{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T05:04:26Z","timestamp":1771650266757,"version":"3.50.1"},"reference-count":44,"publisher":"Tottori University Faculty of Medicine","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Yonago Acta Med."],"published-print":{"date-parts":[[2026]]},"DOI":"10.33160\/yam.2026.02.009","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T22:09:04Z","timestamp":1769206144000},"page":"78-87","source":"Crossref","is-referenced-by-count":0,"title":["Near-End-of-Life Trajectory in Patients with Advanced Lung Cancer"],"prefix":"10.33160","volume":"69","author":[{"given":"Naoki","family":"Kinoshita","sequence":"first","affiliation":[{"name":"Division of Respiratory Medicine and Rheumatology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago 683-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhiro","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, NHO Yonago Medical Center, Yonago 683-0006, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Ikeuchi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, NHO Yonago Medical Center, Yonago 683-0006, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Touge","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, NHO Yonago Medical Center, Yonago 683-0006, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuyuki","family":"Tomita","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, NHO Yonago Medical Center, Yonago 683-0006, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine and Rheumatology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago 683-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18656","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Lunney JR, Lynn J, Foley DJ, Lipson S, Guralnik JM. Patterns of functional decline at the end of life. JAMA. 2003;289:2387-92. PMID:12746362, DOI:10.1001\/jama.289.18.2387","DOI":"10.1001\/jama.289.18.2387"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Boyd K, Murray SA. Recognising and managing key transitions in end of life care. BMJ. 2010;341:c4863. PMID:20847023, DOI:10.1136\/bmj.c4863","DOI":"10.1136\/bmj.c4863"},{"key":"3","doi-asserted-by":"publisher","unstructured":"3. Teno JM, Weitzen S, Fennell ML, Mor V. Dying trajectory in the last year of life: does cancer trajectory fit other diseases? J Palliat Med. 2001;4:457-64. PMID:11798477, DOI:10.1089\/109662101753381593","DOI":"10.1089\/109662101753381593"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Murray SA, Kendall M, Boyd K, Sheikh A. Illness trajectories and palliative care. BMJ. 2005;330:1007-11. PMID:15860828, DOI:10.1136\/bmj.330.7498.1007","DOI":"10.1136\/bmj.330.7498.1007"},{"key":"5","doi-asserted-by":"publisher","unstructured":"5. Morris JN, Sherwood S. Quality of life of cancer patients at different stages in the disease trajectory. J Chronic Dis. 1987;40:545-53. PMID:3597658, DOI:10.1016\/0021-9681(87)90012-9","DOI":"10.1016\/0021-9681(87)90012-9"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Earle CC, Neville BA, Landrum MB, Ayanian JZ, Block SD, Weeks JC. Trends in the aggressiveness of cancer care near the end of life. J Clin Oncol. 2004;22:315-21. PMID:14722041, DOI:10.1200\/JCO.2004.08.136","DOI":"10.1200\/JCO.2004.08.136"},{"key":"7","doi-asserted-by":"publisher","unstructured":"7. Huang J, Boyd C, Tyldesley S, Zhang-Salomons J, Groome PA, Mackillop WJ. Time spent in hospital in the last six months of life in patients who died of cancer in Ontario. J Clin Oncol. 2002;20:1584-92. PMID:11896108, DOI:10.1200\/JCO.2002.20.6.1584","DOI":"10.1200\/JCO.2002.20.6.1584"},{"key":"8","doi-asserted-by":"publisher","unstructured":"8. Barbera L, Paszat L, Charter C. Indicators of poor quality end-of-life cancer care in Ontario. J Palliat Care. 2006;22:12-7. PMID:16689410, DOI:10.1177\/082585970602200103","DOI":"10.1177\/082585970602200103"},{"key":"9","doi-asserted-by":"publisher","unstructured":"9. Wie GA, Cho YA, Kim SY, Kim SM, Bae JM, Joung H. Prevalence and risk factors of malnutrition among cancer patients according to tumor location and stage in the National Cancer Center in Korea. Nutrition. 