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Although long\u2010term disease control can be achieved in a very large number of patients, the acquisition of tumor resistance leads to disease relapse, especially in patients with triple\u2010class refractory MM (defined as resistance to immunomodulatory agents, proteosome inhibitors, and monoclonal antibodies). There is an unmet need for effective treatment options in these patients. Chimeric antigen receptor (CAR) T\u2010cell therapy is a novel approach that has demonstrated promising efficacy in the treatment of relapsed, refractory MM (RRMM). These genetically modified cellular therapies have demonstrated deep and durable remissions in other B\u2010cell malignancies, and current efforts aim to achieve similar results in patients with RRMM. Early studies have demonstrated remarkable response rates with CAR T\u2010cell therapy in RRMM; however, durable responses with CAR T\u2010cell therapies in myeloma have yet to be realized. In this comprehensive review, the authors describe the development of CAR T\u2010cell therapies in myeloma, the outcomes of notable clinical trials, the toxicities and limitations of CAR T\u2010cell therapies, and the strategies to overcome therapeutic challenges of CAR T cells in the hope of achieving a cure for multiple myeloma.<\/jats:p>","DOI":"10.3322\/caac.21771","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T22:53:35Z","timestamp":1673391215000},"page":"275-285","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Chimeric antigen receptor T\u2010cell therapy in multiple myeloma: A comprehensive review of current data and implications for clinical practice"],"prefix":"10.3322","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7930-4354","authenticated-orcid":false,"given":"Rujul H.","family":"Parikh","sequence":"first","affiliation":[{"name":"Department of 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