{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:36:15Z","timestamp":1791401775100,"version":"4.3.3"},"reference-count":211,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CA A Cancer J Clinicians"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The first 5 decades of research in acute myeloid leukemia (AML) were dominated by the cytarabine plus anthracyclines backbone, with advances in strategies including allogeneic hematopoietic stem cell transplantation, high\u2010dose cytarabine, supportive care measures, and targeted therapies for the subset of patients with acute promyelocytic leukemia. Since 2017, a turning point in AML research, 12 agents have received regulatory approval for AML in the United States: venetoclax (BCL2 inhibitor); gemtuzumab ozogamicin (CD33 antibody\u2013drug conjugate); midostaurin, gilteritinib, and quizartinib (fms\u2010like tyrosine kinase 3 inhibitors); ivosidenib, olutasidenib, and enasidenib (isocitrate dehydrogenase 1 and 2 inhibitors); oral azacitidine (a partially absorbable formulation); CPX351 (liposomal encapsulation of cytarabine:daunorubicin at a molar ratio of 5:1); glasdegib (hedgehog inhibitor); and recently revumenib (menin inhibitor; approved November 2024). Oral decitabine\u2010cedazuridine, which is approved as a bioequivalent alternative to parenteral hypomethylating agents in myelodysplastic syndrome, can be used for the same purpose in AML. Menin inhibitors, CD123 antibody\u2013drug conjugates, and other antibodies targeting CD123, CD33, and other surface markers are showing promising results. Herein, the authors review the frontline and later line therapies in AML and discuss important research directions.<\/jats:p>","DOI":"10.3322\/caac.21873","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T10:10:19Z","timestamp":1733825419000},"page":"46-67","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":118,"title":["Acute myeloid leukemia management and research in 2025"],"prefix":"10.3322","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1908-3307","authenticated-orcid":false,"given":"Hagop M.","family":"Kantarjian","sequence":"first","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9003-0390","authenticated-orcid":false,"given":"Courtney D.","family":"DiNardo","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapan M.","family":"Kadia","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7103-373X","authenticated-orcid":false,"given":"Naval G.","family":"Daver","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica K.","family":"Altman","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Department of Medicine Robert H. Lurie Comprehensive Cancer Center Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eytan M.","family":"Stein","sequence":"additional","affiliation":[{"name":"Leukemia Service Department of Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Jabbour","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A.","family":"Schiffer","sequence":"additional","affiliation":[{"name":"Karmanos Cancer Center Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Lang","sequence":"additional","affiliation":[{"name":"START Center for Cancer Care  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7621-377X","authenticated-orcid":false,"given":"Farhad","family":"Ravandi","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102016\u201011\u2010750182"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v89.9.3354"},{"issue":"6","key":"e_1_2_10_4_1","first-page":"1490","article-title":"Approval summary: gemtuzumab ozogamicin in relapsed acute myeloid leukemia","volume":"7","author":"Bross PF","year":"2001","journal-title":"Clin Cancer Res"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07485"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1301689"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408\u2010021\u201000425\u20103"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24246"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33477"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2021.05.016"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103026(21)00270\u20102"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.11.004"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0901409"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904544"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(14)70281\u20105"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2004444"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2017.77.6112"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2352\u20103026(23)00338\u20101"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010021\u201001309\u2010y"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010023\u201005812\u20103"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102009\u201011\u2010254441"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1516192"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.19.00416"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019003988"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022008316"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2007.14.0418"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26731"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1158\/2643\u20103230.Bcd\u201020\u20100143"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.588876"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32566"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27236"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2013.52.3480"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa074306"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102016\u201009\u2010736686"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.35662"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23795"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26700"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.23.00943"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/hem3.104"},{"key":"e_1_2_10_40_1","article-title":"First\u2010in\u2010human phase 1\/2 study of the menin\u2010MLL inhibitor DSP\u20105336 in patients with relapsed or refractory acute leukemia: updated results from dose escalation [abstract]","author":"Daver N","year":"2024","journal-title":"Hemasphere"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/hem3.104"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/hem3.104"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2352\u20103026(23)00089\u20103"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024024310"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020005998"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019003471"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408\u2010024\u201001103\u2010w"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023011757"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024024944"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30203"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.Cd\u201022\u20100332"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26941"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26557"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34609"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1614359"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(23)00464\u20106"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27054"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102023\u2010182466"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26451"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408\u2010024\u201001069\u20109"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022016867"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010020\u20100920\u2010z"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102012\u201006\u2010431122"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102014\u201005\u2010578070"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25670"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27070"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25610"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.HS9.0000967432.73477.1d"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102023\u2010180482"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0247093"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(21)00494\u20100"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27246"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2117344"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102023\u2010182944"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1158\/2643\u20103230.Bcd\u201022\u20100205"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408\u2010022\u201000670\u20100"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.23.01911"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/hem3.104"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2006.06.9500"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1716863"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102014\u201005\u2010577593"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.9452"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.9643"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30361"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2020.4600"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.19.03011"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2011.35.0371"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022009391"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010022\u201001692\u20100"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26698"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1158\/2643\u20103230.Bcd\u201023\u20100144"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102012\u201006\u2010435669"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102012\u201011\u2010468348"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1507471"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023023096"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.1363"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.23.02474"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.093765"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021004367"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409\u2010021\u201001407\u20106"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102010\u201008\u2010302950"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2008.18.6130"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(15)00193\u2010x"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2016.67.1982"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019001278"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102018\u201005\u2010851824"},{"issue":"1","key":"e_1_2_10_107_1","first-page":"5","article-title":"First