{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T09:36:04Z","timestamp":1777109764064,"version":"3.51.4"},"reference-count":180,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,1,12]],"date-time":"2015-01-12T00:00:00Z","timestamp":1421020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CA A Cancer J Clinicians"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.wileyhealthlearning.com\/acs.aspx\">Answer questions and earn CME\/CNE<\/jats:ext-link><\/jats:p><jats:p>The management of squamous cell carcinomas of the anal canal has evolved from surgery as first\u2010line treatment to curative chemoradiation, with surgery reserved for salvage. Significant progress has been made in understanding how to most effectively deliver chemotherapy and reduce toxicity through advancements in radiation delivery. The purpose of this article is to review the multimodality approach to the diagnosis and management of anal cancer based on a review of the published data and in light of available guidelines. <jats:bold>CA Cancer J Clin 2015;65: 139\u2013162. \u00a9 2015 American Cancer Society.<\/jats:bold><\/jats:p>","DOI":"10.3322\/caac.21259","type":"journal-article","created":{"date-parts":[[2015,1,12]],"date-time":"2015-01-12T11:54:07Z","timestamp":1421063647000},"page":"139-162","source":"Crossref","is-referenced-by-count":67,"title":["Anal cancer: Current standards in care and recent changes in practice"],"prefix":"10.3322","volume":"65","author":[{"given":"Ravi","family":"Shridhar","sequence":"first","affiliation":[{"name":"Associate Professor, Department of Radiation Oncology Moffitt Cancer Center Tampa FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Shibata","sequence":"additional","affiliation":[{"name":"Professor, Department of Gastrointestinal Oncology Moffitt Cancer Center Tampa FL"},{"name":"Professor, Department of Cancer Epidemiology Moffitt Cancer Center Tampa FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Chan","sequence":"additional","affiliation":[{"name":"Associate Professor, Department Medical Oncology Vanderbilt University Nashville TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles R.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Professor and Chair, Department of Radiation Medicine Oregon Health and Sciences University Portland OR"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21208"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.45.2524"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990415)85:8<1686::AID-CNCR7>3.0.CO;2-7"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(02)00057-9"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.LGT200570"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28431"},{"key":"e_1_2_10_8_1","volume-title":"NCCN Guidelines for Anal Carcinoma. Version 2.2014","author":"National Comprehensive Cancer Network (NCCN)","year":"2014"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.12-5-524"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198710153171601"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20365"},{"key":"e_1_2_10_12_1","first-page":"1","article-title":"Human papillomaviruses","volume":"90","author":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans","year":"2007","journal-title":"IARC Monogr Eval Carcinog Risks Hum"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199711063371904"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e31827ed372"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21167"},{"key":"e_1_2_10_16_1","first-page":"611","article-title":"Cancers of the anogenital region in renal transplant recipients","volume":"58","author":"Penn I","year":"1986","journal-title":"Analysis of 65 cases. Cancer"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(18)30422-4"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042560-199804010-00004"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042560-199804010-00005"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12339"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2004.tb00456.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70080-3"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djs371"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir1012"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70282-7"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.44.5486"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3182968fa7"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200412150-00004"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32835935b3"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116270"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2013.0358"},{"issue":"3","key":"e_1_2_10_32_1","first-page":"S35","article-title":"Anal cancer and screening guidelines for human papillomavirus in men","volume":"111","author":"Ortoski RA","year":"2011","journal-title":"J Am Osteopath Assoc"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-007-0262-4"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-008-9233-4"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/0969141314522454"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909537"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1010971"},{"key":"e_1_2_10_38_1","volume-title":"World Health Organization Classification of Human Tumours of the Digestive System","author":"Bosman FT","year":"2010"},{"key":"e_1_2_10_39_1","unstructured":"PalefskyJM CranstonRD.Anal squamous intraepithelial lesions: diagnosis screening prevention and treatment [serial online; published online 2014].UpToDate.com. Accessed on December 10 2014."