{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:52:51Z","timestamp":1792601571718,"version":"4.5.0"},"reference-count":86,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,5,13]],"date-time":"2016-05-13T00:00:00Z","timestamp":1463097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CA A Cancer J Clinicians"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In 1996, the Board of Directors of the American Cancer Society (ACS) challenged the United States to reduce what looked to be possible peak cancer mortality in 1990 by 50% by the year 2015. This analysis examines the trends in cancer mortality across this 25\u2010year challenge period from 1990 to 2015. In 2015, cancer death rates were 26% lower than in 1990 (32% lower among men and 22% lower among women). The 50% reduction goal was more fully met for the cancer sites for which there was enactment of effective approaches for prevention, early detection, and\/or treatment. Among men, mortality rates dropped for lung cancer by 45%, for colorectal cancer by 47%, and for prostate cancer by 53%. Among women, mortality rates dropped for lung cancer by 8%, for colorectal cancer by 44%, and for breast cancer by 39%. Declines in the death rates of all other cancer sites were substantially smaller (13% among men and 17% among women). The major factors that accounted for these favorable trends were progress in tobacco control and improvements in early detection and treatment. As we embark on new national cancer goals, this recent past experience should teach us that curing the cancer problem will require 2 sets of actions: making new discoveries in cancer therapeutics and more completely applying those discoveries in cancer prevention we have already made.\n                    <jats:bold>CA Cancer J Clin 2016;66:359\u2013369. \u00a9 2016 American Cancer Society.<\/jats:bold>\n                  <\/jats:p>","DOI":"10.3322\/caac.21348","type":"journal-article","created":{"date-parts":[[2016,5,13]],"date-time":"2016-05-13T11:10:22Z","timestamp":1463137822000},"page":"359-369","source":"Crossref","is-referenced-by-count":74,"title":["The American Cancer Society challenge goal to reduce US cancer mortality by 50% between 1990 and 2015: Results and reflections"],"prefix":"10.3322","volume":"66","author":[{"given":"Tim","family":"Byers","sequence":"first","affiliation":[{"name":"Professor of Epidemiology, Colorado School of Public Health University of Colorado Aurora CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard C.","family":"Wender","sequence":"additional","affiliation":[{"name":"Chief Cancer Control Officer, American Cancer Society Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmedin","family":"Jemal","sequence":"additional","affiliation":[{"name":"Vice President,Surveillance and Health Services Research Program American Cancer Society Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold M.","family":"Baskies","sequence":"additional","affiliation":[{"name":"Surgical Oncologist Virtua Surgical Specialists Hainesport NJ and Vice-President of the American Cancer Society Board of Directors, Atlanta, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth E.","family":"Ward","sequence":"additional","affiliation":[{"name":"National Vice\u2010President for Intramural Research American Cancer Society Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otis W.","family":"Brawley","sequence":"additional","affiliation":[{"name":"Chief Medical Officer, American Cancer Society Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,13]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"ACS Challenge Goals for US Cancer Mortality for the Year 2015","author":"American Cancer Society Board of Directors","year":"1996"},{"key":"e_1_2_6_3_1","unstructured":"Centers for Disease Control and Prevention.National Center for Health Statistics Web site.cdc.gov\/nchs. Accessed March 31 2016."},{"key":"e_1_2_6_4_1","unstructured":"National Center for Health Statistics.Health Interview Survey data. Public use data files and documentation.cdc.gov\/nchs\/nhis.htm. Accessed March 31 2016."},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800541"},{"key":"e_1_2_6_6_1","unstructured":"National Center for Health Statistics.National Health and Nutrition Examination Surveys. Public use data files and documentation.cdc.gov\/nchs\/nhanes\/search\/nhanes13_14.aspx. Accessed March 31 2016."},{"issue":"3","key":"e_1_2_6_7_1","first-page":"1","article-title":"State\u2010 and sex\u2010specific prevalence of selected characteristics\u2014Behavioral Risk Factor Surveillance System, 1994 and 1995. Centers for Disease Control and Prevention (CDC) Surveillance Summaries, August 1, 1997","volume":"46","author":"Powell\u2010Griner E","year":"1997","journal-title":"MMWR Morb Mortal Wkly Rep."},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.85.6.840"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11208"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22607"},{"key":"e_1_2_6_11_1","volume-title":"Weight Control and Physical Activity. IARC Handbook of Cancer Prevention","author":"International Agency for Cancer Research (IARC)","year":"2002"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2007.09.008"},{"key":"e_1_2_6_13_1","unstructured":"US Department of Health and Human Services Centers for Disease Control and Prevention CDC).CDC WONDER[online data].wonder.cdc.govAccessed March 31 2016."},{"key":"e_1_2_6_14_1","unstructured":"Centers for Disease Control and Prevention (CDC).1991\u20132013 High School Youth Risk Behavior Survey Data.nccd.cdc.gov\/youthonline\/. Accessed March 31 2016."},{"key":"e_1_2_6_15_1","first-page":"381","article-title":"Tobacco use among middle and high school students\u2014United States, 2011\u20102014","volume":"64","author":"Arrazola RA","year":"2015","journal-title":"MMWR Morb Mortal Wkly Rep."},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2015.09.004"},{"key":"e_1_2_6_17_1","unstructured":"Robert Wood Johnson Foundation Campaign for Tobacco\u2010Free Kids American Cancer Society Cancer Action Network American Heart Association American Lung Association andAmericans for Nonsmokers' Rights.Broken Promises to Our Children: A State\u2010by\u2010State Look at the 1998 State Tobacco Settlement 17 Years Later. December 2015.tobaccofreekids.org\/microsites\/statereport2016\/. Accessed March 31 2016."},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114706"},{"key":"e_1_2_6_19_1","unstructured":"Centers for Disease Control and Prevention (CDC).Detailed Mortality Data From the CDC Behavioral Risk Factor Surveillance System.cdc.gov\/brfss. Accessed March 31 2016."