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Every 3 years, the American Cancer Society reports on CRC occurrence based on incidence from population\u2010based cancer registries and mortality from the National Center for Health Statistics. Overall, CRC incidence declined by 0.9% annually during 2013\u20132022 driven by decreases of 2.5% annually in adults aged 65 years and older. In sharp contrast, incidence rates increased by 3% annually in adults aged 20\u201349 years and by 0.4% annually in adults aged 50\u201364 years dominated by tumors in the distal colon and rectum. Consequently, overall rectal cancer incidence increased by 1% annually from 2018 to 2022 after decades of decline and now accounts for 32% of all CRC, up from 27% in the mid\u20102000s. Increasing CRC incidence in adults aged 50\u201364 years was confined to regional and distant\u2010stage diagnosis (1.1%\u20131.3% annually during 2013\u20132022), likely contributing to an upturn in mortality in this age group of 1% annually since 2019 that was steepest (2.3% annually) in White individuals. Mortality has increased in adults younger than 50 years by 1% annually since 2004, whereas rates have decreased in adults 65 years and older by 2.3% annually since 2012. Despite steady progress for older adults, both CRC incidence and mortality are increasing in adults younger than 65 years who are in the prime of life, underscoring an urgent need for etiologic research to discover the cause of the rising trend. Meanwhile, morbidity and mortality could be mitigated with earlier diagnosis, through screening and educating clinicians and the general public about CRC symptoms, and greater attention to the unique needs of younger patients, including discussion about the preservation of fertility and sexual health.<\/jats:p>","DOI":"10.3322\/caac.70067","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:10:16Z","timestamp":1772957416000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Colorectal cancer statistics, 2026"],"prefix":"10.3322","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5247-8522","authenticated-orcid":false,"given":"Rebecca L.","family":"Siegel","sequence":"first","affiliation":[{"name":"Surveillance, Prevention, and Health Services Research American Cancer Society  Atlanta Georgia 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