{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T10:32:09Z","timestamp":1794047529410,"version":"4.8.0"},"reference-count":0,"publisher":"Ferrata Storti Foundation (Haematologica)","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["haematol"],"abstract":"<jats:p>Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL) is today a curable disease. In the real life, too many adult ALL patients are not adequately worked up at diagnosis and treated, and this occurs in particular in elderly\/old individuals. We hereby discuss, through representative case descriptions, how Ph+ ALL patients diagnosed in their seventh, eight and nineth decade of life through a timely, accurate and personalized tyrosine kinase inhibitor (TKI) administration, in the absence of systemic chemotherapy, can experience long-lived responses, minimal residual disease negativity, and a good quality of life. To an extent that stopping TKI administration can also be considered. This perspective article represents a proof of concept that nowadays even in elderly\/old Ph+ ALL the disease can be cured or kept under prolonged control if adequately managed.<\/jats:p>","DOI":"10.3324\/haematol.2025.300060","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T09:04:41Z","timestamp":1769072681000},"source":"Crossref","is-referenced-by-count":0,"title":["Optimal management of elderly\/old Ph+ acute lymphoblastic leukemia patients"],"prefix":"10.3324","author":[{"given":"Robin","family":"Fo\u00e0","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Chiaretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicetto","family":"Ferrara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Pizzolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1856","published-online":{"date-parts":[[2026,1,22]]},"container-title":["Haematologica"],"original-title":[],"link":[{"URL":"https:\/\/haematologica.org\/article\/download\/13112\/79393","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/haematologica.org\/article\/download\/13112\/79393","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T10:10:55Z","timestamp":1794046255000},"score":1,"resource":{"primary":{"URL":"https:\/\/haematologica.org\/article\/view\/13112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,22]]},"references-count":0,"URL":"https:\/\/doi.org\/10.3324\/haematol.2025.300060","relation":{},"ISSN":["1592-8721","0390-6078"],"issn-type":[{"value":"1592-8721","type":"electronic"},{"value":"0390-6078","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1,22]]}}}