{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:03:09Z","timestamp":1791226989359,"version":"4.1.0"},"reference-count":0,"publisher":"Nepal Health Research Council","issue":"1","license":[{"start":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T00:00:00Z","timestamp":1694131200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nepal Health Res Counc"],"abstract":"<jats:p>Background: Patients with acute coronary syndrome may lead to various metabolic and electrophysiological changes that induce both asymptomatic and symptomatic life-threatening arrhythmias, which increases morbidity and mortality. Methods: This observational retrospective study was conducted at Manmohan Cardiothoracic Vascular and Transplant Center, Institute of Medicine, Maharajgunj, Kathmandu, Nepal. Three hundred ninety-five patients with a diagnosis of acute coronary syndrome were enrolled in the study. Results: A total of 395 patients were included in the study with a mean age of patients 61.29\u00b1 13.5 years and with male predominance. A total number of 115 cases of arrhythmia were recorded among which the most common were atrioventricular block (10%), reperfusion arrhythmia (9.6%) followed by ventricular premature complex (8%), atrial fibrillation\/flutter (6%), and ventricular tachycardia\/fibrillation (5%). There was a significant difference in the incidence of arrhythmia in acute coronary syndrome group. STEMI (39.7%), NSTEMI 26(20.8%) and unstable angina11(14.8%) respectively (p=&lt;0.001). Reperfusion arrhythmia was present in 89.47% of STEMI and 10.4 % of NSTEMI\/ unstable angina and was statistically significant (p-value &lt;0.001). A total of three patients (0.7%) needed permanent pacemaker insertion in the acute coronary syndrome group. All of these patients were STEMI which was 1.5% of total STEMI, two in inferior wall STEMI (2.6%) and 1 in anterior wall STEMI (0.8%). The total in-hospital mortality was 20 (5.06%), 17(8.6%) among STEMI and 3(2.4%) among NSTEMI, and none in unstable angina (P =&lt;0.001). Pulmonary edema (12.9%) was the most common in-hospital outcome followed by cardiac arrest (7.6%).Conclusions: Arrhythmia in acute coronary syndrome is a common problem and may lead to structural and functional impairment of myocardial function. Keywords: Arrythmias; coronary artery disease; STEMI<\/jats:p>","DOI":"10.33314\/jnhrc.v21i1.4019","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T06:35:05Z","timestamp":1732602905000},"page":"8-14","source":"Crossref","is-referenced-by-count":4,"title":["Arrhythmias: Its Occurrence, Risk Factors, Therapy, and Prognosis in Acute Coronary Syndrome"],"prefix":"10.33314","volume":"21","author":[{"given":"Raja Ram","family":"Khanal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratna Mani","family":"Gajurel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangam","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandra Mani","family":"Poudel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemant","family":"Shrestha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surya","family":"Devkota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Thapa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18778","published-online":{"date-parts":[[2023,9,8]]},"container-title":["Journal of Nepal Health Research Council"],"original-title":[],"deposited":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T06:35:44Z","timestamp":1732602944000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnhrc.com.np\/index.php\/jnhrc\/article\/view\/4019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,8]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,9,10]]}},"URL":"https:\/\/doi.org\/10.33314\/jnhrc.v21i1.4019","relation":{},"ISSN":["1999-6217","1727-5482"],"issn-type":[{"value":"1999-6217","type":"electronic"},{"value":"1727-5482","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9,8]]}}}