{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T09:14:49Z","timestamp":1761902089317,"version":"build-2065373602"},"reference-count":34,"publisher":"Korean Society of Pediatric Nephrology","issue":"3","content-domain":{"domain":["chikd.org"],"crossmark-restriction":true},"short-container-title":["Child Kidney Dis"],"abstract":"<jats:p>Purpose: Sepsis is a leading cause of pediatric critical illness and a major contributor to acute kidney injury (AKI). Sepsis-associated AKI (SA-AKI) worsens outcomes, yet current diagnostic criteria based on serum creatinine and urine output lack sensitivity for early detection. This study evaluated the diagnostic performance of neutrophil gelatinase-associated lipocalin (NGAL), angiopoietin- 2, and syndecan-1 for early identification of SA-AKI in children with sepsis.Methods: A prospective nested case-control study was conducted in children aged 1\u201318 years with sepsis. Participants were classified into SA-AKI and non-SA-AKI groups using pediatric Risk, Injury, Failure, Loss, End-stage Renal Disease (pRIFLE) criteria based on estimated creatinine clearance index (eCCI). Blood and urine samples were collected at baseline, 12, 24, and 48 hours to measure NGAL, angiopoietin-2, and syndecan-1 levels by enzyme-linked immunosorbent assay. Diagnostic accuracy was assessed using receiver operating characteristic (ROC) analysis.Results: Of 23 children enrolled, eight (34.8%) developed SA-AKI. Baseline creatinine, eCCI, urinary NGAL, and mean corpuscular volume (MCV) differed significantly between groups, whereas angiopoietin-2 and syndecan-1 did not. ROC analysis showed that 24-hour eCCI (area under the curve [AUC]=1.000; sensitivity 100%; specificity 100%) and 12- to 24-hour urinary NGAL (AUC=0.900; sensitivity 87.5%; specificity 86.7%) were the strongest predictors. MCV had moderate accuracy (AUC=0.767). Urinary NGAL correlated negatively with eCCI (r=\u22120.67).Conclusions: Urinary NGAL measured within 12\u201324 hours is a reliable early biomarker for SA-AKI in pediatric sepsis, complementing eCCI and pRIFLE criteria to enhance early diagnosis and management.<\/jats:p>","DOI":"10.3339\/ckd.25.031","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T08:56:48Z","timestamp":1761901008000},"page":"112-124","update-policy":"https:\/\/doi.org\/10.3339\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative diagnostic value of NGAL and multibiomarker models in pediatric sepsis-associated acute kidney injury in Indonesia: a preliminary study"],"prefix":"10.3339","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6766-8852","authenticated-orcid":true,"given":"Fina 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