},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910415)67:8<2038::AID-CNCR2820670805>3.0.CO;2-R"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1159\/000226964"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.16.2114"},{"key":"e_1_2_10_43_1","first-page":"415","article-title":"Molecular virology and epidemiology of human papillomavirus and cervical cancer","volume":"4","author":"Palefsky JM","year":"1995","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e31819eb7f0"},{"key":"e_1_2_10_45_1","first-page":"238","article-title":"Metastases to the lymph nodes in epidermoid carcinoma of the anal canal studied by a clearing technique","volume":"169","author":"Wade DS","year":"1989","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-69-823-632"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010701)92:1<77::AID-CNCR1294>3.0.CO;2-P"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02555448"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.02.010"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.07.035"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu188"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25188"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.5.2040"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2011.011020"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.12.012"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2006.07.033"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2005.05.008"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.01.009"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604897"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i44.6349"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.600"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.04.020"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-1063-7"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04729.x"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08269.x"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.11.1438"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09982.x"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70067-6"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000058"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e318227833e"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840701)54:1<114::AID-CNCR2820540124>3.0.CO;2-P"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840315)53:6<1285::AID-CNCR2820530611>3.0.CO;2-N"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-007-9154-7"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02586980"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(85)90428-0"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)03409-5"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605605"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.9.2527"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.16.1914"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.8085"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70086-X"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.35.4837"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.02.042"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.12.3121"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204082"},{"key":"e_1_2_10_86_1","first-page":"994","article-title":"Enhanced antitumor activity of anti\u2010epidermal growth factor receptor monoclonal antibody IMC\u2010C225 in combination with irinotecan (CPT\u201011) against human colorectal tumor xenografts","volume":"8","author":"Prewett MC","year":"2002","journal-title":"Clin Cancer Res"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-189"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28045"},{"issue":"7","key":"e_1_2_10_89_1","article-title":"Cetuximab plus radiochemotherapy in locally advanced anal cancer: interim results of the French multicenter phase II trial ACCORD16 [abstract]","volume":"29","author":"Deutsch E","year":"2011","journal-title":"J Clin Oncol"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(02)00377-5"},{"key":"e_1_2_10_91_1","first-page":"15(suppl)","article-title":"Phase II study of capecitabine and oxaliplatin with concurrent radiation therapy (XELOX\u2010XRT) for squamous cell carcinoma of the anal canal [abstract]","volume":"27","author":"Eng C","year":"2009","journal-title":"J Clin Oncol"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.06.020"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.2810"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.10.046"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.2348"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(03)00039-X"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(98)00528-8"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.03.060"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(91)90265-6"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2014.04.013"},{"key":"e_1_2_10_101_1","first-page":"39","article-title":"Intensity\u2010modulated radiation therapy versus conventional radiation therapy for squamous cell carcinoma of the anal canal","volume":"6","author":"Chuong M","year":"2013","journal-title":"Gastrointest Cancer Res"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.09.023"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25901"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-7-201"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.02.030"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.0170"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.09.046"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-6-134"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13566-012-0029-8"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.09.030"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2011.09.014"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-7-45"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e31827e52a3"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.01.034"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.03.012"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2008.04.011"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(89)90521-X"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1278-3218(00)88252-9"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2004.06.003"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-012-0402-x"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2012.11.003"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1177\/003591574103400303"},{"key":"e_1_2_10_123_1","first-page":"515","article-title":"The treatment of anal carcinoma by interstitial irradiation","volume":"85","author":"Dalby JE","year":"1961","journal-title":"AJR Am J Roentgenol