{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:46:43Z","timestamp":1791492403373,"version":"4.3.4"},"reference-count":169,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T00:00:00Z","timestamp":1698192000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T00:00:00Z","timestamp":1698192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CA A Cancer J Clinicians"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The progression of cancer involves a critical step in which malignant cells escape from control by the immune system. Antineoplastic agents are particularly efficient when they succeed in restoring such control (immunosurveillance) or at least establish an equilibrium state that slows down disease progression. This is true not only for immunotherapies, such as immune checkpoint inhibitors (ICIs), but also for conventional chemotherapy, targeted anticancer agents, and radiation therapy. Thus, therapeutics that stress and kill cancer cells while provoking a tumor\u2010targeting immune response, referred to as\n                    <jats:italic>immunogenic cell death<\/jats:italic>\n                    , are particularly useful in combination with ICIs. Modern oncology regimens are increasingly using such combinations, which are referred to as\n                    <jats:italic>chemoimmunotherapy<\/jats:italic>\n                    , as well as combinations of multiple ICIs. However, the latter are generally associated with severe side effects compared with single\u2010agent ICIs. Of note, the success of these combinatorial strategies against locally advanced or metastatic cancers is now spurring successful attempts to move them past the postoperative (adjuvant) setting to the preoperative (neoadjuvant) setting, even for patients with operable cancers. Here, the authors critically discuss the importance of immunosurveillance in modern clinical cancer management.\n                  <\/jats:p>","DOI":"10.3322\/caac.21818","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T21:59:37Z","timestamp":1698271177000},"page":"187-202","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["Immunosurveillance in clinical cancer management"],"prefix":"10.3322","volume":"74","author":[{"given":"Guido","family":"Kroemer","sequence":"first","affiliation":[{"name":"Centre de Recherche des Cordeliers Equipe Labellis\u00e9e par la Ligue Contre le Cancer Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Universit\u00e9 Paris Cit\u00e9 Sorbonne Universit\u00e9 Institut Universitaire de France  Paris France"},{"name":"Metabolomics and Cell Biology Platforms Gustave Roussy Cancer Center  Villejuif France"},{"name":"Institut du Cancer Paris Carpem Department of Biology H\u00f4pital Europ\u00e9en Georges Pompidou Assistance Publique\u2010H\u00f4pital de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy A.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Taussig Cancer Center Cleveland Clinic  Cleveland Ohio USA"},{"name":"Center for Immunotherapy and Precision Immuno\u2010Oncology Cleveland Clinic  Cleveland Ohio USA"},{"name":"National Center for Regenerative Medicine  Cleveland Ohio USA"},{"name":"Case Comprehensive Cancer Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander M. 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