{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:12:58Z","timestamp":1793121178784,"version":"4.5.0"},"reference-count":106,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T00:00:00Z","timestamp":1711065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CA A Cancer J Clinicians"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Multicancer detection (MCD) tests use a single, easily obtainable biospecimen, such as blood, to screen for more than one cancer concurrently. MCD tests can potentially be used to improve early cancer detection, including cancers that currently lack effective screening methods. However, these tests have unknown and unquantified benefits and harms. MCD tests differ from conventional cancer screening tests in that the organ responsible for a positive test is unknown, and a broad diagnostic workup may be necessary to confirm the location and type of underlying cancer. Among two prospective studies involving greater than 16,000 individuals, MCD tests identified those who had some cancers without currently recommended screening tests, including pancreas, ovary, liver, uterus, small intestine, oropharyngeal, bone, thyroid, and hematologic malignancies, at early stages. Reported MCD test sensitivities range from 27% to 95% but differ by organ and are lower for early stage cancers, for which treatment toxicity would be lowest and the potential for cure might be highest. False reassurance from a negative MCD result may reduce screening adherence, risking a loss in proven public health benefits from standard\u2010of\u2010care screening. Prospective clinical trials are needed to address uncertainties about MCD accuracy to detect different cancers in asymptomatic individuals, whether these tests can detect cancer sufficiently early for effective treatment and mortality reduction, the degree to which these tests may contribute to cancer overdiagnosis and overtreatment, whether MCD tests work equally well across all populations, and the appropriate diagnostic evaluation and follow\u2010up for patients with a positive test.<\/jats:p>","DOI":"10.3322\/caac.21833","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T11:45:17Z","timestamp":1711107917000},"page":"368-382","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Cancer screening with multicancer detection tests: A translational science review"],"prefix":"10.3322","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8790-9959","authenticated-orcid":false,"given":"Wendy S.","family":"Rubinstein","sequence":"first","affiliation":[{"name":"Division of Cancer Prevention US National Cancer Institute  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6441-776X","authenticated-orcid":false,"given":"Christos","family":"Patriotis","sequence":"additional","affiliation":[{"name":"Division of Cancer Prevention US National Cancer Institute  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7265-8053","authenticated-orcid":false,"given":"Anthony","family":"Dickherber","sequence":"additional","affiliation":[{"name":"Center for Strategic Scientific Initiatives US National Cancer Institute  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0165-1940","authenticated-orcid":false,"given":"Paul K. J.","family":"Han","sequence":"additional","affiliation":[{"name":"Division of Cancer Control and Population Sciences US National Cancer Institute  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2002-0095","authenticated-orcid":false,"given":"Hormuzd A.","family":"Katki","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics US National Cancer Institute  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2581-9747","authenticated-orcid":false,"given":"Elyse","family":"LeeVan","sequence":"additional","affiliation":[{"name":"Division of Cancer Prevention US National Cancer Institute  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0350-3282","authenticated-orcid":false,"given":"Paul F.","family":"Pinsky","sequence":"additional","affiliation":[{"name":"Division of Cancer Prevention US National Cancer Institute  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2126-5847","authenticated-orcid":false,"given":"Philip C.","family":"Prorok","sequence":"additional","affiliation":[{"name":"Division of Cancer Prevention US National Cancer Institute  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3654-9076","authenticated-orcid":false,"given":"Amanda L.","family":"Skarlupka","sequence":"additional","affiliation":[{"name":"Division of Cancer Prevention US National Cancer Institute  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6472-2745","authenticated-orcid":false,"given":"Sarah M.","family":"Temkin","sequence":"additional","affiliation":[{"name":"National Institutes of Health Office of Research on Women's Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6408-5985","authenticated-orcid":false,"given":"Philip E.","family":"Castle","sequence":"additional","affiliation":[{"name":"Division of Cancer Prevention US National Cancer Institute  Rockville Maryland USA"},{"name":"Division of Cancer Epidemiology and Genetics US National Cancer Institute  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0472-4079","authenticated-orcid":false,"given":"Lori M.","family":"Minasian","sequence":"additional","affiliation":[{"name":"Division