},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1102873"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21172"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.65.8427"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17706-X"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.732"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.3322\/CA.2007.0018"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2008.01796.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-11-0220"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.13.1601"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.06.001"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-15-0082"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050518"},{"key":"e_1_2_6_32_1","first-page":"41","article-title":"Cancer screening\u2010United States, 2010","volume":"61","author":"Centers for Disease Control and Prevention (CDC)","year":"2012","journal-title":"MMWR Morb Mortal Wkly Rep."},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.56.9848"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.55.4139"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.18.1371"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.23.joc60074"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70207-2"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12795"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318265df42"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042098614568300"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr070105"},{"key":"e_1_2_6_42_1","volume-title":"Policy and Action for Cancer Prevention. Food, nutrition, and physical activity: a global perspective","author":"World Cancer Research Fund\/American Institute for Cancer Prevention","year":"2009"},{"key":"e_1_2_6_43_1","unstructured":"World Cancer Research Fund\/American Institute for Cancer Research.Continuous Update Project Report. Food nutrition physical activity and the prevention of breast cancer. Washington DC: American Institute for Cancer Research; 2010.wcrf.org. Accessed March 31 2016."},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21320"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2013.06.001"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1113135"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr500"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20066"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-157-2-201207170-00459"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(02)00439-8"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djt248"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61947-4"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215932"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1437"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-2235"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa1407211"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2011.01464.x"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)62401-6"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-159-5-201309030-00672"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13012"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe1513245"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2014.12.028"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe1415742"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20785"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21219"},{"key":"e_1_2_6_66_1","unstructured":"Social Security Administration.Actuarial Life Table.ssa.gov\/oact\/STATS\/table4c6.html. Accessed April 18 2016."},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21340"},{"key":"e_1_2_6_68_1","first-page":"51","article-title":"Health disparities and cancer: racial disparities in cancer mortality in the United States, 2000\u20132010 [serial online]","volume":"3","author":"O'Keefe EB","year":"2015","journal-title":"Front Public Health."},{"key":"e_1_2_6_69_1","unstructured":"Office of Management and Budget The White House.Revisions to the Standards for the Classification of Federal Data on Race and Ethnicity.whitehouse.gov\/omb\/fedreg_1997standards. Accessed March 31 2015."},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21335"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20876"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23044"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23567"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.10546"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1406586"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29494"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1058040"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005522"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200104053441401"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200690"},{"key":"e_1_2_6_81_1","volume-title":"Cancer Control Objectives for the Nation, 1985\u20132000. National Cancer Institute Monograph no. 2","author":"Greenwald P","year":"1986"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198605083141905"},{"key":"e_1_2_6_83_1","first-page":"637","article-title":"NCI sets goal of eliminating suffering and death due to cancer by 2015","volume":"95","author":"Eschenbach AC","year":"2003","journal-title":"J Natl Med Assoc."},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/95.20.1500"},{"key":"e_1_2_6_85_1","unstructured":"The White House Office of the Press Secretary.Remarks of President Barack Obama\u2014State of the Union Address as Delivered.whitehouse.gov\/the\u2010press\u2010office\/2016\/01\/12\/remarks\u2010president\u2010barack\u2010obama\u2010%E2%80%93\u2010prepared\u2010delivery\u2010state\u2010union\u2010address. Accessed January 12 2016."},{"key":"e_1_2_6_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990815)86:4<715::AID-CNCR22>3.0.CO;2-O"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21990"}],"container-title":["CA: A Cancer Journal for Clinicians"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3322%2Fcaac.21348","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3322%2Fcaac.21348","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.3322\/caac.21348","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T13:36:08Z","timestamp":1762349768000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.3322\/caac.21348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,13]]},"references-count":86,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.3322\/caac.21348"],"URL":"https:\/\/doi.org\/10.3322\/caac.21348","archive":["Portico"],"relation":{},"ISSN":["0007-9235","1542-4863"],"issn-type":[{"value":"0007-9235","type":"print"},{"value":"1542-4863","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,13]]}}}