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The occurrence of cancer is increasing because of the growth and aging of the population, as well as an increasing prevalence of established risk factors such as smoking, overweight, physical inactivity, and changing reproductive patterns associated with urbanization and economic development. Based on GLOBOCAN estimates, about 14.1 million new cancer cases and 8.2 million deaths occurred in 2012 worldwide. Over the years, the burden has shifted to less developed countries, which currently account for about 57% of cases and 65% of cancer deaths worldwide. Lung cancer is the leading cause of cancer death among males in both more and less developed countries, and has surpassed breast cancer as the leading cause of cancer death among females in more developed countries; breast cancer remains the leading cause of cancer death among females in less developed countries. Other leading causes of cancer death in more developed countries include colorectal cancer among males and females and prostate cancer among males. In less developed countries, liver and stomach cancer among males and cervical cancer among females are also leading causes of cancer death. Although incidence rates for all cancers combined are nearly twice as high in more developed than in less developed countries in both males and females, mortality rates are only 8% to 15% higher in more developed countries. This disparity reflects regional differences in the mix of cancers, which is affected by risk factors and detection practices, and\/or the availability of treatment. Risk factors associated with the leading causes of cancer death include tobacco use (lung, colorectal, stomach, and liver cancer), overweight\/obesity and physical inactivity (breast and colorectal cancer), and infection (liver, stomach, and cervical cancer). A substantial portion of cancer cases and deaths could be prevented by broadly applying effective prevention measures, such as tobacco control, vaccination, and the use of early detection tests.\n                    <jats:bold>CA Cancer J Clin 2015;65: 87\u2013108. \u00a9 2015 American Cancer Society.<\/jats:bold>\n                  <\/jats:p>","DOI":"10.3322\/caac.21262","type":"journal-article","created":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T10:16:52Z","timestamp":1423045012000},"page":"87-108","source":"Crossref","is-referenced-by-count":18809,"title":["Global cancer statistics, 2012"],"prefix":"10.3322","volume":"65","author":[{"given":"Lindsey A.","family":"Torre","sequence":"first","affiliation":[{"name":"Epidemiologist, Surveillance and Health Services Research American Cancer Society Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freddie","family":"Bray","sequence":"additional","affiliation":[{"name":"Head, Section of Cancer Surveillance International Agency for Research on Cancer Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L.","family":"Siegel","sequence":"additional","affiliation":[{"name":"Director of Surveillance Information, Surveillance and Health Services Research American Cancer Society Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Ferlay","sequence":"additional","affiliation":[{"name":"Informatics Officer, Section of Cancer Surveillance International Agency for Research on Cancer Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joannie","family":"Lortet\u2010Tieulent","sequence":"additional","affiliation":[{"name":"Senior Epidemiologist, Surveillance and Health Services Research American Cancer Society Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmedin","family":"Jemal","sequence":"additional","affiliation":[{"name":"Vice President, Surveillance and Health Services Research American Cancer Society Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,4]]},"reference":[{"key":"e_1_2_4_2_1","unstructured":"FerlayJ SoerjomataramI ErvikM et al; International Agency for Research on Cancer. 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