{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T11:26:27Z","timestamp":1792322787327,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,27]],"date-time":"2017-01-27T00:00:00Z","timestamp":1485475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CA A Cancer J Clinicians"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.wileyhealthlearning.com\/acs.aspx\">Answer questions and earn CME\/CNE<\/jats:ext-link>\n                  <\/jats:p>\n                  <jats:p>\n                    The recently released eighth edition of the American Joint Committee on Cancer (AJCC) Staging Manual, Head and Neck Section, introduces significant modifications from the prior seventh edition. This article details several of the most significant modifications, and the rationale for the revisions, to alert the reader to evolution of the field. The most significant update creates a separate staging algorithm for high\u2010risk human papillomavirus\u2010associated cancer of the oropharynx, distinguishing it from oropharyngeal cancer with other causes. Other modifications include: the reorganizing of skin cancer (other than melanoma and Merkel cell carcinoma) from a general chapter for the entire body to a head and neck\u2010specific cutaneous malignancies chapter; division of cancer of the pharynx into 3 separate chapters; changes to the tumor (T) categories for oral cavity, skin, and nasopharynx; and the addition of extranodal cancer extension to lymph node category (N) in all but the viral\u2010related cancers and mucosal melanoma. The Head and Neck Task Force worked with colleagues around the world to derive a staging system that reflects ongoing changes in head and neck oncology; it remains user friendly and consistent with the traditional tumor, lymph node, metastasis (TNM) staging paradigm.\n                    <jats:bold>CA Cancer J Clin 2017;67:122\u2013137. \u00a9 2017 American Cancer Society.<\/jats:bold>\n                  <\/jats:p>","DOI":"10.3322\/caac.21389","type":"journal-article","created":{"date-parts":[[2017,1,27]],"date-time":"2017-01-27T11:57:42Z","timestamp":1485518262000},"page":"122-137","source":"Crossref","is-referenced-by-count":1123,"title":["Head and neck cancers\u2014major changes in the American Joint Committee on cancer eighth edition cancer staging manual"],"prefix":"10.3322","volume":"67","author":[{"given":"William M.","family":"Lydiatt","sequence":"first","affiliation":[{"name":"Chair\u2010Elect Department of Surgery Nebraska Methodist Hospital and Clinical Professor of Surgery Creighton University, Omaha, NE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snehal G.","family":"Patel","sequence":"additional","affiliation":[{"name":"Assistant Professor of Surgery, Head and Neck Service, Department of Surgery Memorial Sloan Kettering Cancer Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"O'Sullivan","sequence":"additional","affiliation":[{"name":"Professor, Department of Radiation Oncology, Princess Margaret Cancer Center University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret S.","family":"Brandwein","sequence":"additional","affiliation":[{"name":"Professor and Vice Chair for Clinical Affairs, Department of Pathology and Anatomical Sciences State University of New York (SUNY) at the University at Buffalo Buffalo NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Ridge","sequence":"additional","affiliation":[{"name":"Chief, Head and Neck Surgery Section, Department of Surgical Oncology Fox Chase Cancer Center Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn C.","family":"Migliacci","sequence":"additional","affiliation":[{"name":"Research Project Manager, Head and Neck Service, Department of Surgery Memorial Sloan Kettering Cancer Center New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley M.","family":"Loomis","sequence":"additional","affiliation":[{"name":"Statistician, National Cancer Data Base American College of Surgeons Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jatin P.","family":"Shah","sequence":"additional","affiliation":[{"name":"Chief, Head and Neck Service, Department of Surgery Memorial Sloan Kettering Cancer Center New York NY."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,27]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-88441-7"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-40618-3"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.1087"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21021"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c1439"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn025"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.4596"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-04-0551"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.29.2904"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912217"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318253a2d1"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.91"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21974"},{"key":"e_1_2_14_15_1","unstructured":"PfisterDG SpencerS BrizelDM et al.National Comprehensive Center Network. 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