Radium Ther Nucl Med"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2007.02.152"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.09.034"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2010.10.005"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.03.008"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-006-9221-7"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9491-8"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4908"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2011.01.015"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-008-0208-4"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20014"},{"key":"e_1_2_10_134_1","volume-title":"SEER Cancer Statistics Review, 1975\u20102006","author":"Horner M","year":"2009"},{"key":"e_1_2_10_135_1","first-page":"196","volume-title":"American Cancer Society Atlas of Clinical Oncology: Cancer of the Lower Gastrointestinal Tract","author":"Ryan D","year":"2001"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1159\/000090747"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-009-0103-7"},{"issue":"18","key":"e_1_2_10_138_1","article-title":"A randomized trial of chemoradiation using mitomycin or cisplatin, with or without maintenance cisplatin\/5FU in squamous cell carcinoma of the anus (ACT II) [abstract]","volume":"27","author":"James R","year":"2009","journal-title":"J Clin Oncol"},{"key":"e_1_2_10_139_1","first-page":"861","article-title":"5\u2010Fluorouracile and cisplatinum combination chemotherapy for metastatic squamous\u2010cell anal cancer [article in French]","volume":"86","author":"Faivre C","year":"1999","journal-title":"Bull Cancer"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(89)80702-8"},{"issue":"15","key":"e_1_2_10_141_1","article-title":"The treatment of metastatic squamous cell carcinoma (SCCA) of the anal canal: a single institution experience [abstract]","volume":"26","author":"Pathak P","year":"2008","journal-title":"J Clin Oncol"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1159\/000361051"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010801)92:3<642::AID-CNCR1365>3.0.CO;2-Z"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001622-200007000-00012"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9467-8"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.12.052"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.09.029"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.12.058"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2008.05.001"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(89)90520-8"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i6.895"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.07.687"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.12.027"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.29.1351"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-007-9125-z"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02237294"},{"key":"e_1_2_10_157_1","first-page":"106","article-title":"NCCN Clinical Practice Guidelines in Oncology. Anal carcinoma","volume":"8","author":"Engstrom PF","year":"2010","journal-title":"J Natl Compr Canc Netw"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-007-9093-3"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-010-2175-5"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.scrs.2013.09.008"},{"key":"e_1_2_10_161_1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1037\/0022-006X.57.6.683","article-title":"Controlled prospective longitudinal study of women with cancer: I. Sexual functioning outcomes","volume":"57","author":"Andersen BL","year":"1989","journal-title":"J Consult Clin Psychol"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(99)80458-0"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24906"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2013.770599"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-5-117"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690567"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2010.486411"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.315"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.7372"},{"key":"e_1_2_10_170_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.41.2.121"},{"key":"e_1_2_10_171_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-013-1726-6"},{"key":"e_1_2_10_172_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.57.1.43"},{"key":"e_1_2_10_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prro.2011.12.001"},{"key":"e_1_2_10_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2007.08.011"},{"key":"e_1_2_10_175_1","doi-asserted-by":"publisher","DOI":"10.1159\/000100521"},{"key":"e_1_2_10_176_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e32832b9d76"},{"key":"e_1_2_10_177_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.44.3.407"},{"key":"e_1_2_10_178_1","doi-asserted-by":"publisher","DOI":"10.4045\/tidsskr.10.1417"},{"key":"e_1_2_10_179_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200007000-00020"},{"key":"e_1_2_10_180_1","first-page":"CD005005","article-title":"Hyperbaric oxygen therapy for late radiation tissue injury [serial online]","volume":"3","author":"Bennett MH","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_181_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hch074"}],"container-title":["CA: A Cancer Journal for Clinicians"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3322%2Fcaac.21259","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3322%2Fcaac.21259","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.3322\/caac.21259","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T21:17:44Z","timestamp":1760044664000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.3322\/caac.21259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,12]]},"references-count":180,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.3322\/caac.21259"],"URL":"https:\/\/doi.org\/10.3322\/caac.21259","archive":["Portico"],"relation":{},"ISSN":["0007-9235","1542-4863"],"issn-type":[{"value":"0007-9235","type":"print"},{"value":"1542-4863","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,12]]}}}