u201cLong-Term Trends (1986-2003)in                    the Use of Coronary Reperfusion Strategies in Patients Hospitalized With Acute                    Myocardial Infarction in Central Massachusetts\u201d [Int. J Cardiol. 131 (2008)                    (83-89)] [Int. J Cardiol. 131 (2008) (83-89)]. Int J Cardiol. 2017;235:207.                    PMID:28342504, DOI:10.1016\/j.ijcard.2014.07.065","DOI":"10.1016\/j.ijcard.2014.07.065"},{"key":"33","doi-asserted-by":"publisher","unstructured":"33. Lee YH, Bae SC, Song GG. Omega-3                    polyunsaturated fatty acids and the treatment of rheumatoid arthritis: a                    meta-analysis. Arch Med Res. 2012;43:356-62. PMID:22835600,                    DOI:10.1016\/j.arcmed.2012.06.011","DOI":"10.1016\/j.arcmed.2012.06.011"},{"key":"34","doi-asserted-by":"publisher","unstructured":"34. Aung T, Halsey J, Kromhout D, Gerstein                    HC, Marchioli R, Tavazzi L, et al.; Omega-3 Treatment Trialists\u2019 Collaboration.                    Associations of Omega-3 Fatty Acid Supplement Use With Cardiovascular Disease                    Risks. JAMA Cardiol. 2018;3:225-34. PMID:29387889,                    DOI:10.1001\/jamacardio.2017.5205","DOI":"10.1001\/jamacardio.2017.5205"},{"key":"35","doi-asserted-by":"publisher","unstructured":"35. Bowman L, Mafham M, Wallendszus K,                    Stevens W, Buck G, Barton J, et al.; ASCEND Study Collaborative Group. Effects                    of Aspirin for Primary Prevention in Persons with Diabetes Mellitus. N Engl J                    Med. 2018;379:1529-39. PMID:30146931, DOI:10.1056\/NEJMoa1804988","DOI":"10.1056\/NEJMoa1804988"},{"key":"36","doi-asserted-by":"publisher","unstructured":"36. Miyazawa K, Mori A, Okudaira H.                    Establishment and characterization of a novel human rheumatoid fibroblast-like                    synoviocyte line, MH7A, immortalized with SV40 T antigen. J Biochem.                    1998;124:1153-62. PMID:9832620,                    DOI:10.1093\/oxfordjournals.jbchem.a022233","DOI":"10.1093\/oxfordjournals.jbchem.a022233"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Yoshihiro Funaki YH, Ryota Okazaki, Akira                    Yamasaki, Yuriko Sueda, Akihiro Yamamoto,, Masaaki Yanai TF, Tomoya Harada,                    Haruhiko Makino and Eiji Shimizu. Resolvin E1 Inhibits Osteoclastogenesis and                    Bone Resorption by Suppressing IL-17-induced RANKL Expression in Osteoblasts and                    RANKL-induced Osteoclast Differentiation. Yonago Acta Med.                    2018;61:008-018.","DOI":"10.33160\/yam.2018.03.002"},{"key":"38","doi-asserted-by":"publisher","unstructured":"38. Cao D, Pi J, Shan Y, Tang Y, Zhou P.                    Anti\u2011inflammatory effect of Resolvin D1 on LPS\u2011treated MG\u201163 cells. Exp Ther                    Med. 2018;16:4283-8. PMID:30402165, DOI:10.3892\/etm.2018.6721","DOI":"10.3892\/etm.2018.6721"},{"key":"39","doi-asserted-by":"publisher","unstructured":"39. Chiang N, Libreros S, Norris PC, de la                    Rosa X, Serhan CN. Maresin 1 activates LGR6 receptor promoting phagocyte                    immunoresolvent functions. J Clin Invest. 2019;129:5294-311. PMID:31657786,                    DOI:10.1172\/JCI129448","DOI":"10.1172\/JCI129448"},{"key":"40","doi-asserted-by":"publisher","unstructured":"40. Kitanaka T, Nakano R, Kitanaka N, Kimura                    T, Okabayashi K, Narita T, et al. JNK activation is essential for activation of                    MEK\/ERK signaling in IL-1\u03b2-induced COX-2 expression in synovial fibroblasts. Sci                    Rep. 2017;7:39914. PMID:28054591, DOI:10.1038\/srep39914","DOI":"10.1038\/srep39914"},{"key":"41","doi-asserted-by":"publisher","unstructured":"41. Benabdoun HA, Kulbay M, Rondon EP,                    Valli\u00e8res F, Shi Q, Fernandes J, et al. In vitro and in vivo assessment of the                    proresolutive and antiresorptive actions of resolvin D1: relevance to arthritis.                    Arthritis Res Ther. 2019;21:72. PMID:30867044,                    DOI:10.1186\/s13075-019-1852-8","DOI":"10.1186\/s13075-019-1852-8"},{"key":"42","doi-asserted-by":"publisher","unstructured":"42. Im DS. Omega-3 fatty acids in                    anti-inflammation (pro-resolution) and GPCRs. Prog Lipid Res. 2012;51:232-7.                    