{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:08:13Z","timestamp":1792001293746,"version":"4.4.0"},"reference-count":0,"publisher":"Australian Centre for Disease Control","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Commun Dis Intell (2018)"],"abstract":"<jats:p>From 1 January to 31 December 2014, 27\u00a0institutions around Australia participated in the Australian Enterococcal Sepsis Outcome Programme (AESOP). The aim of AESOP 2014 was to determine the proportion of enterococcal bacteraemia isolates in Australia that were antimicrobial resistant, and to characterise the molecular epidemiology of the\u00a0Enterococcus faecium\u00a0isolates. Of the 952 unique episodes of bacteraemia investigated, 94.4% were caused by either\u00a0E. faecalis\u00a0(54.9%) or\u00a0E. faecium\u00a0(39.9%). Ampicillin resistance was detected in 0.6% of\u00a0E.\u00a0faecalis\u00a0and in 89.4% of\u00a0E. faecium.\u00a0Vancomycin non-susceptibility was reported in 0.2% and 46.1% of\u00a0E. faecalis\u00a0and\u00a0E.\u00a0faecium\u00a0respectively. Overall 51.1% of\u00a0E. faecium\u00a0harboured\u00a0vanA\u00a0or\u00a0vanB\u00a0genes. For the\u00a0vanA\/B\u00a0positive\u00a0E. faecium\u00a0isolates, 81.5% harboured\u00a0vanB\u00a0genes and 18.5%\u00a0vanA\u00a0genes. The percentage of\u00a0E. faecium\u00a0bacteraemia isolates resistant to vancomycin in Australia is significantly higher than that seen in most European countries.\u00a0E. faecium\u00a0consisted of 113 pulsed-field gel electrophoresis pulsotypes of which 68.9% of isolates were classified into 14 major pulsotypes containing 5 or more isolates. Multilocus sequence typing grouped the 14 major pulsotypes into clonal cluster 17, a major hospital-adapted polyclonal\u00a0E. faecium\u00a0cluster. The geographical distribution of the 4 predominant sequence types (ST203, ST796, ST555 and ST17) varied with only ST203 identified across most regions of Australia. Overall 74.7% of isolates belonging to the four predominant STs harboured\u00a0vanA\u00a0or\u00a0vanB\u00a0genes. In conclusion, the AESOP 2014 has shown enterococcal bacteraemias in Australia are frequently caused by polyclonal ampicillin-resistant high-level gentamicin resistant\u00a0vanA\u00a0or\u00a0vanB E. faecium,\u00a0which have\u00a0limited treatment options.\u00a0Commun Dis Intell\u00a02016;40(2):E236\u2013E243.<\/jats:p>","DOI":"10.33321\/cdi.2016.40.19","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T21:42:44Z","timestamp":1749591764000},"page":"236-242","source":"Crossref","is-referenced-by-count":14,"title":["Australian Group on Antimicrobial Resistance Australian Enterococcal Sepsis Outcome Programme annual report, 2014"],"prefix":"10.33321","volume":"40","author":[{"given":"Geoffrey W","family":"Coombs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise A","family":"Daley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung Thin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie C","family":"Pearson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Owen","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul DR","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Despina","family":"Kotsanas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan M","family":"Bell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D","family":"Turnidge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Australian Group on Antimicrobial Resistance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18788","published-online":{"date-parts":[[2016,6,1]]},"container-title":["Communicable Diseases Intelligence"],"original-title":[],"link":[{"URL":"https:\/\/ojs.cdi.cdc.gov.au\/index.php\/cdi\/article\/download\/845\/1101","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ojs.cdi.cdc.gov.au\/index.php\/cdi\/article\/download\/845\/1101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T21:43:02Z","timestamp":1749591782000},"score":1,"resource":{"primary":{"URL":"https:\/\/ojs.cdi.cdc.gov.au\/index.php\/cdi\/article\/view\/845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,1]]},"references-count":0,"URL":"https:\/\/doi.org\/10.33321\/cdi.2016.40.19","relation":{},"ISSN":["2209-6051"],"issn-type":[{"value":"2209-6051","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,1]]}}}