{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:11:13Z","timestamp":1792192273369,"version":"4.4.0"},"reference-count":138,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T00:00:00Z","timestamp":1466121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CA A Cancer J Clinicians"],"published-print":{"date-parts":[[2016,11,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.wileyhealthlearning.com\/acs.aspx\">Answer questions and earn CME\/CNE<\/jats:ext-link>\n                  <\/jats:p>\n                  <jats:p>\n                    Squamous cell carcinoma (SCC) of the penis is a rare malignancy in the United States, with a significantly higher incidence\u2014up to 20 to 30 times greater\u2014in areas of Africa and South America. This can be explained in part by the significantly greater prevalence of sexually transmitted diseases among high\u2010risk males often having unprotected sex with multiple sexual partners. Human papillomavirus (HPV) has been implicated as the infectious pathway by which several these penile neoplasms originate from precursor lesions. In this regard, a fundamental understanding of HPV in penile carcinogenesis can have meaningful implications in understanding 1) the diagnosis of HPV\u2010related precursor penile lesions, 2) targeting HPV\u2010specific molecular pathways, and 3) cancer prevention. Using vaccination programs not only may improve patient outcomes but also may minimize the need for highly aggressive and often debilitating surgical resection.\n                    <jats:bold>CA Cancer J Clin 2016;66:481\u2013495. \u00a9 2016 American Cancer Society<\/jats:bold>\n                    .\n                  <\/jats:p>","DOI":"10.3322\/caac.21354","type":"journal-article","created":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T12:43:16Z","timestamp":1466167396000},"page":"481-495","source":"Crossref","is-referenced-by-count":52,"title":["Pathophysiological basis of human papillomavirus in penile cancer: Key to prevention and delivery of more effective therapies"],"prefix":"10.3322","volume":"66","author":[{"given":"Philippe E.","family":"Spiess","sequence":"first","affiliation":[{"name":"Associate Member, Department of Genitourinary Oncology Moffitt Cancer Center Tampa 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