2010;26:263-8. PMID:19665873, DOI:10.1016\/j.nut.2009.04.013","DOI":"10.1016\/j.nut.2009.04.013"},{"key":"10","doi-asserted-by":"publisher","unstructured":"10. Pressoir M, Desn\u00e9 S, Berchery D, Rossignol G, Poiree B, Meslier M, et al. Prevalence, risk factors and clinical implications of malnutrition in French Comprehensive Cancer Centres. Br J Cancer. 2010;102:966-71. PMID:20160725, DOI:10.1038\/sj.bjc.6605578","DOI":"10.1038\/sj.bjc.6605578"},{"key":"11","doi-asserted-by":"publisher","unstructured":"11. Aaldriks AA, van der Geest LGM, Giltay EJ, le Cessie S, Portielje JEA, Tanis BC, et al. Frailty and malnutrition predictive of mortality risk in older patients with advanced colorectal cancer receiving chemotherapy. J Geriatr Oncol. 2013;4:218-26. PMID:24070460, DOI:10.1016\/j.jgo.2013.04.001","DOI":"10.1016\/j.jgo.2013.04.001"},{"key":"12","doi-asserted-by":"publisher","unstructured":"12. Nikoletti S, Porock D, Kristjanson LJ, Medigovich K, Pedler P, Smith M. Performance status assessment in home hospice patients using a modified form of the Karnofsky Performance Status Scale. J Palliat Med. 2000;3:301-11. PMID:15859671, DOI:10.1089\/jpm.2000.3.301","DOI":"10.1089\/jpm.2000.3.301"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Mor V, Laliberte L, Morris JN, Wiemann M. The Karnofsky performance status scale: an examination of its reliability and validity in a research setting. Cancer. 1984;53:2002-7. PMID:6704925, DOI:10.1002\/1097-0142(19840501)53:9%3c2002::AID-CNCR2820530933%3e3.0.CO;2-W","DOI":"10.1002\/1097-0142(19840501)53:9<2002::AID-CNCR2820530933>3.0.CO;2-W"},{"key":"14","doi-asserted-by":"publisher","unstructured":"14. Jang RW, Caraiscos VB, Swami N, Banerjee S, Mak E, Kaya E, et al. Simple prognostic model for patients with advanced cancer based on performance status. J Oncol Pract. 2014;10:e335-41. PMID:25118208, DOI:10.1200\/JOP.2014.001457","DOI":"10.1200\/JOP.2014.001457"},{"key":"15","doi-asserted-by":"publisher","unstructured":"15. Masel EK, Schur S, Nemecek R, Mayrhofer M, Huber P, Adamidis F, et al. Palliative care units in lung cancer in the real-world setting: a single institution\u2019s experience and its implications. Ann Palliat Med. 2017;6:6-13. PMID:27701880, DOI:10.21037\/apm.2016.08.06","DOI":"10.21037\/apm.2016.08.06"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Glare P, Virik K, Jones M, Hudson M, Eychmuller S, Simes J, et al. A systematic review of physicians\u2019 survival predictions in terminally ill cancer patients. BMJ. 2003;327:195-8. PMID:12881260, DOI:10.1136\/bmj.327.7408.195","DOI":"10.1136\/bmj.327.7408.195"},{"key":"17","doi-asserted-by":"publisher","unstructured":"17. van de Schoot R, Broere JJ, Perryck KH, Zondervan-Zwijnenburg M, van Loey NE. Analyzing small data sets using Bayesian estimation: the case of posttraumatic stress symptoms following mechanical ventilation in burn survivors. Eur J Psychotraumatol. 2015;6:25216. PMID:25765534, DOI:10.3402\/ejpt.v6.25216","DOI":"10.3402\/ejpt.v6.25216"},{"key":"18","doi-asserted-by":"publisher","unstructured":"18. Gannon MA, de Bragan\u00e7a Pereira CA, Polpo A. Blending Bayesian and classical tools to define optimal sample-size-dependent significance levels. Am Stat. 2019;73 sup1:213-22. .DOI:10.1080\/00031305.2018.1518268","DOI":"10.1080\/00031305.2018.1518268"},{"key":"19","doi-asserted-by":"publisher","unstructured":"19. Anderson F, Downing GM, Hill J, Casorso L, Lerch N. Palliative performance scale (PPS): a new tool. J Palliat Care. 1996;12:5-11. PMID:8857241, DOI:10.1177\/082585979601200102","DOI":"10.1177\/082585979601200102"},{"key":"20","unstructured":"20. Karnofsky DA, Burchenal JH, MacLeod C. The clinical evaluation of chemotherapeutic agents in cancer evaluation of chemotherapeutic Agents 191\u2013205. New York: Columbia University Press; 1949."},{"key":"21","doi-asserted-by":"publisher","unstructured":"21. Stone CA, Tiernan E, Dooley BA. Prospective validation of the palliative prognostic index in patients with cancer. J Pain Symptom Manage. 