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Advances in such techniques as intensity\u2010modulated and stereotactic body radiation therapy have improved precision, making reRT a viable option for complex scenarios previously deemed high\u2010risk. Nevertheless, reRT remains associated with substantial risks\u2014including life\u2010threatening side effects, functional impairments, and psychosocial effects\u2014which must be carefully balanced against the patient's overall health and the likelihood of achieving cancer control or palliation. Patient selection is essential to optimize outcomes while mitigating risks. Decisions should account for tumor characteristics at the time of primary diagnosis and recurrence, elapsed time since prior treatment, the possibility of delivering meaningful doses to the tumor, and the cumulative irradiation tolerance of normal tissues. Advanced imaging modalities, such as functional magnetic resonance imaging and fluorine\u201018\u2013labeled fluorodeoxyglucose\u2013positron emission tomography, are important for distinguishing recurrences from treatment\u2010induced changes, refining treatment targets, and minimizing exposure to healthy tissue. Combined treatment with systemic regimens\u2014targeted therapies and immunotherapy in particular\u2014offers promising opportunities but requires coordination to manage side effects. Standardized guidelines, such as those from the European Society of Therapeutic Radiology and Oncology\u2010European Society for Research and Treatment of Cancer, are essential for improving the consistency of reporting, guiding clinical decision making, and fostering patient\u2010centered care. Multidisciplinary collaboration and ongoing research, particularly through clinical trials, are central to fully exploiting reRT strategies. In addition, the development of innovative techniques, such as proton therapy, would likely enable safer treatments. These efforts aim to improve the therapeutic balance of reRT, enhancing outcomes and quality of life.<\/jats:p>","DOI":"10.3322\/caac.70016","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T05:42:05Z","timestamp":1748497325000},"page":"630-666","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Reirradiation: Standards, challenges, and patient\u2010focused strategies across tumor types"],"prefix":"10.3322","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5512-4161","authenticated-orcid":false,"given":"Arnaud","family":"Beddok","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Institut Godinot  Reims France"},{"name":"Research Center in Information and Communication Sciences and Technologies University of Champagne\u2010Ardenne  Reims France"},{"name":"Department of Radiology and Biomedical Imaging Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2531-3551","authenticated-orcid":false,"given":"Jonas","family":"Willmann","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University Hospital Zurich University of Zurich  Zurich Switzerland"},{"name":"Department of Medical Physics Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5147-3276","authenticated-orcid":false,"given":"Anna","family":"Embring","sequence":"additional","affiliation":[{"name":"Department of Oncology Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Oncology\u2010Pathology Karolinska Institute  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2792-9218","authenticated-orcid":false,"given":"Ane L.","family":"Appelt","sequence":"additional","affiliation":[{"name":"Leeds Institute of Medical Research University of Leeds  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5261-6446","authenticated-orcid":false,"given":"Panagiotis","family":"Balermpas","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University Hospital Zurich University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1338-0781","authenticated-orcid":false,"given":"Kevin","family":"Chua","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology National Cancer Centre Singapore  Singapore Singapore"},{"name":"Duke\u2010National University of Singapore Medical School National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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