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Mindfulness\u2010based interventions are effective in reducing depressive symptoms and improving quality of life in patients with cancer. The objective of this review was to investigate whether mindfulness practices can improve survival and, if so, what mechanisms of action may contribute to these outcomes. Although no long\u2010term studies have investigated this hypothesis, the current literature supports an inflammatory basis for depression, implicating proinflammatory cytokines and hypothalamic\u2010pituitary\u2010adrenal axis dysfunction as contributing factors. Markers of inflammation, such as interleukin\u20106, tumor necrosis factor\u2010\u03b1, and cortisol, are all found at elevated concentrations in many depressed individuals. These exact mechanisms are associated with higher mortality in patients with cancer. Mindfulness has been studied for its effects on cytokine and cortisol levels, and there are promising data to support that the intervention can measurably decrease inflammation. Therefore, it is conceivable that mindfulness programs can affect survival in this population. There are limited data on the long\u2010term effects of mindfulness on depression and inflammatory markers in patients with cancer, and there are potential barriers to the implementation of mindfulness\u2010based interventions as part of a comprehensive treatment plan. Therefore, it is necessary to further explore these questions through longitudinal studies to establish a survival correlation.\n                    <jats:bold>CA Cancer J Clin. 2022;72:490\u2010502.<\/jats:bold>\n                  <\/jats:p>","DOI":"10.3322\/caac.21733","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T13:29:46Z","timestamp":1655386186000},"page":"490-502","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Examining the interrelationships between mindfulness\u2010based interventions, depression, inflammation, and cancer survival"],"prefix":"10.3322","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0882-0009","authenticated-orcid":false,"given":"Debra A.","family":"Marinovic","sequence":"first","affiliation":[{"name":"Department of Hematology, Oncology, and Cell Therapy Rush University Medical Center  Chicago Illinois USA"},{"name":"Arizona School of Health Sciences A. 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