{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:08:10Z","timestamp":1792001290100,"version":"4.4.0"},"reference-count":0,"publisher":"Australian Centre for Disease Control","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Commun Dis Intell (2018)"],"abstract":"<jats:p>From 1 January to 31 December 2013, 26 institutions around Australia participated in the Australian Enterococcal Sepsis Outcome Programme (AESOP). The aim of AESOP 2013 was to determine the proportion of enterococcal bacteraemia isolates in Australia that are antimicrobial resistant, and to characterise the molecular epidemiology of the\u00a0Enterococcus faecium\u00a0isolates. Of the 826 unique episodes of bacteraemia investigated, 94.6% were caused by either\u00a0E. faecalis\u00a0(56.1%) or\u00a0E. faecium\u00a0(38.5%). Ampicillin resistance was not detected in\u00a0E. faecalis\u00a0but was detected in over 90% of\u00a0E. faecium.\u00a0Vancomycin non-susceptibility was reported in 0.2% and 40.9% of\u00a0E. faecalis\u00a0and\u00a0E. faecium\u00a0respectively and was predominately due to the acquisition of the\u00a0vanB\u00a0operon. Overall, 41.6% of\u00a0E. faecium\u00a0harboured\u00a0vanA\u00a0or\u00a0vanB\u00a0genes. The percentage of\u00a0E. faecium\u00a0bacteraemia isolates resistant to vancomycin in Australia is significantly higher than that seen in most European countries.\u00a0E. faecium\u00a0isolates consisted of 81 pulsed-field gel electrophoresis pulsotypes of which 72.3% were classified into 14 major pulsotypes containing five or more isolates. Multilocus sequence typing grouped the 14 major pulsotypes into clonal cluster 17, a major hospital-adapted polyclonal\u00a0E. faecium\u00a0cluster. Of the 2 predominant sequence types, ST203 (80 isolates) was identified across Australia and ST555 (40 isolates) was isolated primarily in the western and central regions (Northern Territory, South Australia and Western Australia) respectively. In conclusion, the AESOP 2013 has shown enterococcal bacteraemias in Australia are frequently caused by polyclonal ampicillin-resistant high-level gentamicin resistant\u00a0vanB E. faecium,\u00a0which have\u00a0limited treatment options.\u00a0Commun Dis Intell\u00a02014;38(4):E320\u2013E326.<\/jats:p>","DOI":"10.33321\/cdi.2014.38.52","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T22:11:55Z","timestamp":1749593515000},"page":"320-326","source":"Crossref","is-referenced-by-count":9,"title":["Australian Enterococcal Sepsis Outcome Programme annual report, 2013"],"prefix":"10.33321","volume":"38","author":[{"given":"Geoffrey W","family":"Coombs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie C","family":"Pearson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise A","family":"Daley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam T","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James O","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Gottlieb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin P","family":"Howden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul DR","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine M","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy P","family":"Stinear","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D","family":"Turnidge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Australian Group on Antimicrobial Resistance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18788","published-online":{"date-parts":[[2014,12,1]]},"container-title":["Communicable Diseases Intelligence"],"original-title":[],"link":[{"URL":"https:\/\/ojs.cdi.cdc.gov.au\/index.php\/cdi\/article\/download\/1233\/1413","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ojs.cdi.cdc.gov.au\/index.php\/cdi\/article\/download\/1233\/1413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T22:11:56Z","timestamp":1749593516000},"score":1,"resource":{"primary":{"URL":"https:\/\/ojs.cdi.cdc.gov.au\/index.php\/cdi\/article\/view\/1233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,1]]},"references-count":0,"URL":"https:\/\/doi.org\/10.33321\/cdi.2014.38.52","relation":{},"ISSN":["2209-6051"],"issn-type":[{"value":"2209-6051","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,1]]}}}