{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T10:30:11Z","timestamp":1794047411186,"version":"4.8.0"},"reference-count":91,"publisher":"Ferrata Storti Foundation (Haematologica)","issue":"6","license":[{"start":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T00:00:00Z","timestamp":1652918400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/legalcode"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["haematol"],"abstract":"<jats:p>The new techniques of genetic analysis have made it possible to identify many new forms of inherited thrombocytopenias (IT) and study large series of patients. In recent years, this has changed the view of IT, highlighting the fact that, in contrast to previous belief, most patients have a modest bleeding diathesis. On the other hand, it has become evident that some of the mutations responsible for platelet deficiency predispose the patient to serious, potentially lifethreatening diseases. Today's vision of IT is, therefore, very different from that of the past and the therapeutic approach must take these changes into account while also making use of the new therapies that have become available in the meantime. This review, the first devoted entirely to IT therapy, discusses how to prevent bleeding in those patients who are exposed to this risk, how to treat it if it occurs, and how to manage the serious illnesses to which patients with IT may be predisposed.<\/jats:p>","DOI":"10.3324\/haematol.2022.280856","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T15:09:02Z","timestamp":1654096142000},"page":"1278-1292","source":"Crossref","is-referenced-by-count":25,"title":["Treatment of inherited thrombocytopenias"],"prefix":"10.3324","volume":"107","author":[{"given":"Carlo L.","family":"Balduini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1856","published-online":{"date-parts":[[2022,5,19]]},"reference":[{"key":"36363","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.233197"},{"key":"36364","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094521"},{"key":"36365","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2020.100784"},{"key":"36366","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06343.x"},{"key":"36367","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2013.02.004"},{"key":"36368","doi-asserted-by":"publisher","DOI":"10.1016\/j.tracli.2018.07.003"},{"key":"36369","unstructured":"Garraud O, Cognasse F, Tissot JD. Improving platelet transfusion safety: biomedical and technical considerations. Blood Transfus. 2016; 14(2):109-122."},{"key":"36370","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199712253372601"},{"key":"36371","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2034764"},{"key":"36372","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2020000137"},{"key":"36373","doi-asserted-by":"publisher","DOI":"10.1016\/S0037-1963(01)90122-2"},{"key":"36374","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12558"},{"key":"36375","unstructured":"Peaceman AM, Katz AR, Laville M.. Bernard-Soulier syndrome complicating pregnancy: a case report. Obstet Gynecol. 1989; 73(3 Pt 2):457-459."},{"key":"36376","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.250720"},{"key":"36377","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.160754"},{"key":"36378","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb08385.x"},{"key":"36379","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01902.x"},{"key":"36380","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2006.10.018"},{"key":"36381","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.121384"},{"key":"36382","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1328881"},{"key":"36383","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2010.08.006"},{"key":"36384","doi-asserted-by":"publisher","DOI":"10.1586\/14779072.5.4.743"},{"key":"36385","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.105924"},{"key":"36386","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199007263230404"},{"key":"36387","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14423"},{"key":"36388","doi-asserted-by":"publisher","DOI":"10.7326\/M14-1589"},{"key":"36389","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000005355"},{"key":"36390","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14217"},{"key":"36391","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.212845"},{"key":"36392","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-304725"},{"key":"36393","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.223966"},{"key":"36394","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25500"},{"key":"36395","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018020370"},{"key":"36396","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17174"},{"key":"36397","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020007594"},{"key":"36398","doi-asserted-by":"publisher","DOI":"10.1016\/j.hemonc.2021.05.004"},{"key":"36399","doi-asserted-by":"publisher","DOI":"10.1213\/XAA.0000000000000621"},{"key":"36400","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-01-761262"},{"key":"36401","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2018.1492710"},{"key":"36402","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-9-100"},{"key":"36403","unstructured":"Mu\u00f1oz M, Stensballe J, Ducloy-Bouthors AS. Patient blood management in obstetrics: prevention and treatment of postpartum haemorrhage - NATA consensus statement. Blood Transfus. 2019; 17(2):112-136."},{"key":"36404","unstructured":"Franchini M, Mengoli C, Marietta M.. Safety of intravenous tranexamic acid in patients undergoing major orthopaedic surgery: a meta-analysis of randomised controlled trials. Blood Transfus. 2018; 16(1):36-43."},{"key":"36405","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-04-497123"},{"key":"36406","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20446"},{"key":"36407","doi-asserted-by":"publisher","DOI":"10.1007\/s002770100310"},{"key":"36408","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e3280147fd8"},{"key":"36409","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.121475"},{"key":"36410","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V82.10.2961.2961"},{"key":"36411","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-09-239087"},{"key":"36412","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-076679"},{"key":"36413","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-09-602573"},{"key":"36414","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26692"},{"key":"36415","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201708168"},{"key":"36416","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-02-768036"},{"key":"36417","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2017.1356920"},{"key":"36418","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2022.103581"},{"key":"36419","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.582686"},{"key":"36420","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2021.10.009"},{"key":"36421","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1480"},{"key":"36422","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e32834114bc"},{"key":"36423","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021014687"},{"key":"36424","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019002939"},{"key":"36425","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018016501"},{"key":"36426","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2015.10.010"},{"key":"36427","doi-asserted-by":"publisher","DOI":"10.1097\/MCD.0000000000000200"},{"key":"36428","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-09-806489"},{"key":"36429","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.178723"},{"key":"36430","doi-asserted-by":"publisher","DOI":"10.1038\/82511"},{"key":"36431","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-138-1-200301070-00028"},{"key":"36432","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1612582"},{"key":"36433","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81152-7"},{"key":"36434","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2019.1663809"},{"key":"36435","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1742207"},{"key":"36436","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007280"},{"key":"36437","doi-asserted-by":"publisher","DOI":"10.1126\/science.1233151"},{"key":"36438","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01641-x"},{"key":"36439","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.3253"},{"key":"36440","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(19)30021-3"},{"key":"36441","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-04-777136"},{"key":"36442","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-02-735290"},{"key":"36443","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2015.10.008"},{"key":"36444","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.9.2856"},{"key":"36445","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.701738"},{"key":"36446","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-016-0382-y"},{"key":"36447","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22476"},{"key":"36448","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn277"},{"key":"36449","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.2997-19"},{"key":"36450","doi-asserted-by":"publisher","DOI":"10.14639\/0392-100X-702"},{"key":"36451","doi-asserted-by":"publisher","DOI":"10.1111\/os.12157"},{"key":"36452","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2021-145814"},{"key":"36453","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abb8975"}],"container-title":["Haematologica"],"original-title":[],"link":[{"URL":"https:\/\/haematologica.org\/article\/download\/haematol.2022.280856\/74475","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/haematologica.org\/article\/download\/haematol.2022.280856\/74521","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/haematologica.org\/article\/download\/10655\/74475","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T10:01:48Z","timestamp":1794045708000},"score":1,"resource":{"primary":{"URL":"https:\/\/haematologica.org\/article\/view\/haematol.2022.280856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,19]]},"references-count":91,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,6,1]]}},"URL":"https:\/\/doi.org\/10.3324\/haematol.2022.280856","relation":{},"ISSN":["1592-8721","0390-6078"],"issn-type":[{"value":"1592-8721","type":"electronic"},{"value":"0390-6078","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5,19]]}}}