PMID:22542696, DOI:10.1016\/j.plipres.2012.02.003","DOI":"10.1016\/j.plipres.2012.02.003"},{"key":"43","doi-asserted-by":"publisher","unstructured":"43. Cash JL, Norling LV, Perretti M.                    Resolution of inflammation: targeting GPCRs that interact with lipids and                    peptides. Drug Discov Today. 2014;19:1186-92. PMID:24993159,                    DOI:10.1016\/j.drudis.2014.06.023","DOI":"10.1016\/j.drudis.2014.06.023"},{"key":"44","doi-asserted-by":"publisher","unstructured":"44. Tang D, Fu G, Li W, Sun P, Loughran PA,                    Deng M, et al. Maresin 1 protects the liver against ischemia\/reperfusion injury                    via the ALXR\/Akt signaling pathway. Mol Med. 2021;27:18. PMID:33632134,                    DOI:10.1186\/s10020-021-00280-9","DOI":"10.1186\/s10020-021-00280-9"},{"key":"45","doi-asserted-by":"publisher","unstructured":"45. Hou SM, Hou CH, Liu JF. CX3CL1 promotes                    MMP-3 production via the CX3CR1, c-Raf, MEK, ERK, and NF-\u03baB signaling pathway in                    osteoarthritis synovial fibroblasts. Arthritis Res Ther. 2017;19:282.                    PMID:29268768, DOI:10.1186\/s13075-017-1487-6","DOI":"10.1186\/s13075-017-1487-6"},{"key":"46","doi-asserted-by":"publisher","unstructured":"46. Huber LC, Distler O, Tarner I, Gay RE,                    Gay S, Pap T. Synovial fibroblasts: key players in rheumatoid arthritis.                    Rheumatology. 2006;45:669-75. PMID:16567358,                    DOI:10.1093\/rheumatology\/kel065","DOI":"10.1093\/rheumatology\/kel065"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47. Jones DS, Jenney AP, Joughin BA, Sorger                    PK, Lauffenburger DA. Inflammatory but not mitogenic contexts prime synovial                    fibroblasts for compensatory signaling responses to p38 inhibition. Sci Signal.                    2018;11:eaal1601. PMID:29511118, DOI:10.1126\/scisignal.aal1601","DOI":"10.1126\/scisignal.aal1601"},{"key":"48","doi-asserted-by":"publisher","unstructured":"48. Julovi SM, Shen K, McKelvey K, Minhas N,                    March L, Jackson CJ. Activated protein C inhibits proliferation and tumor                    necrosis factor \u03b1-stimulated activation of p38, c-Jun NH2-terminal kinase (JNK)                    and Akt in rheumatoid synovial fibroblasts. Mol Med. 2013;19:324-31.                    PMID:24096826, DOI:10.2119\/molmed.2013.00034","DOI":"10.2119\/molmed.2013.00034"},{"key":"49","doi-asserted-by":"publisher","unstructured":"49. Li F, Dai M, Wu H, Deng R, Fu J, Zhang Z,                    et al. Immunosuppressive Effect of Geniposide on Mitogen-Activated Protein                    Kinase Signalling Pathway and Their Cross-Talk in Fibroblast-Like Synoviocytes                    of Adjuvant Arthritis Rats. Molecules. 2018;23:91. PMID:29301301,                    DOI:10.3390\/molecules23010091","DOI":"10.3390\/molecules23010091"},{"key":"50","doi-asserted-by":"publisher","unstructured":"50. Luan L, Ma Y, Zhang L. HOXD10 silencing                    suppresses human fibroblast\u2011like synoviocyte migration in rheumatoid arthritis                    via downregulation of the p38\/JNK pathway. Exp Ther Med. 2018;16:1621-8.                    PMID:30186380, DOI:10.3892\/etm.2018.6432","DOI":"10.3892\/etm.2018.6432"},{"key":"51","doi-asserted-by":"publisher","unstructured":"51. Namba S, Nakano R, Kitanaka T, Kitanaka                    N, Nakayama T, Sugiya H. ERK2 and JNK1 contribute to TNF-\u03b1-induced IL-8                    expression in synovial fibroblasts. PLoS One. 2017;12:e0182923. PMID:28806729,                    DOI:10.1371\/journal.pone.0182923","DOI":"10.1371\/journal.pone.0182923"},{"key":"52","doi-asserted-by":"publisher","unstructured":"52. de Molon RS, Thurlings RM, Walgreen B,                    Helsen MM, van der Kraan PM, Cirelli JA, et al. Systemic Resolvin E1 (RvE1)                    Treatment Does Not Ameliorate the Severity of Collagen-Induced Arthritis (CIA)                    in Mice: A Randomized, Prospective, and Controlled Proof of Concept Study.                    