of Cancer Prevention US National Cancer Institute  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"key":"e_1_2_5_3_1","volume-title":"Cancer","author":"World Health Organization (WHO)","year":"2024"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.CD\u201023\u20100208"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.CD\u201023\u20100344"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055\u20109965.EPI\u201020\u20100240"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2764"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/haschl\/qxad005"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1370\/afm.2946"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.5888\/pcd19.220063"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.43163"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1370\/afm.942"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.2440"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41698\u2010018\u20100066\u2010x"},{"key":"e_1_2_5_15_1","volume-title":"Evolution of Translational Omics: Lessons Learned and the Path Forward","author":"Committee on the Review of Omics\u2010Based Tests for Predicting Patient Outcomes in Clinical Trials, Board on Health Care Services; Board on Health Sciences Policy; Institute of Medicine","year":"2012"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.13427"},{"key":"e_1_2_5_17_1","volume-title":"Evaluating multicancer early detection (MCED) technologies for clinical use","author":"Multicancer Early Detection Consortium (MCED)","year":"2022"},{"key":"e_1_2_5_18_1","volume-title":"Blood Tests That Detect Cancers Create Risks for Those Who Use Them","author":"Kolata G","year":"2022"},{"key":"e_1_2_5_19_1","volume-title":"New cancer screen, same issues: physicians confront Galleri test","author":"Coffey D","year":"2023"},{"key":"e_1_2_5_20_1","volume-title":"The Role of Lab\u2010Developed Tests in the In Vitro Diagnostics Market","author":"The Pew Charitable Trusts","year":"2021"},{"key":"e_1_2_5_21_1","volume-title":"Laboratory Developed Tests","author":"US Food and Drug Administration (FDA)","year":"2024"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/labmed\/lmaa086"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2022.10.022"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010019\u20106003\u20108"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416\u2010020\u201001047\u20105"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010019\u20101272\u20106"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar3247"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb9601"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201032995\u20106"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2020.1790950"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148\u2010022\u201001246\u20102"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551\u2010021\u201000746\u20105"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.02.011"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz394.074"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201017316\u2010z"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2017.106"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010018\u20100703\u20100"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1313995110"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14174221"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djy126"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2015.09.004"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158285"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2018.04.015"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2115328119"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043578"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000450"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12051147"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43856\u2010022\u201000088\u20106"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14581"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40364\u2010022\u201000404\u20101"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201018\u20100887"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015\u2010021\u201010167\u20101"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22278"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.7120"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201021\u20100417"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2018.03.020"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(23)01700\u20102"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.05.806"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2021.101016"},{"key":"e_1_2_5_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432\u2010021\u201003517\u20106"},{"key":"e_1_2_5_61_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.7779"},{"key":"e_1_2_5_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djz182"},{"key":"e_1_2_5_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13040913"},{"key":"e_1_2_5_64_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.Ccr\u201021\u20100110"},{"key":"e_1_2_5_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010020\u20100933\u20101"},{"key":"e_1_2_5_66_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.581157"},{"key":"e_1_2_5_67_1","doi-asserted-by":"publisher","DOI":"10.1109\/EMBC.2018.8513553"},{"key":"e_1_2_5_68_1","doi-asserted-by":"publisher","unstructured":"Anna