results of the APOLLO trial: a randomized phase III study to compare ATO combined with ATRA versus standard AIDA regimen for patients with newly diagnosed, high\u2010risk acute promyelocytic leukemia [abstract]","volume":"8","author":"Platzbecker U","year":"2024","journal-title":"Hemasphere"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404272"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32196"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2023.2290467"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408\u2010024\u201001143\u20102"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2004.07.012"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2010.31.4310"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408\u2010023\u201000928\u20101"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V122.21.357.357"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/hem3.104"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33458"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199410063311402"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2012.47.4874"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v88.8.2841.bloodjournal8882841"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v87.5.1710.1710"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21543"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2013.51.8571"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018026625"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010023\u201002073\u2010x"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1010222"},{"issue":"11","key":"e_1_2_10_127_1","first-page":"3005","article-title":"Saturation of 1\u2010beta\u2010D\u2010arabinofuranosylcytosine 5'\u2010triphosphate accumulation in leukemia cells during high\u2010dose 1\u2010beta\u2010D\u2010arabinofuranosylcytosine therapy","volume":"47","author":"Plunkett W","year":"1987","journal-title":"Cancer Res"},{"issue":"2","key":"e_1_2_10_128_1","first-page":"159","article-title":"Saturation of ara\u2010CTP accumulation during high\u2010dose ara\u2010C therapy: pharmacologic rationale for intermediate\u2010dose ara\u2010C","volume":"14","author":"Plunkett W","year":"1987","journal-title":"Semin Oncol"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v93.8.2478"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V122.21.2692.2692"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403336"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2011.37.1286"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102015\u201001\u2010623447"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102022\u2010157126"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(12)60485\u20101"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V118.21.79.79"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2017.1349907"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13010034"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25057"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2020.106318"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14107"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1002\/hem3.104"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1002\/hem3.104"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1002\/hem3.104"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102023\u2010185956"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1002\/hem3.104"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.20.03736"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2352\u20103026(21)00192\u20107"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2352\u20103026(22)00076\u2010x"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2024.42.16_suppl.6519"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.20.00572"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2352\u20103026(22)00106\u20105"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102015\u201007\u2010627323"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061094"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2352\u20103026(24)00034\u20106"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.22.02721"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(20)30455\u20101"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.19.03345"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102015\u201008\u2010662130"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2018.03.006"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020007233"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408\u2010021\u201000557\u20106"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21723"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102010\u201003\u2010276485"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002512\u2010200522110\u201000004"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22496"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2011.38.9429"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102015\u201001\u2010621664"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26667"},{"key":"e_1_2_10_170_1","doi-asserted-by":"publisher","DOI":"10.1097\/ppo.0000000000000568"},{"key":"e_1_2_10_171_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.Cd\u201013\u20100609"},{"key":"e_1_2_10_172_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.Cd\u201016\u20100313"},{"key":"e_1_2_10_173_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.18.01600"},{"key":"e_1_2_10_174_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102018\u201008\u2010868752"},{"key":"e_1_2_10_175_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2012971"},{"key":"e_1_2_10_176_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102022\u2010158518"},{"key":"e_1_2_10_177_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020004856"},{"key":"e_1_2_10_178_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26061"},{"key":"e_1_2_10_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2015.11.016"},{"key":"e_1_2_10_180_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33403"},{"key":"e_1_2_10_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2352\u20103026(18)30132\u20107"},{"key":"e_1_2_10_182_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29367"},{"key":"e_1_2_10_183_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26206"},{"key":"e_1_2_10_184_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13164189"},{"key":"e_1_2_10_185_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408\u2010024\u201000982\u20103"},{"key":"e_1_2_10_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2352\u20103026(20)30210\u20106"},{"key":"e_1_2_10_187_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010023\u201005102\u2010y"},{"key":"e_1_2_10_188_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27180"},{"key":"e_1_2_10_189_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2024.42.16_suppl.6507"},{"key":"e_1_2_10_190_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.21.02823"},{"key":"e_1_2_10_191_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102023\u2010182250"},{"key":"e_1_2_10_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2352\u20103026(22)00167\u20103"},{"key":"e_1_2_10_193_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102023\u2010182337"},{"key":"e_1_2_10_194_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010018\u20100312\u20109"},{"key":"e_1_2_10_195_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010023\u201002001\u2010z"},{"key":"e_1_2_10_196_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010023\u201002049\u2010x"},{"key":"e_1_2_10_197_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102018\u201010\u2010879866"},{"key":"e_1_2_10_198_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24767"},{"key":"e_1_2_10_199_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31296"},{"key":"e_1_2_10_200_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.813"},{"key":"e_1_2_10_201_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102141.2002.03724.x"},{"key":"e_1_2_10_202_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26997"},{"key":"e_1_2_10_203_1","doi-asserted-by":"publisher","DOI":"10.1002\/hem3.104"},{"key":"e_1_2_10_204_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2024.01.015"},{"key":"e_1_2_10_205_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102010\u201007\u2010296392"},{"key":"e_1_2_10_206_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31370"},{"key":"e_1_2_10_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(23)00674\u20105"},{"key":"e_1_2_10_208_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102018\u201099\u2010111915"},{"key":"e_1_2_10_209_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.Hs9.0000967904.29417.23"},{"key":"e_1_2_10_210_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25284"},{"key":"e_1_2_10_211_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30545"},{"key":"e_1_2_10_212_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29512"}],"container-title":["CA: A Cancer Journal for Clinicians"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.3322\/caac.21873","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T17:25:23Z","timestamp":1762363523000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.3322\/caac.21873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,10]]},"references-count":211,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.3322\/caac.21873"],"URL":"https:\/\/doi.org\/10.3322\/caac.21873","archive":["Portico"],"relation":{},"ISSN":["0007-9235","1542-4863"],"issn-type":[{"value":"0007-9235","type":"print"},{"value":"1542-4863","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,10]]},"assertion":[{"value":"2024-10-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}