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Accumulating evidence shows that prostate\u2010specific antigen (PSA)\u2010based screening significantly reduces prostate cancer mortality and advanced\u2010stage diagnosis, and approaches to reduce harms associated with screening are increasingly being used. The ACS conducted a systematic review and commissioned a modeling study to evaluate PSA\u2010based screening strategies, and concluded that the benefits of screening outweigh the harms. Before initiating screening, clinicians should ensure that patients are informed about the benefits, limitations, and harms of screening; the potential follow\u2010up evaluations of elevated PSA levels; and the expectation that low\u2010risk cancers will initially be managed with active surveillance. The ACS recommends biennial screening from ages 50\u201069 years for average\u2010risk men (i.e., non\u2010Black men without a family history of prostate cancer). Annual screening from ages 45\u201069 years is recommended for Black men. Annual screening from ages 45\u201369 years is recommended for non\u2010Black men with a strong family history (i.e., multiple first\u2010degree relatives diagnosed with prostate cancer at any age or one diagnosed before age 65 years). Biennial screening from ages 45\u201069 years is recommended for non\u2010Black men with a single first\u2010degree relative diagnosed at age 65 years or older. For men ages 70\u201374 years, the balance of benefits and harms is uncertain, and individualized decision making is recommended. The ACS recommends further evaluating men ages 45\u201369 years with PSA levels \u22653.0 ng\/mL and men ages 70\u201374 years with PSA levels \u22656.5 ng\/mL. Most men who have elevated PSA levels confirmed on repeat testing should be offered magnetic resonance imaging and\/or a validated biomarker test to guide biopsy decisions. Screening is not recommended for men with a life expectancy &lt;10 years and should be discontinued at age 75 years.<\/jats:p>","DOI":"10.3322\/caac.70112","type":"journal-article","created":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T12:00:10Z","timestamp":1794484810000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["American Cancer Society guideline for the early detection of prostate cancer, 2026"],"prefix":"10.3322","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4714-7726","authenticated-orcid":false,"given":"Richard M.","family":"Hoffman","sequence":"first","affiliation":[{"name":"University of Iowa Carver College of Medicine  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5510-7224","authenticated-orcid":false,"given":"Andrew M.\u00a0D.","family":"Wolf","sequence":"additional","affiliation":[{"name":"University of Virginia School of Medicine  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9164-6370","authenticated-orcid":false,"given":"Ruth D.","family":"Etzioni","sequence":"additional","affiliation":[{"name":"Biostatistics Program Fred Hutch Cancer Center  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0806-7894","authenticated-orcid":false,"given":"Kevin C.","family":"Oeffinger","sequence":"additional","affiliation":[{"name":"Duke Cancer Institute Center for Onco\u2010Primary Care Duke University  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2977-8687","authenticated-orcid":false,"given":"Sana","family":"Raoof","sequence":"additional","affiliation":[{"name":"Radiation Oncology Brown University Health Brown School of Public Health  Providence Rhode Island USA"},{"name":"Biostatistics Brown School of Public Health  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9642-6238","authenticated-orcid":false,"given":"Louise C.","family":"Walter","sequence":"additional","affiliation":[{"name":"Division of Geriatrics, Department of Medicine University of California\u2010San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2641-7755","authenticated-orcid":false,"given":"Charnita","family":"Zeigler\u2010Johnson","sequence":"additional","affiliation":[{"name":"Cancer Prevention and Control Fox Chase Cancer Center  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3292-5035","authenticated-orcid":false,"given":"Timothy R.","family":"Church","sequence":"additional","affiliation":[{"name":"University of Minnesota School of Public Health  Minneapolis Minnesota USA"},{"name":"Masonic Cancer Center  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher K.","family":"Jones","sequence":"additional","affiliation":[{"name":"Columbia Memorial Health  Hudson New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7525-1080","authenticated-orcid":false,"given":"Artie L.","family":"Shelton","sequence":"additional","affiliation":[{"name":"Prostate Health Education Network, Inc.  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