{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:42:00Z","timestamp":1790379720821,"version":"4.1.0"},"reference-count":189,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T00:00:00Z","timestamp":1499299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30CA016672"],"award-info":[{"award-number":["P30CA016672"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CA A Cancer J Clinicians"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.wileyhealthlearning.com\/acs.aspx\">Answer questions and earn CME\/CNE<\/jats:ext-link>\n                  <\/jats:p>\n                  <jats:p>\n                    Chronic hepatitis C virus (HCV) infection affects millions of people worldwide and is associated with cancer. Direct\u2010acting antivirals (DAAs) have changed HCV treatment paradigms, but little is known about the management of HCV infection in patients with cancer. The substantial burden of HCV infection and the inconclusive evidence regarding its detection and management in patients with cancer prompted the authors to review the literature and formulate recommendations. Patients for whom HCV screening is recommended included all patients with hematologic malignancies, hematopoietic cell transplantation candidates, and patients with liver cancer. There is a lack of consensus\u2010based recommendations for the identification of HCV\u2010infected patients with other types of cancer, but physicians may at least consider screening patients who belong to groups at heightened risk of HCV infection, including those born during 1945 through 1965 and those at high risk for infection. Patients with evidence of HCV infection should be assessed by an expert to evaluate liver disease severity, comorbidities associated with HCV infection, and treatment opportunities. DAA therapy should be tailored on the basis of patient prognosis, type of cancer, cancer treatment plan, and hepatic and virologic parameters. HCV\u2010infected patients with cancer who have cirrhosis (or even advanced fibrosis) and those at risk for liver disease progression, especially patients with HCV\u2010associated comorbidities, should have ongoing follow\u2010up, regardless of whether there is a sustained virologic response, to ensure timely detection and treatment of hepatocellular carcinoma. HCV infection and its treatment should not be considered contraindications to cancer treatment and should not delay the initiation of an urgent cancer therapy. CA Cancer J Clin 2017. \u00a9 2017 American Cancer Society.\n                    <jats:bold>CA Cancer J Clin 2017;67:411\u2013431.<\/jats:bold>\n                    <jats:bold>\u00a9 2017 American Cancer Society.<\/jats:bold>\n                  <\/jats:p>","DOI":"10.3322\/caac.21403","type":"journal-article","created":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T12:06:37Z","timestamp":1499342797000},"page":"411-431","source":"Crossref","is-referenced-by-count":73,"title":["The oncologic burden of hepatitis C virus infection: A clinical perspective"],"prefix":"10.3322","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0814-604X","authenticated-orcid":false,"given":"Harrys A.","family":"Torres","sequence":"first","affiliation":[{"name":"Associate Professor, Department of Infectious Diseases, Infection Control and Employee Health The University of Texas MD Anderson Cancer Center Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terri Lynn","family":"Shigle","sequence":"additional","affiliation":[{"name":"Clinical Pharmacy Specialist, Division of Pharmacy, Section of Clinical Pharmacy Services The University of Texas MD Anderson Cancer Center Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nassim","family":"Hammoudi","sequence":"additional","affiliation":[{"name":"Gastrointestinal\/Hepatology Resident, Public Assistance \u2013 Paris Hospitals (AP\u2010HP) Hepatology Service, Cochin Port\u2010Royal Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James T.","family":"Link","sequence":"additional","affiliation":[{"name":"Hematology\/Oncology Fellow, Department of Gastrointestinal Medical Oncology The University of Texas MD Anderson Cancer Center Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Samaniego","sequence":"additional","affiliation":[{"name":"Associate Professor, Department of Lymphoma and Myeloma The University of Texas MD Anderson Cancer Center Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Kaseb","sequence":"additional","affiliation":[{"name":"Associate Professor, Department of Gastrointestinal Medical Oncology The University of Texas MD Anderson Cancer Center Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Mallet","sequence":"additional","affiliation":[{"name":"Professor of Hepatology, Public Assistance \u2013 Paris Hospitals (AP\u2010HP), Hepatology Service, Cochin Port\u2010Royal Hospital, Paris Descartes University (Paris V) National Institute of Health and Medical Research (INSERM), Unit 1223 Pasteur Institute Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,6]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)62401-6"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.04.021"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30559"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(16)30143-7"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.07.031"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2015.0007"},{"key":"e_1_2_17_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2015.07.033"},{"key":"e_1_2_17_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2014.12.005"},{"key":"e_1_2_17_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)00118-3"},{"key":"e_1_2_17_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2016.1196817"},{"key":"e_1_2_17_12_1","doi-asserted-by":"crossref","unstructured":"TorresHA EconomidesMP KyvernitakisA et al.Sofosbuvir\u2010based therapy in patients with chronic hepatitis C virus infection and malignancies\u2014a prospective observational study of 143 patients. 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