{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:27:02Z","timestamp":1787502422668,"version":"build-2736575974"},"reference-count":141,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T00:00:00Z","timestamp":1539734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA131044-01A1"],"award-info":[{"award-number":["R01 CA131044-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA227433"],"award-info":[{"award-number":["R01 CA227433"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 EB017722"],"award-info":[{"award-number":["R01 EB017722"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CA A Cancer J Clinicians"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Locoregional recurrence negatively impacts both long\u2010term survival and quality of life for several malignancies. For appropriate\u2010risk patients with an isolated, resectable, local recurrence, surgery represents the only potentially curative therapy. However, oncologic outcomes remain inferior for patients with locally recurrent disease even after macroscopically complete resection. Unfortunately, these operations are often extensive, with significant perioperative morbidity and mortality. This review highlights selected malignancies (mesothelioma, sarcoma, lung cancer, breast cancer, rectal cancer, and peritoneal surface malignancies) in which surgical resection is a key treatment modality and local recurrence plays a significant role in overall oncologic outcome with regard to survival and quality of life. For each type of cancer, the current, state\u2010of\u2010the\u2010art treatment strategies and their outcomes are assessed. The need for additional therapeutic options is presented given the limitations of the current standard therapies. New and emerging treatment modalities, including polymer films and nanoparticles, are highlighted as potential future solutions for both prevention and treatment of locally recurrent cancers. Finally, the authors identify additional clinical and research opportunities and propose future research strategies based on the various patterns of local recurrence among the different cancers.<\/jats:p>","DOI":"10.3322\/caac.21498","type":"journal-article","created":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T08:10:48Z","timestamp":1539763848000},"page":"488-505","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":248,"title":["Local Cancer Recurrence: The Realities, Challenges, and Opportunities for New Therapies"],"prefix":"10.3322","volume":"68","author":[{"given":"David A.","family":"Mahvi","sequence":"first","affiliation":[{"name":"Postdoctoral Research Fellow, Division of Surgical Oncology, Department of Surgery, Brigham and Women\u2019s Hospital Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Liu","sequence":"additional","affiliation":[{"name":"Instructor in Surgery, Division of Thoracic Surgery, Department of Surgery, Brigham and Women\u2019s Hospital Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W.","family":"Grinstaff","sequence":"additional","affiliation":[{"name":"Professor of Translational Research, Biomedical Engineering, Chemistry, Materials Science and Engineering, and Medicine, Department of Chemistry Boston University Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolonda L.","family":"Colson","sequence":"additional","affiliation":[{"name":"Michael A. Bell Family Distinguished Chair in Healthcare Innovation and Professor of Surgery, Division of Thoracic Surgery, Department of Surgery, Brigham and Women\u2019s Hospital Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandrajit P.","family":"Raut","sequence":"additional","affiliation":[{"name":"Associate Professor of Surgery, Division of Surgical Oncology, Department of Surgery, Brigham and Women\u2019s Hospital Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21442"},{"key":"e_1_2_11_3_1","volume-title":"Health, United States, 2016: With Chartbook on Long\u2010Term Trends in Health","author":"National Center for Health Statistics (US)","year":"2017"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2006.01018.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800830305"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-006-9256-9"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2013.1640"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.8879"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002212"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2009.11.011"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60484-0"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318190a664"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181fb7b82"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-014-0417-1"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2015.11.006"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-3287-9"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2827-z"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.256"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.14.779"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.51.7904"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-007-0260-8"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2011.01.017"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp501"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3332\/ecancer.2017.750"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/ejso.2001.1115"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1503\/cjs.025911"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001524"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.06.015"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020128"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022152"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70207-2"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.90"},{"key":"e_1_2_11_33_1","first-page":"CD005002","article-title":"Preoperative chemotherapy for women with operable breast cancer [serial online]","volume":"2","author":"Mieog JS","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3481-4"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.3273"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61629-2"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(98)00301-3"},{"key":"e_1_2_11_38_1","first-page":"CD007077","article-title":"Partial breast irradiation for early breast cancer [serial online]","volume":"6","author":"Lehman M","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(02)00219-8"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2011.07.020"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70589-8"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(00)00456-6"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.14.1143"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199504063321402"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.15.2817"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.11.015"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60488-8"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(96)00556-1"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002310"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.10.2071"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4741.2009.00716.x"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408440903044928"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001622-199104000-00014"},{"key":"e_1_2_11_54_1","first-page":"438","article-title":"Do