Mediators Inflamm. 2019;2019:1-14. PMID:31780864,                    DOI:10.1155\/2019\/5689465","DOI":"10.1155\/2019\/5689465"},{"key":"53","doi-asserted-by":"publisher","unstructured":"53. Zauberman A, Zipori D, Krupsky M,                    Ben-Levy R. Stress activated protein kinase p38 is involved in IL-6 induced                    transcriptional activation of STAT3. Oncogene. 1999;18:3886-93. PMID:10445852,                    DOI:10.1038\/sj.onc.1202738","DOI":"10.1038\/sj.onc.1202738"},{"key":"54","doi-asserted-by":"publisher","unstructured":"54. Suzuki M, Tetsuka T, Yoshida S, Watanabe                    N, Kobayashi M, Matsui N, et al. The role of p38 mitogen-activated protein                    kinase in IL-6 and IL-8 production from the TNF-\u03b1- or IL-1\u03b2-stimulated                    rheumatoid synovial fibroblasts. FEBS Lett. 2000;465:23-7. PMID:10620700,                    DOI:10.1016\/S0014-5793(99)01717-2","DOI":"10.1016\/S0014-5793(99)01717-2"},{"key":"55","doi-asserted-by":"publisher","unstructured":"55. Nishikai-Yan Shen T, Kanazawa S, Kado M,                    Okada K, Luo L, Hayashi A, et al. Interleukin-6 stimulates Akt and p38 MAPK                    phosphorylation and fibroblast migration in non-diabetic but not diabetic mice.                    PLoS One. 2017;12:e0178232. PMID:28542434,                    DOI:10.1371\/journal.pone.0178232","DOI":"10.1371\/journal.pone.0178232"},{"key":"56","doi-asserted-by":"publisher","unstructured":"56. Kaneko K, Miyabe Y, Takayasu A, Fukuda S,                    Miyabe C, Ebisawa M, et al. Chemerin activates fibroblast-like synoviocytes in                    patients with rheumatoid arthritis. Arthritis Res Ther. 2011;13:R158.                    PMID:21959042, DOI:10.1186\/ar3475","DOI":"10.1186\/ar3475"},{"key":"57","doi-asserted-by":"publisher","unstructured":"57. Mariani F, Roncucci L. Chemerin\/chemR23                    axis in inflammation onset and resolution. Inflamm Res. 2015;64:85-95.                    PMID:25548799, DOI:10.1007\/s00011-014-0792-7","DOI":"10.1007\/s00011-014-0792-7"},{"key":"58","doi-asserted-by":"publisher","unstructured":"58. Maderna P, Cottell DC, Toivonen T, Dufton                    N, Dalli J, Perretti M, et al. FPR2\/ALX receptor expression and internalization                    are critical for lipoxin A 4 and annexin\u2010derived peptide\u2010stimulated                    phagocytosis. FASEB J. 2010;24:4240-9. PMID:20570963,                    DOI:10.1096\/fj.10-159913","DOI":"10.1096\/fj.10-159913"},{"key":"59","doi-asserted-by":"publisher","unstructured":"59. Hodges RR, Li D, Shatos MA, Bair JA,                    Lippestad M, Serhan CN, et al. Lipoxin A4 activates ALX\/FPR2 receptor to                    regulate conjunctival goblet cell secretion. Mucosal Immunol. 2017;10:46-57.                    PMID:27072607, DOI:10.1038\/mi.2016.33","DOI":"10.1038\/mi.2016.33"},{"key":"60","doi-asserted-by":"publisher","unstructured":"60. Im DS. Maresin-1 resolution with ROR\u03b1 and                    LGR6. Prog Lipid Res. 2020;78:101034. PMID:32360520,                    DOI:10.1016\/j.plipres.2020.101034","DOI":"10.1016\/j.plipres.2020.101034"},{"key":"61","doi-asserted-by":"publisher","unstructured":"61. Connor AM, Mahomed N, Gandhi R, Keystone                    EC, Berger SA. TNF\u03b1 modulates protein degradation pathways in rheumatoid                    arthritis synovial fibroblasts. Arthritis Res Ther. 2012;14:R62. PMID:22417670,                    DOI:10.1186\/ar3778","DOI":"10.1186\/ar3778"},{"key":"62","doi-asserted-by":"publisher","unstructured":"62. Zhang Y, Wang S, Dong H, Yi X, Zhang J,                    Liu X, et al. LAIR-1 shedding from human fibroblast-like synoviocytes in                    rheumatoid arthritis following TNF-\u03b1 stimulation. Clin Exp Immunol.                    2018;192:193-205. PMID:29328500, DOI:10.1111\/cei.13100","DOI":"10.1111\/cei.13100"},{"key":"63","doi-asserted-by":"publisher","unstructured":"63. Perretti M, Cooper D, Dalli J, Norling                    LV. Immune resolution mechanisms in inflammatory arthritis. Nat Rev Rheumatol.                    2017;13:87-99. 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