BergamaschiYN KuC\u2010J EllisonC et\u00a0al.Pilot study demonstrating changes in DNA hydroxymethylation enable detection of multiple cancers in plasma cell\u2010free DNA[preprint].bioRxiv.2020:1\u201024. doi:10.1101\/2020.01.22.20018382","DOI":"10.1101\/2020.01.22.20018382"},{"key":"e_1_2_5_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14143341"},{"key":"e_1_2_5_70_1","volume-title":"Tests for Cancer Screening","author":"Guardant","year":"2024"},{"key":"e_1_2_5_71_1","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2017.1412907"},{"key":"e_1_2_5_72_1","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2019.1695333"},{"key":"e_1_2_5_73_1","unstructured":"Rivela Diagnostics.Rivela Diagnostics Publications. Accessed February 1 2024.https:\/\/www.riveladx.com\/news\/index"},{"key":"e_1_2_5_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010020\u20100932\u20102"},{"key":"e_1_2_5_75_1","unstructured":"Freenome.Our Multiomics Platform. Accessed February 01 2024.https:\/\/www.freenome.com\/early\u2010cancer\u2010detection\/multiomics\u2010platform"},{"key":"e_1_2_5_76_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/93.14.1054"},{"key":"e_1_2_5_77_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.01572"},{"key":"e_1_2_5_78_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14194818"},{"key":"e_1_2_5_79_1","volume-title":"Screening Research Network (CSRN)","author":"National Institute of Cancer (NCI)","year":"2024"},{"key":"e_1_2_5_80_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djac218"},{"key":"e_1_2_5_81_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.766"},{"key":"e_1_2_5_82_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djab168"},{"key":"e_1_2_5_83_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.19872"},{"key":"e_1_2_5_84_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016161174"},{"key":"e_1_2_5_85_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14\u20102086"},{"key":"e_1_2_5_86_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1102873"},{"key":"e_1_2_5_87_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1911793"},{"key":"e_1_2_5_88_1","doi-asserted-by":"publisher","DOI":"10.7326\/L16\u20100404"},{"key":"e_1_2_5_89_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1114635"},{"key":"e_1_2_5_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(10)60551\u2010X"},{"key":"e_1_2_5_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(21)00731\u20105"},{"key":"e_1_2_5_92_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1591"},{"key":"e_1_2_5_93_1","volume-title":"Screening programmes: a short guide. Increase effectiveness, maximize benefits and minimize harm","author":"World Health Organization (WHO)","year":"2020"},{"key":"e_1_2_5_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.12354"},{"key":"e_1_2_5_95_1","volume-title":"Digital Tomosynthesis Mammography and Digital Mammography in Screening Patients for Breast Cancer [ClinicalTrials.gov identifier NCT03233191]","author":"ECOG\u2010ACRIN Cancer Research Group","year":"2023"},{"key":"e_1_2_5_96_1","volume-title":"SEER*Explorer: An interactive website for SEER cancer statistics [Internet]","author":"National Cancer Institute Surveillance Research Program","year":"2024"},{"key":"e_1_2_5_97_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055\u20109965.EPI\u201022\u20100024"},{"key":"e_1_2_5_98_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/hvad134"},{"key":"e_1_2_5_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.07.1034"},{"key":"e_1_2_5_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006\u2010341X.2004.00023.x"},{"key":"e_1_2_5_101_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i5745"},{"key":"e_1_2_5_102_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1409841"},{"key":"e_1_2_5_103_1","doi-asserted-by":"publisher","DOI":"10.5888\/pcd15.170465"},{"key":"e_1_2_5_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24633"},{"key":"e_1_2_5_105_1","doi-asserted-by":"publisher","DOI":"10.7326\/M23\u20100067"},{"key":"e_1_2_5_106_1","volume-title":"A Friends of Cancer Research White Paper","author":"Friends of Cancer Research","year":"2022"},{"key":"e_1_2_5_107_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx766"}],"container-title":["CA: A Cancer Journal for Clinicians"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.3322\/caac.21833","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T09:22:08Z","timestamp":1762334528000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.3322\/caac.21833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,22]]},"references-count":106,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.3322\/caac.21833"],"URL":"https:\/\/doi.org\/10.3322\/caac.21833","archive":["Portico"],"relation":{},"ISSN":["0007-9235","1542-4863"],"issn-type":[{"value":"0007-9235","type":"print"},{"value":"1542-4863","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,22]]},"assertion":[{"value":"2023-12-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}