2008;35:617-22. PMID:18261876, DOI:10.1016\/j.jpainsymman.2007.07.006","DOI":"10.1016\/j.jpainsymman.2007.07.006"},{"key":"22","doi-asserted-by":"publisher","unstructured":"22. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Series B Stat Methodol. 1995;57:289-300. DOI:10.1111\/j.2517-6161.1995.tb02031.x","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"23","unstructured":"23. Brilleman SL, El\u00e7i EE, Novik JB, et al. Bayesian survival analysis using the rstanarm R package. Monash University, Melbourne., Australia., A. Bayer. arXiv. Computation. Medicine. New York: Berlin, H Germany, Generable Inc., Usa less published 22 Febr 2020 Computer Science."},{"key":"24","unstructured":"24. Watanabe S. Asymptotic equivalence of Bayes cross validation and Widely Applicable Information Criterion in singular learning theory. J Mach Learn Res. 2010;11:3571-94."},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Gelman A, Hill J. Data analysis using regression and multilevel\/hierarchical models. New York: Cambridge University Press; 2007.","DOI":"10.32614\/CRAN.package.arm"},{"key":"26","doi-asserted-by":"publisher","unstructured":"27. Non-small Cell Lung Cancer Collaborative Group. Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomised clinical trials. BMJ. 1995;311:899-909. PMID:7580546, DOI:10.1136\/bmj.311.7010.899","DOI":"10.1136\/bmj.311.7010.899"},{"key":"27","doi-asserted-by":"publisher","unstructured":"28. Spiro SG, Rudd RM, Souhami RL, Brown J, Fairlamb DJ, Gower NH, et al.; Big Lung Trial participants. Chemotherapy versus supportive care in advanced non-small cell lung cancer: improved survival without detriment to quality of life. Thorax. 2004;59:828-36. PMID:15454647, DOI:10.1136\/thx.2003.020164","DOI":"10.1136\/thx.2003.020164"},{"key":"28","doi-asserted-by":"crossref","unstructured":"29. Fenchel K, Sellmann L, Dempke WCM. Overall survival in non-small cell lung cancer-what is clinically meaningful? Transl Lung Cancer Res. 2016;5:115-9. PMID:26958505, DOI:10.3978\/j.issn.2218-6751.2016.01.06","DOI":"10.21037\/tlcr.2016.07.01"},{"key":"29","doi-asserted-by":"publisher","unstructured":"30. Costantini M, Beccaro M, Higginson IJ. Cancer Trajectories at the End of Life: is there an effect of age and gender? BMC Cancer. 2008;8:127. PMID:18454854, DOI:10.1186\/1471-2407-8-127","DOI":"10.1186\/1471-2407-8-127"},{"key":"30","doi-asserted-by":"publisher","unstructured":"31. J\u00f3\u017awiak K, Nguyen VH, Sollfrank L, Linn SC, Hauptmann M. Cox proportional hazards regression in small studies of predictive biomarkers. Sci Rep. 2024;14:14232. PMID:38902269, DOI:10.1038\/s41598-024-64573-9","DOI":"10.1038\/s41598-024-64573-9"},{"key":"31","doi-asserted-by":"publisher","unstructured":"32. Sadia F, Hossain SS. Contrast of Bayesian and classical sample size determination. J Mod Appl Stat Methods. 2014;13:420-31. DOI:10.22237\/jmasm\/1414815720","DOI":"10.22237\/jmasm\/1414815720"},{"key":"32","doi-asserted-by":"publisher","unstructured":"33. Geraci JM, Tsang W, Valdres RV, Escalante CP. Progressive disease in patients with cancer presenting to an emergency room with acute symptoms predicts short-term mortality. Support Care Cancer. 2006;14:1038-45. PMID:16572312, DOI:10.1007\/s00520-006-0053-6","DOI":"10.1007\/s00520-006-0053-6"},{"key":"33","doi-asserted-by":"publisher","unstructured":"34. Escalante CP, Martin CG, Elting LS, Price KJ, Manzullo EF, Weiser MA, et al. Identifying risk factors for imminent death in cancer patients with acute dyspnea. J Pain Symptom Manage. 2000;20:318-25. PMID:11068153, DOI:10.1016\/S0885-3924(00)00193-7","DOI":"10.1016\/S0885-3924(00)00193-7"},{"key":"34","doi-asserted-by":"crossref","unstructured":"35. Vigan\u00f2 A, Dorgan M, Bruera E, Suarez-Almazor ME. The relative accuracy of the clinical estimation of the duration of life for patients with end of life cancer. Cancer. 