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Chronic radiation\u2010induced conditions\u2014including skin fibrosis, bone necrosis, radiation cystitis, and proctitis\u2014pose substantial challenges for both patients and caregivers, particularly in the context of improving long\u2010term cancer survival. Hyperbaric oxygen therapy, characterized by the promotion of angiogenesis, fibroblast activation, and tissue remodeling in hypoxic environments, has emerged as a potential adjunctive treatment for mitigating these late effects. Herein, the authors critically evaluate randomized trials, cohort studies, and real\u2010world data while highlighting gaps in knowledge, including patient selection, optimal treatment protocols, and long\u2010term outcomes. In addition, they discuss practical considerations and health system implications of the integration of hyperbaric oxygen therapy into survivorship care. The objective of this review is to provide clinicians with an evidence\u2010informed framework to guide decision making in the multidisciplinary management of radiation\u2010related late effects.<\/jats:p>","DOI":"10.3322\/caac.70058","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T16:50:59Z","timestamp":1765558259000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hyperbaric oxygen therapy for chronic radiotherapy\u2010related adverse effects: A clinically focused review"],"prefix":"10.3322","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4527-4024","authenticated-orcid":false,"given":"Cas Stefaan","family":"Dejonckheere","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6260-5249","authenticated-orcid":false,"given":"Lukas","family":"K\u00e4smann","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University Hospital M\u00fcnchen  Munich Germany"},{"name":"Department of Radiation Oncology Klinikum Landshut  Landshut Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3901-4122","authenticated-orcid":false,"given":"Leonard Christopher","family":"Schmeel","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University Hospital Bonn  Bonn Germany"},{"name":"Department of Radiation Oncology Cologne Municipal Hospitals University Hospital of the University of Witten\u2010Herdecke  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Walter","sequence":"additional","affiliation":[{"name":"Federal Association of Laryngeal and Head and Neck Tumors e.V.  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Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7538-9057","authenticated-orcid":false,"given":"Eleni","family":"Gkika","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian Philipp","family":"Layer","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University Hospital Bonn  Bonn Germany"},{"name":"Institute of Experimental Oncology University Hospital Bonn  Bonn 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