we need a revised staging system for malignant pleural mesothelioma? Analysis of the IASLC database","volume":"1","author":"Rusch VW","year":"2012","journal-title":"Ann Cardiothorac Surg"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2017.03.82"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.10.054"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezv403"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.6813"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.02.046"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1547-4127(04)00109-4"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2014.10.041"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31827740f0"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2014.09.017"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2016.08.071"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.11.136"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01238-6"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2013.07.012"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0936-6555(05)80582-5"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2016.09.027"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30169-9"},{"issue":"15","key":"e_1_2_11_71_1","first-page":"LBA8508","article-title":"Second\u2010 or third\u2010line nivolumab (Nivo) versus nivo plus ipilimumab (Ipi) in malignant pleural mesothelioma (MPM) patients: results of the IFCT\u20101501 MAPS2 randomized phase II trial [abstract]","volume":"35","author":"Scherpereel A","year":"2018","journal-title":"J Clin Oncol"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(95)00537-U"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24625"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2017.04.024"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000664"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31196"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.74.9671"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezv462"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2007.094912"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2016.06.1815"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2010.06.001"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.5090\/kjtcs.2011.44.2.169"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62159-5"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.01.004"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2016.08.011"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2017.09.150"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.4115"},{"key":"e_1_2_11_88_1","volume-title":"Cancer Facts & Figures 2017","author":"American Cancer Society","year":"2017"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.0802"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001447"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010715)92:2<359::AID-CNCR1331>3.0.CO;2-Y"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000086542.11899.38"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0000000000000377"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24919"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr323"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70063-4"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70346-7"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20543"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2006.05.035"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-016-0751-2"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2011.02.004"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000978"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23808"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5336-7"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.67.6684"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2016-0025"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i41.6979"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v2.i2.68"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25356"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.05.040"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.7166"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3978-x"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2008.08.013"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13193-016-0504-6"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2011.11.031"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2015.00286"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.07.058"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18122702"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-015-3415-2"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.4103\/0975-7406.130965"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2016-0252"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2017.11.010"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp4006358"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.10.024"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2017.07.015"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-016-3217-1"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2011.03.036"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2016.05.021"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.06.031"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.11.038"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201000250"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep18720"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2013.07.014"},{"key":"e_1_2_11_134_1","first-page":"3341","article-title":"The role of Gliadel wafers in the treatment of newly diagnosed GBM: a meta\u2010analysis","volume":"9","author":"Xing WK","year":"2015","journal-title":"Drug Des Devel Ther"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0856-z"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1871-4"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.10.060"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2016.07.006"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2nr30731f"},{"key":"e_1_2_11_140_1","article-title":"Use of 5\u2010fluorouracil loaded micelles and cisplatin in thermosensitive chitosan hydrogel as an efficient therapy against colorectal peritoneal carcinomatosis [published online ahead of print October 20, 2016]","author":"Yun Q","journal-title":"Macromol Biosci"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2010.09.032"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.07.024"}],"container-title":["CA: A Cancer Journal for Clinicians"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.3322%2Fcaac.21498","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.3322\/caac.21498","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T08:39:23Z","timestamp":1762331963000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.3322\/caac.21498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,17]]},"references-count":141,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.3322\/caac.21498"],"URL":"https:\/\/doi.org\/10.3322\/caac.21498","archive":["Portico"],"relation":{},"ISSN":["0007-9235","1542-4863"],"issn-type":[{"value":"0007-9235","type":"print"},{"value":"1542-4863","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,17]]},"assertion":[{"value":"2018-07-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}