1999;86:170-6. PMID:10391577, DOI:10.1002\/(SICI)1097-0142(19990701)86:1%3c170::AID-CNCR23%3e3.0.CO;2-S","DOI":"10.1002\/(SICI)1097-0142(19990701)86:1<170::AID-CNCR23>3.0.CO;2-S"},{"key":"35","doi-asserted-by":"publisher","unstructured":"36. Firat S, Byhardt RW, Gore E; Radiation Therapy Oncology Group. Comorbidity and Karnofksy performance score are independent prognostic factors in stage III non-small-cell lung cancer: an institutional analysis of patients treated on four RTOG studies. Int J Radiat Oncol Biol Phys. 2002;54:357-64. PMID:12243808, DOI:10.1016\/S0360-3016(02)02939-5","DOI":"10.1016\/S0360-3016(02)02939-5"},{"key":"36","doi-asserted-by":"publisher","unstructured":"37. Trufelli DC, Moraes TV, Lima AAPR, Giglio AD. Epidemiological profile and prognostic factors in patients with lung cancer. Rev Assoc Med Bras (1992). S\u00e3o Paulo 62. 2016;62:428-33. , PMID: 27656852.DOI:10.1590\/1806-9282.62.05.428","DOI":"10.1590\/1806-9282.62.05.428"},{"key":"37","doi-asserted-by":"publisher","unstructured":"38. Morita T, Tsunoda J, Inoue S, Chihara S. The Palliative Prognostic Index: a scoring system for survival prediction of terminally ill cancer patients. Support Care Cancer. 1999;7:128-33. PMID:10335930, DOI:10.1007\/s005200050242","DOI":"10.1007\/s005200050242"},{"key":"38","doi-asserted-by":"crossref","unstructured":"39. Takai E, Yano T, Iguchi H, Fukuyama Y, Yokoyama H, Asoh H, et al. Tumor-induced hypercalcemia and parathyroid hormone-related protein in lung carcinoma. Cancer. 1996;78:1384-7. PMID:8839542, DOI:10.1002\/(SICI)1097-0142(19961001)78:7%3c1384::AID-CNCR3%3e3.0.CO;2-L","DOI":"10.1002\/(SICI)1097-0142(19961001)78:7<1384::AID-CNCR3>3.0.CO;2-L"},{"key":"39","doi-asserted-by":"publisher","unstructured":"40. Bender RA, Hansen H. Hypercalcemia in bronchogenic carcinoma. A prospective study of 200 patients. Ann Intern Med. 1974;80:205-8. PMID:4359740, DOI:10.7326\/0003-4819-80-2-205","DOI":"10.7326\/0003-4819-80-2-205"},{"key":"40","doi-asserted-by":"publisher","unstructured":"41. Mousseaux C, Dupont A, Rafat C, Ekpe K, Ghrenassia E, Kerhuel L, et al. Epidemiology, clinical features, and management of severe hypercalcemia in critically ill patients. Ann Intensive Care. 2019;9:133. PMID:31776814, DOI:10.1186\/s13613-019-0606-8","DOI":"10.1186\/s13613-019-0606-8"},{"key":"41","doi-asserted-by":"publisher","unstructured":"42. Wright JD, Tergas AI, Ananth CV, Burke WM, Hou JY, Chen L, et al. Quality and outcomes of treatment of hypercalcemia of malignancy. Cancer Invest. 2015;33:331-9. PMID:26068056, DOI:10.3109\/07357907.2015.1047506","DOI":"10.3109\/07357907.2015.1047506"},{"key":"42","doi-asserted-by":"publisher","unstructured":"43. Yoon SJ, Choi SE, LeBlanc TW, Suh SY. Palliative performance scale score at 1 week after palliative care unit admission is more useful for survival prediction in patients with advanced cancer in South Korea. Am J Hosp Palliat Care. 2018;35:1168-73. PMID:29660991, DOI:10.1177\/1049909118770604","DOI":"10.1177\/1049909118770604"},{"key":"43","doi-asserted-by":"publisher","unstructured":"44. Romano AM, Gade KE, Nielsen G, Havard R, Harrison JH, Jr, Barclay J, et al. Early palliative care reduces end\u2010of\u2010life intensive care unit (ICU) use but not ICU course in patients with advanced cancer. Oncologist. 2017;22:318-23. PMID:28220023, DOI:10.1634\/theoncologist.2016-0227","DOI":"10.1634\/theoncologist.2016-0227"},{"key":"44","doi-asserted-by":"publisher","unstructured":"45. Cui J, Tan L, Fang P, An Z, Du J, Yu L. Prediction of survival time in advanced lung cancer: a retrospective study in home-based palliative care unit. Am J Hosp Palliat Care. 2023;40:271-9. PMID:35576493, DOI:10.1177\/10499091221100501","DOI":"10.1177\/10499091221100501"}],"container-title":["Yonago Acta Medica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/yam\/69\/1\/69_2026.02.009\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T04:10:49Z","timestamp":1771647049000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/yam\/69\/1\/69_2026.02.009\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.33160\/yam.2026.02.009","relation":{},"ISSN":["1346-8049"],"issn-type":[{"value":"1346-8049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"2026.02.009"}}