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The patient presented with prenatally detected kidney cysts and exhibited clinical and laboratory features consistent with salt-wasting, including markedly elevated 17-hydroxyprogesterone levels, requiring treatment with hydrocortisone, fludrocortisone, and sodium chloride. Genetic analysis revealed a de novo truncating variant in PKD1 and two variants in CYP21A2. Hypertension developed at 3 years and 7 months despite unchanged steroid replacement doses, requiring antihypertensive treatment, and resolved after mineralocorticoid dose reduction. This case highlights the competing therapeutic demands of concurrent salt-wasting CAH and VEO-ADPKD, underscoring the importance of early genetic evaluation and integrated multidisciplinary surveillance.<\/jats:p>","DOI":"10.3339\/ckd.26.022","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T02:28:03Z","timestamp":1782786483000},"page":"151-155","update-policy":"https:\/\/doi.org\/10.3339\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Very-early-onset autosomal dominant polycystic kidney disease coexisting with congenital adrenal hyperplasia in a newborn: a case report"],"prefix":"10.3339","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6867-2335","authenticated-orcid":true,"given":"Chang","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3238-5315","authenticated-orcid":true,"given":"Hwa Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4159-586X","authenticated-orcid":true,"given":"Young Hwa","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1911-0253","authenticated-orcid":true,"given":"Chang Won","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0203-7443","authenticated-orcid":true,"given":"Jaehyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8477-0157","authenticated-orcid":true,"given":"Ji Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1891","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0047-y"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000448695"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000497485"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000533465"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0155-2"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-020-02207-8"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-1904"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000536165"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfac236"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-008-1090-9"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1210\/js.2017-00145"}],"container-title":["Childhood Kidney Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/chikd.org\/upload\/ckd-26-022.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T04:19:46Z","timestamp":1782793186000},"score":1,"resource":{"primary":{"URL":"http:\/\/chikd.org\/journal\/view.php?id=10.3339\/ckd.26.022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,30]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,6,28]]}},"URL":"https:\/\/doi.org\/10.3339\/ckd.26.022","relation":{},"ISSN":["2384-0242","2384-0250"],"issn-type":[{"value":"2384-0242","type":"print"},{"value":"2384-0250","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,30]]},"assertion":[{"value":"2026-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}